Medication interaction hub

What Supplements Interact with Esterified Estrogens?

Esterified Estrogens brand names: Menest, Estratab. Every interaction below applies to the brands too.

182 Interactions 3 Major 144 Moderate 35 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Esterified Estrogens? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Esterified Estrogens against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you take esterified estrogens (Menest, Estratab) for menopause symptoms, this page deserves a careful, unhurried read, and the three major-rated entries come first. Grapefruit slows how your body clears the hormone, raising its level and side effects, while St. John's wort speeds clearance and can quietly undercut your therapy. Activated charcoal is the third, since it can soak up the medicine before your body absorbs it. Most of the 144 moderate entries fall into two camps: herbs with estrogen-like activity of their own that can compete with your treatment, and ingredients that share the liver pathway processing the hormone.

Fiber-heavy products can also blunt absorption, so space them well apart from your dose. Only 35 of the 182 entries rate minor, so most of this page carries real weight. One everyday surprise sits in the moderate group: estrogen slows caffeine breakdown, so coffee, tea, and caffeine-containing herbs may hit you harder than usual.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 144 Minor 35 No known interaction 1,270

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Esterified Estrogens: Top Interactions at a Glance

The Esterified Estrogens supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 182 interacting ingredients — plus 1,270 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Esterified Estrogens Combinations Today

The Esterified Estrogens + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Hemp + Esterified Estrogensi

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Read the full interaction Moderate Likelihood Possible Dhea + Esterified Estrogensi

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Probable Red Clover + Esterified Estrogensi

Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.

Read the full interaction Moderate Likelihood Probable Vitex Agnus-castus + Esterified Estrogensi

Theoretically, vitex agnus-castus could interfere with the activity of estrogens.

Read the full interaction Moderate Likelihood Possible Moringa + Esterified Estrogensi

Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.

Read the full interaction Minor Likelihood Unlikely Deer Velvet + Esterified Estrogensi

Theoretically, deer velvet might increase the effects and side effects of estrogens.

Read the full interaction
The complete list

Every Supplement Checked Against Esterified Estrogens

All 1,452 ingredients in our database, ranked by severity — 182 with a Esterified Estrogens interaction on file and 1,270 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Esterified Estrogens?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Hemp with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Full Hemp + Esterified Estrogens answer

Can you take Dhea with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Esterified Estrogens answer

Can you take Red Clover with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.

Full Red Clover + Esterified Estrogens answer

Can you take Vitex Agnus-castus with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitex agnus-castus could interfere with the activity of estrogens.

Full Vitex Agnus-castus + Esterified Estrogens answer

Can you take Moringa with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.

Full Moringa + Esterified Estrogens answer

Can you take Danshen with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.

Full Danshen + Esterified Estrogens answer

Can you take Devil's Claw with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Esterified Estrogens answer

Can you take Diindolylmethane with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diindolylmethane might increase or decrease the effects of estrogens.

Full Diindolylmethane + Esterified Estrogens answer

Can you take Diosmin with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.

Full Diosmin + Esterified Estrogens answer

Can you take Dong Quai with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, dong quai may reduce the effects of estrogens.

Full Dong Quai + Esterified Estrogens answer

Can you take Echinacea with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.

Full Echinacea + Esterified Estrogens answer

Can you take Equol with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, equol might increase the levels and clinical effects of estrogens.

Full Equol + Esterified Estrogens answer

Can you take Eucalyptus with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Full Eucalyptus + Esterified Estrogens answer

Can you take European Barberry with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.

Full European Barberry + Esterified Estrogens answer

Can you take Evodia with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.

Full Evodia + Esterified Estrogens answer

Can you take False Unicorn with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full False Unicorn + Esterified Estrogens answer

Can you take Fennel with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Full Fennel + Esterified Estrogens answer

Can you take Feverfew with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.

Full Feverfew + Esterified Estrogens answer

Can you take Flaxseed with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking flaxseed might decrease the effects of estrogens.

Full Flaxseed + Esterified Estrogens answer

Can you take Garlic with Esterified Estrogens?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.

Full Garlic + Esterified Estrogens answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Esterified Estrogens is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Esterified Estrogens, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Esterified Estrogens sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Esterified Estrogens through this category.

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Esterified Estrogens through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Esterified Estrogens through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Esterified Estrogens through this category.

About Esterified Estrogens

Estrogen is a hormone used to treat hot flashes and vaginal symptoms during menopause, and to prevent bone loss in menopausal women.

Generic name: Esterified Estrogens  ·  Brand names: Menest, Estratab.

See the full Estrogen drug information

Related: does Esterified Estrogens deplete any nutrients?

Esterified Estrogens has 10 reported nutrient associations in the research literature — see the Esterified Estrogens nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Esterified Estrogens

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Esterified Estrogens.

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Pharmacist Counseling Corner

Esterified Estrogens & Supplements: Common Questions

What supplements interact with Esterified Estrogens?
More than you might expect — 182 in total, though they are far from equal: 3 are rated major, 144 moderate, and 35 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Esterified Estrogens supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Esterified Estrogens?
Usually yes — most people on Esterified Estrogens can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Menest have the same supplement interactions as Esterified Estrogens?
Yes — Menest, Estratab all contain Esterified Estrogens, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Esterified Estrogens deplete any vitamins or nutrients?
It might — Esterified Estrogens has 10 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Esterified Estrogens nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Esterified Estrogens and my other medications?
This page covers Esterified Estrogens against supplements and herbal ingredients. Checking Esterified Estrogens against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Estrogen drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.