Drug & supplement interaction

Acetyl-l-carnitine + Buproprion, Dextromethorphan

Buproprion, Dextromethorphan brand name: Auvelity.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Acetyl-l-carnitine has a moderate interaction with Buproprion, Dextromethorphan. Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders, when taken with serotonergic drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Acetyl-l-carnitine and Buproprion, Dextromethorphan

Here is the interaction we found between these two, with the evidence behind it.

Moderate

SEROTONERGIC DRUGS

Why this applies to Buproprion, Dextromethorphan

Buproprion, Dextromethorphan falls under SEROTONERGIC DRUGS — the group Acetyl-l-carnitine interacts with.

Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders, when taken with serotonergic drugs.
Animal research shows that acetyl-L-carnitine can increase levels of serotonin in the brain.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Auvelity combines bupropion and dextromethorphan, and the dextromethorphan part nudges serotonin activity in the brain. The thinking here is that acetyl-L-carnitine might gently raise brain serotonin too. Stack the two together and, in theory, you could push serotonin a little higher than intended.

I want to be honest about how soft this signal is. It comes from animal research only, not from people, so it is more of a caution than a proven problem. Still, if you ever notice symptoms like agitation, a racing heart, sweating, shakiness, or confusion, that could point to too much serotonin, and you should seek help. Before adding this supplement, just run it by your pharmacist or doctor so they can look at your full medication list.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Veronese N, Stubbs B, Solmi M, Ajnakina O, Carvalho AF, Maggi S. Acetyl-L-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis. Psychosom Med. 2018;80(2):154-9. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Acetyl-l-carnitine Also Interacts With Other Medications

Acetyl-l-carnitine has 202 moderate known drug interactions in our database — the Buproprion, Dextromethorphan one above is one of them. If you take anything else, check it against the full list below.

Moderate 202 No known interaction 2,628 (incl. Buproprion, Dextromethorphan)
Taking anything else?

Check Another of Your Medications Against Acetyl-l-carnitine

Covers the 2,830 medications we’ve checked against Acetyl-l-carnitine. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Buproprion, Dextromethorphan

This page covers Acetyl-l-carnitine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Buproprion, Dextromethorphan page lists 178 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 1,3-dmaa (moderate).

By severity: 4 major · 134 moderate · 40 minor.

From our pharmacist’s overview on the Buproprion, Dextromethorphan page

“Auvelity pairs dextromethorphan with bupropion to treat depression, and its interaction list is one to approach carefully, with 178 supplements on file and four of them rated major. St.”

Reviewed by 2 · Jul 18, 2026

Open the Buproprion, Dextromethorphan interaction page

One more smart check

Taking Acetyl-l-carnitine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 405 real supplement products containing Acetyl-l-carnitine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Acetyl-l-carnitine. Your product may carry other ingredients that interact with Buproprion, Dextromethorphan too, on top of Acetyl-l-carnitine — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Acetyl-l-carnitine and Buproprion, Dextromethorphan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Acetyl-l-carnitine
Top 10%

#96 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Buproprion, Dextromethorphan
Steady interest

#1,890 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Acetyl-l-carnitine

What is Acetyl-l-carnitine?

Acetyl-l-carnitine
  • Memory and cognitive support
  • Nerve pain (neuropathy)
  • Energy and fatigue
  • Age-related decline
  • Male fertility
  • Mood support

Acetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells. It is most studied for nerve pain and memory-related conditions, though the evidence is mixed and often limited. It is generally well tolerated for short-term use, but you should talk with your pharmacist or doctor before starting it.

Read the full Acetyl-l-carnitine monograph & all interactions
Medication

About Dextromethorphan and Bupropion

What Is Dextromethorphan and Bupropion Used For?

Brand name: Auvelity

Auvelity (dextromethorphan/bupropion) is approved to treat major depressive disorder (MDD) in adults. It is also approved to treat agitation associated with dementia due to Alzheimer's disease in adults.

For Alzheimer's-related agitation, Auvelity is not meant to be taken only when agitation flares up — it is a scheduled, ongoing treatment, not an as-needed medication.

See full Dextromethorphan and Bupropion drug information
Keep checking

Other Drugs & Acetyl-l-carnitine

Browse every other medication we’ve checked against Acetyl-l-carnitine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
202Moderate
0Minor
2,627No known interaction
202 Moderate 2,627 No interaction
Moderate

202 interactions

Showing 60 of 202 moderate interactions — see all 202 on the Acetyl-l-carnitine page.

No interaction 2,627 drugs checked — show the list

We also checked Acetyl-l-carnitine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,627 medications checked with no known interaction — see the full Acetyl-l-carnitine list.

See the full Acetyl-l-carnitine interactions page
See every supplement checked against Buproprion, Dextromethorphan, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Acetyl-l-carnitine monograph › Uses, safety, and every drug interaction in one place Buproprion, Dextromethorphan supplement interactions › Every supplement checked against Buproprion, Dextromethorphan, ranked by severity Dextromethorphan and Bupropion drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Acetyl-l-carnitine and Buproprion, Dextromethorphan Together: Common Questions

Can you take Acetyl-l-carnitine with Buproprion, Dextromethorphan?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Acetyl-l-carnitine and Buproprion, Dextromethorphan interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Buproprion, Dextromethorphan and Acetyl-l-carnitine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.