Drug & supplement interaction

African Wild Potato + Buproprion, Dextromethorphan

Buproprion, Dextromethorphan brand name: Auvelity.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Buproprion, Dextromethorphan falls into 2 drug categories that African Wild Potato can interact with; the most serious is rated moderate. In vitro evidence shows that African wild potato extract can inhibit cytochrome P450 3A4 (CYP3A4) enzyme activity by up to 86%.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

African Wild Potato and Buproprion, Dextromethorphan

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

African Wild Potato interacts with whole categories of medication. Buproprion, Dextromethorphan falls into 2 of those categories, so it can interact with African Wild Potato in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

1 of 2

Why this applies to Buproprion, Dextromethorphan

Buproprion, Dextromethorphan falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES — the group African Wild Potato interacts with.

In vitro evidence shows that African wild potato extract can inhibit cytochrome P450 3A4 (CYP3A4) enzyme activity by up to 86%. Theoretically, African wild potato might increase levels of drugs metabolized by CYP3A4. However, in human research, African wild potato does not seem to affect the pharmacokinetics of Efavirenz, a CYP3A4 substrate. Until more is known, use African wild potato cautiously or avoid in patients taking drugs metabolized by CYP3A4. Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and numerous others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Auvelity is a combination of bupropion and dextromethorphan. Here, the bupropion piece actually does most of the work behind the scenes: it blocks an enzyme called CYP2D6, which slows the breakdown of dextromethorphan so it can build up and stay active in your brain. The CYP3A4 concern with African Wild Potato is a bit different. In a lab dish, the plant slowed down CYP3A4 quite a bit, and that pathway plays a smaller role in clearing dextromethorphan.

In theory, adding this supplement could nudge dextromethorphan levels higher, which might mean more dizziness, drowsiness, nausea, or feeling off. But this is only test-tube evidence, and in one human study the plant didn't change how a similar drug was handled, so the real-world risk looks small. Still, please run it by your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15. PubMed
Moderate

CYTOCHROME P450 2B6 (CYP2B6) SUBSTRATES

2 of 2

Buproprion, Dextromethorphan also falls under CYTOCHROME P450 2B6 (CYP2B6) SUBSTRATES.

In vitro research shows that African wild potato extract inhibits cytochrome P450 2B6 (CYP2B6). However, this effect has yet to be reported in humans. Until more is known, use with caution. Theoretically, concomitant use of African wild potato with CYP2B6 substrates might increase the risk for adverse effects from these substrates. Some of these drugs include ketamine (Ketalar), phenobarbital, orphenadrine (Norflex), secobarbital (Seconal), and dexamethasone (Decadron).
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Auvelity combines bupropion and dextromethorphan. Here, bupropion is the piece that matters: your liver uses an enzyme called CYP2B6 to break it down. Lab (test-tube) studies suggest African Wild Potato may slow that enzyme. If that happened in real life, bupropion could build up a bit, which might mean more of its usual effects, like trouble sleeping, a dry mouth, jitteriness, headache, or a faster heartbeat. At higher levels bupropion can also lower the seizure threshold, so that's the concern worth keeping an eye on.

The good news: this is only seen in lab work so far, never confirmed in people, so I wouldn't panic. Still, because we just don't have human data, it's smart to check with your pharmacist or doctor before pairing the two.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fasinu PS, Gutmann H, Schiller H, Bouic PJ, Rosenkranz B. The potential of Hypoxis hemerocallidea for herb-drug interaction. Pharm Biol. 2013 Dec;51(12):1499-507.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

African Wild Potato Also Interacts With Other Medications

African Wild Potato has 1,004 moderate known drug interactions in our database — the Buproprion, Dextromethorphan one above is among them. If you take anything else, check it against the full list below.

Moderate 1,004 No known interaction 1,826 (incl. Buproprion, Dextromethorphan)
Taking anything else?

Check Another of Your Medications Against African Wild Potato

Covers the 2,830 medications we’ve checked against African Wild Potato. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Buproprion, Dextromethorphan

This page covers African Wild Potato only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Buproprion, Dextromethorphan page lists 178 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 1,3-dmaa (moderate).

By severity: 4 major · 134 moderate · 40 minor.

From our pharmacist’s overview on the Buproprion, Dextromethorphan page

“Auvelity pairs dextromethorphan with bupropion to treat depression, and its interaction list is one to approach carefully, with 178 supplements on file and four of them rated major. St.”

Reviewed by 2 · Jul 18, 2026

Open the Buproprion, Dextromethorphan interaction page

One more smart check

Taking African Wild Potato as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing African Wild Potato, each one broken down to its full ingredient list — and combination products often carry several ingredients besides African Wild Potato. Your product may carry other ingredients that interact with Buproprion, Dextromethorphan too, on top of African Wild Potato — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where African Wild Potato and Buproprion, Dextromethorphan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement African Wild Potato
Top half

#431 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Buproprion, Dextromethorphan
Steady interest

#1,979 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About African Wild Potato

What is African Wild Potato?

  • Immune support
  • Prostate and urinary symptoms
  • Inflammation
  • General tonic/wellness
  • Skin conditions

African Wild Potato (Hypoxis hemerocallidea) is a southern African plant traditionally used as a tonic and for immune, prostate, and inflammatory complaints. Human evidence for these uses is very limited, and safety—especially during pregnancy, breastfeeding, or with serious illness—is not well established. Talk to a pharmacist or doctor before using it.

Read the full African Wild Potato monograph & all interactions
Medication

About Dextromethorphan and Bupropion

What Is Dextromethorphan and Bupropion Used For?

Brand name: Auvelity

Auvelity (dextromethorphan/bupropion) is approved to treat major depressive disorder (MDD) in adults. It is also approved to treat agitation associated with dementia due to Alzheimer's disease in adults.

Auvelity is not intended as an as-needed treatment for Alzheimer's-related agitation — it is a scheduled, ongoing medication. It is not approved for use in children or adolescents.

See full Dextromethorphan and Bupropion drug information
Keep checking

Other Drugs & African Wild Potato

Browse every other medication we’ve checked against African Wild Potato — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1,004Moderate
0Minor
1,825No known interaction
1,004 Moderate 1,825 No interaction
Moderate

1,004 interactions

Showing 60 of 1,004 moderate interactions — see all 1,004 on the African Wild Potato page.

No interaction 1,825 drugs checked — show the list

We also checked African Wild Potato against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,825 medications checked with no known interaction — see the full African Wild Potato list.

See the full African Wild Potato interactions page
See every supplement checked against Buproprion, Dextromethorphan, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
African Wild Potato monograph › Uses, safety, and every drug interaction in one place Buproprion, Dextromethorphan supplement interactions › Every supplement checked against Buproprion, Dextromethorphan, ranked by severity Dextromethorphan and Bupropion drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking African Wild Potato and Buproprion, Dextromethorphan Together: Common Questions

Can you take African Wild Potato with Buproprion, Dextromethorphan?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for African Wild Potato and Buproprion, Dextromethorphan?
Buproprion, Dextromethorphan belongs to more than one drug category, and African Wild Potato interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the African Wild Potato and Buproprion, Dextromethorphan interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.