Medication interaction hub

What Supplements Interact with Buproprion, Dextromethorphan?

Buproprion, Dextromethorphan brand name: Auvelity. Every interaction below applies to the brands too.

178 Interactions 4 Major 134 Moderate 40 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Buproprion, Dextromethorphan? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Buproprion, Dextromethorphan against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Auvelity pairs dextromethorphan with bupropion to treat depression, and its interaction list is one to approach carefully, with 178 supplements on file and four of them rated major. St. John's wort and grapefruit each change how the liver clears drugs like these, activated charcoal can pull medicine out of the gut before it absorbs, and lithium raises the risk of serotonin syndrome, a dangerous buildup of serotonin. Most of the 134 moderate entries act on those same liver enzymes, nudging drug levels up or down.

Twenty ingredients, 5-HTP among them, add serotonin activity of their own, which matters with an antidepressant that already works on that system. A few more can lower the seizure threshold, a known concern with bupropion, and 40 minor entries round out the list. Read the four major entries first, then scan below for whatever you actually take.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 134 Minor 40 No known interaction 1,274

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Buproprion, Dextromethorphan: Top Interactions at a Glance

The Buproprion, Dextromethorphan supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 178 interacting ingredients — plus 1,274 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Buproprion, Dextromethorphan Combinations Today

The Buproprion, Dextromethorphan + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Likely Grapefruit + Buproprion, Dextromethorphani

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Unlikely Green Tea + Buproprion, Dextromethorphani

Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Minor Likelihood Possible Hops + Buproprion, Dextromethorphani

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.

Read the full interaction Moderate Likelihood Possible Acetyl-l-carnitine + Buproprion, Dextromethorphani

Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders, wh...

Read the full interaction Moderate Likelihood Possible Iboga + Buproprion, Dextromethorphani

Theoretically, taking iboga with serotonergic drugs might increase levels of serotonin, resulting in additive effects with serotonergic drugs.

Read the full interaction Moderate Likelihood Possible Corydalis Yanhusuo + Buproprion, Dextromethorphani

Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP2D6.

Read the full interaction
The complete list

Every Supplement Checked Against Buproprion, Dextromethorphan

All 1,452 ingredients in our database, ranked by severity — 178 with a Buproprion, Dextromethorphan interaction on file and 1,274 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Buproprion, Dextromethorphan?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Grapefruit with Buproprion, Dextromethorphan?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Buproprion, Dextromethorphan answer

Can you take Green Tea with Buproprion, Dextromethorphan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.

Full Green Tea + Buproprion, Dextromethorphan answer

Can you take Hops with Buproprion, Dextromethorphan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.

Full Hops + Buproprion, Dextromethorphan answer

Can you take Acetyl-l-carnitine with Buproprion, Dextromethorphan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstr...

Full Acetyl-l-carnitine + Buproprion, Dextromethorphan answer

Can you take Iboga with Buproprion, Dextromethorphan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking iboga with serotonergic drugs might increase levels of serotonin, resulting in additive effects with serotonergic drug...

Full Iboga + Buproprion, Dextromethorphan answer

Can you take Marshmallow with Buproprion, Dextromethorphan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Buproprion, Dextromethorphan answer

Can you take Passion Flower with Buproprion, Dextromethorphan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, passion flower might decrease the effects of CYP3A4 substrates.

Full Passion Flower + Buproprion, Dextromethorphan answer

Can you take Puravive with Buproprion, Dextromethorphan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains Panax ginseng.

Full Puravive + Buproprion, Dextromethorphan answer

Can you take Rhodiola with Buproprion, Dextromethorphan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.

Full Rhodiola + Buproprion, Dextromethorphan answer

Can you take Valerian with Buproprion, Dextromethorphan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.

Full Valerian + Buproprion, Dextromethorphan answer

Can you take Vitamin D with Buproprion, Dextromethorphan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Buproprion, Dextromethorphan answer

Can you take Xanthan Gum with Buproprion, Dextromethorphan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Buproprion, Dextromethorphan answer

Can you take Yerba Mate with Buproprion, Dextromethorphan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yerba mate might increase the levels and clinical effects of CYP3A4 substrates.

Full Yerba Mate + Buproprion, Dextromethorphan answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Buproprion, Dextromethorphan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, THC may increase the levels and clinical effects of CYP3A4 substrates.

Full Delta-9-tetrahydrocannabinol (thc) + Buproprion, Dextromethorphan answer

Can you take Eleuthero with Buproprion, Dextromethorphan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.

Full Eleuthero + Buproprion, Dextromethorphan answer

Can you take Gymnema with Buproprion, Dextromethorphan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.

Full Gymnema + Buproprion, Dextromethorphan answer

Can you take Humann Superbeets Heart Chews with Buproprion, Dextromethorphan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Full Humann Superbeets Heart Chews + Buproprion, Dextromethorphan answer

Can you take Jequirity with Buproprion, Dextromethorphan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Full Jequirity + Buproprion, Dextromethorphan answer

Can you take Kava with Buproprion, Dextromethorphan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if kava inhibits CYP1A2; research is conflicting.

Full Kava + Buproprion, Dextromethorphan answer

Can you take Mommy's Bliss Gripe Water with Buproprion, Dextromethorphan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed.

Full Mommy's Bliss Gripe Water + Buproprion, Dextromethorphan answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Buproprion, Dextromethorphan is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Buproprion, Dextromethorphan, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Buproprion, Dextromethorphan sits in 11 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Buproprion, Dextromethorphan through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Buproprion, Dextromethorphan through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Buproprion, Dextromethorphan through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Buproprion, Dextromethorphan through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Buproprion, Dextromethorphan through this category.

Dextromethorphan (Robitussin Dm, Others) 9 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

9 of the supplement ingredients on this page reach Buproprion, Dextromethorphan through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Buproprion, Dextromethorphan through this category.

Antidepressant Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Buproprion, Dextromethorphan through this category.

Bupropion (Wellbutrin) 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Buproprion, Dextromethorphan through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Buproprion, Dextromethorphan through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Buproprion, Dextromethorphan through this category.

About Buproprion, Dextromethorphan

Dextromethorphan and bupropion is a combination medicine used to treat major depressive disorder in adults and agitation associated with dementia due to Alzheimer's disease.

Generic name: Buproprion, Dextromethorphan  ·  Brand name: Auvelity.

See the full Dextromethorphan and Bupropion drug information

Related: does Buproprion, Dextromethorphan deplete any nutrients?

Buproprion, Dextromethorphan has 1 reported nutrient association in the research literature — see the Buproprion, Dextromethorphan nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Buproprion, Dextromethorphan

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Buproprion, Dextromethorphan.

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Pharmacist Counseling Corner

Buproprion, Dextromethorphan & Supplements: Common Questions

What supplements interact with Buproprion, Dextromethorphan?
More than you might expect — 178 in total, though they are far from equal: 4 are rated major, 134 moderate, and 40 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Activated Charcoal, Lithium.
Which Buproprion, Dextromethorphan supplement interactions are the most serious?
The 4 major-rated combinations — led by Grapefruit, Activated Charcoal, Lithium and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Buproprion, Dextromethorphan?
Usually yes — most people on Buproprion, Dextromethorphan can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Auvelity have the same supplement interactions as Buproprion, Dextromethorphan?
Yes — Auvelity all contain Buproprion, Dextromethorphan, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Buproprion, Dextromethorphan deplete any vitamins or nutrients?
It might — Buproprion, Dextromethorphan has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Buproprion, Dextromethorphan nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Buproprion, Dextromethorphan and my other medications?
This page covers Buproprion, Dextromethorphan against supplements and herbal ingredients. Checking Buproprion, Dextromethorphan against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Dextromethorphan and Bupropion drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.