Drug & supplement interaction

Maral Root + Progesterone (prescription drug)

Progesterone (prescription drug) brand names: Prometrium, Endometrin, Utrogestan.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Maral Root and Progesterone (prescription drug) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Maral Root and Progesterone (prescription drug)

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Progesterone (prescription drug) and Maral Root in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Maral Root safety at a glance

Maral Root overall Use caution Limited human safety data, so use carefully and under professional guidance.
Pregnancy Avoid Not enough safety information; avoid during pregnancy.
Breastfeeding Avoid Not enough safety information; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Progesterone (prescription drug) and Maral Root? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Progesterone (prescription drug)

Interactions in our licensed database are recorded against drug classes, not just single drug names. Progesterone (prescription drug) is filed under 6 classifications — including progestin, cytochrome p450 2c19 (cyp2c19) substrates, topical drugs. Maral Root has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Progesterone (prescription drug)’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Maral Root Does Interact With Other Medications

Maral Root has 122 moderate known drug interactions in our database — Progesterone (prescription drug) isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Progesterone (prescription drug))
Taking anything else?

Check Another of Your Medications Against Maral Root

Covers the 2,830 medications we’ve checked against Maral Root. Pick one to open its full report.

What to actually watch for

What Progesterone (prescription drug)’s Own FDA Label Lists

This is not an interaction — none of it involves Maral Root. These are the most notable effects listed in the ADVERSE REACTIONS section of Progesterone (prescription drug)’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Low mood Worth acting on
  • A higher chance of infection Worth acting on
  • Changes to your period
  • A change in sex drive
  • Passing urine more often
  • Breast tenderness
  • Mood changes or irritability
  • Bloating or gas
  • Back pain
  • Drowsiness

Showing the 10 most notable of 23 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Progesterone (prescription drug). Read the label on DailyMed › Maral Root’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Maral Root side to compare — that is a limit of the record, not a statement that Maral Root has no side effects.

Everything else you take

See Every Supplement That Interacts With Progesterone (prescription drug)

This page covers Maral Root only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Progesterone (prescription drug) page lists 148 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 104 moderate · 41 minor.

From our pharmacist’s overview on the Progesterone (prescription drug) page

“Prescription progesterone (Prometrium, Endometrin) supports pregnancy, regulates cycles, and protects the uterine lining during estrogen therapy, and because a steady hormone level is the whole point of taking it, its 148 documented supplement interactions warrant genuine vigilance. Most of them act on CYP3A4, the liver enzyme that cle…”

Reviewed by 2 · Jul 18, 2026

Open the Progesterone (prescription drug) interaction page

One more smart check

Taking Maral Root as Part of a Dietary Supplement Product? Check It for Interactions

We hold 82 real supplement products containing Maral Root, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Maral Root. Even though Maral Root itself has no known interaction with Progesterone (prescription drug), another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Maral Root and Progesterone (prescription drug) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Maral Root
Top half

#586 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Progesterone (prescription drug)
Top 10%

#238 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Maral Root reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Maral Root and Progesterone (prescription drug) records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Maral Root

What is Maral Root?

  • Physical performance and stamina
  • Muscle building
  • Fatigue and recovery
  • Stress and adaptation
  • General energy and vitality

Maral Root (Rhaponticum carthamoides) is a Siberian herb used as an 'adaptogen' and is popular among athletes for stamina and muscle building, largely because it contains plant compounds called ecdysteroids. Human evidence is very limited, so its benefits remain mostly unproven. Talk with a pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have a health condition.

Rhaponticum carthamoides · Asteraceae · Root and rhizome · Capsules, tablets, powder, liquid extract/tincture, tea

An interaction check asks whether these two react with each other — it does not ask whether Maral Root is a good idea for someone in your situation. Here is what our Maral Root record says about it on its own.

Maral Root: dosing

There is no officially established standard dose for Maral Root. Products vary widely in their strength and how much active compound they contain.The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Maral Root monograph — the full record covers uses, side effects and every documented interaction.

Read the full Maral Root monograph & all interactions
Medication

About Progesterone Vaginal

What Is Progesterone Vaginal Used For?

Brand names: Prometrium, Endometrin, Utrogestan

Progesterone vaginal products are used as part of fertility treatment. Endometrin, a vaginal insert, is used in an Assisted Reproductive Technology (ART) program to support embryo implantation in infertile women under 35. It also helps maintain pregnancy after implantation, up to 10 weeks.

Crinone, a vaginal gel, is also used in ART for women who need progesterone supplementation or replacement. Crinone 4% (and Crinone 8% if needed) is also used for secondary amenorrhea, meaning periods have stopped in a woman who previously had them.

See full Progesterone Vaginal drug information
Keep checking

Other Drugs & Maral Root

Browse every other medication we’ve checked against Maral Root — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Maral Root page.

No interaction 2,707 drugs checked — show the list

We also checked Maral Root against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Maral Root list.

See the full Maral Root interactions page
See every supplement checked against Progesterone (prescription drug), ranked by severity
Evidence & sources

Maral Root References

The 2 references that drive our Maral Root monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Koleckar V, Brojerova E, Rehakova Z, et al. In vitro antiplatelet activity of flavonoids from Leuzea carthamoides. Drug Chem Toxicol 2008;31(1):27-35.
  2. Ryan ED, Gerstner GR, Mota JA, et al. The Acute Effects of a Multi-Ingredient Herbal Supplement on Performance Fatigability: A Double-Blind, Randomized, and Placebo-Controlled Trial. J Diet Suppl 2021;18(5):507-516. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Maral Root and Progesterone (prescription drug) Together: Common Questions

Is it safe to take Maral Root with Progesterone (prescription drug)?
We do not list a known interaction between Maral Root and Progesterone (prescription drug). That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Maral Root and Progesterone (prescription drug) combination checked?
Interactions in our licensed database are recorded against drug classes. Progesterone (prescription drug) is filed under 6 classifications, and Maral Root has documented interactions with 1 drug class — none of Progesterone (prescription drug)'s classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Maral Root interact with any other medications?
Yes. Maral Root has 122 documented drug interactions in our database — Progesterone (prescription drug) is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Progesterone (prescription drug) interact with any supplements?
Yes. Progesterone (prescription drug) has documented interactions with 148 supplements in our database — Maral Root is not one of them. The Progesterone (prescription drug) interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Maral Root monograph Uses, safety profile, and every drug interaction in one place Progesterone Vaginal drug information The full plain-English guide to this medication Progesterone (prescription drug) supplement interactions Every supplement checked against Progesterone (prescription drug), ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Progesterone (prescription drug) and Maral Root?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.