Drug & supplement interaction

Palmitoylethanolamide (pea) + Buproprion, Dextromethorphan

Buproprion, Dextromethorphan brand name: Auvelity.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Palmitoylethanolamide (pea) and Buproprion, Dextromethorphan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Palmitoylethanolamide (pea) and Buproprion, Dextromethorphan

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Buproprion, Dextromethorphan and Palmitoylethanolamide (pea) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Palmitoylethanolamide (pea) at all — not against Buproprion, Dextromethorphan, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Palmitoylethanolamide (pea) safety at a glance

Palmitoylethanolam... overall Use caution Generally well tolerated in studies, but long-term safety data are limited.
Pregnancy Avoid Not enough safety information, so avoid use during pregnancy.
Breastfeeding Avoid Not enough safety information, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Buproprion, Dextromethorphan and Palmitoylethanolamide (pea)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Palmitoylethanolamide (pea) and Buproprion, Dextromethorphan May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea Additional detail

    Palmitoylethanolamide (pea)

    “Orally, PEA has been rarely reported to cause mild and transient gastrointestinal symptoms, such as nausea.”

    Palmitoylethanolamide (pea) · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    3 sources cited
    1. 93325. Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
    2. 93327. Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
    3. 106266. Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed

    Buproprion, Dextromethorphan

    Listed in the ADVERSE REACTIONS section of the FDA label for Buproprion, Dextromethorphan. Read the label on DailyMed ›

Reported for Palmitoylethanolamide (pea) but not commonly for Buproprion, Dextromethorphan: itching and dry skin.

Effects for Buproprion, Dextromethorphan come from the ADVERSE REACTIONS section of its FDA label; effects for Palmitoylethanolamide (pea) come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Buproprion, Dextromethorphan Is Prescribed For, and What Palmitoylethanolamide (pea) Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Buproprion, Dextromethorphan is a prescription medicine with approved uses on its FDA label. Palmitoylethanolamide (pea) is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Buproprion, Dextromethorphan is prescribed for: Auvelity (dextromethorphan/bupropion) is approved to treat major depressive disorder (MDD) in adults. It is also approved to treat agitation associated with dementia due to Alzheimer's disease in adults. Auvelity is not intended as an as-needed treatment for Alzheimer's-related agitation — it is a scheduled, ongoing medication. It is not approved for use in children or adolescents.

Palmitoylethanolamide (pea) has been studied for:

  • Depression studied, not established Palmitoylethanolamide (pea) has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Palmitoylethanolamide (pea) for depression

    It is unclear if oral PEA is beneficial for depression when used in combination with citalopram.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Buproprion, Dextromethorphan on your own; if you are taking Palmitoylethanolamide (pea) for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Buproprion, Dextromethorphan

This page covers Palmitoylethanolamide (pea) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Buproprion, Dextromethorphan page lists 178 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 1,3-dmaa (moderate).

By severity: 4 major · 134 moderate · 40 minor.

From our pharmacist’s overview on the Buproprion, Dextromethorphan page

“Auvelity pairs dextromethorphan with bupropion to treat depression, and its interaction list is one to approach carefully, with 178 supplements on file and four of them rated major. St.”

Reviewed by 2 · Jul 18, 2026

Open the Buproprion, Dextromethorphan interaction page

One more smart check

Taking Palmitoylethanolamide (pea) as Part of a Dietary Supplement Product? Check It for Interactions

We hold 97 real supplement products containing Palmitoylethanolamide (pea), each one broken down to its full ingredient list — and combination products often carry several ingredients besides Palmitoylethanolamide (pea). Even though Palmitoylethanolamide (pea) itself has no known interaction with Buproprion, Dextromethorphan, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Palmitoylethanolamide (pea) and Buproprion, Dextromethorphan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Palmitoylethanolamide (pea)
Steady interest

#992 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Buproprion, Dextromethorphan
Top half

#717 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Palmitoylethanolamide (pea) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Palmitoylethanolamide (pea) and Buproprion, Dextromethorphan records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Palmitoylethanolamide (pea)

What is Palmitoylethanolamide (pea)?

  • Chronic pain
  • Nerve (neuropathic) pain
  • Inflammation
  • Low back and sciatica pain
  • General immune and recovery support

Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it may help certain types of chronic and nerve pain, but the overall evidence is still limited and more high-quality studies are needed. It appears generally well tolerated, but talk with your pharmacist or doctor before starting it.

Not a plant; a fatty acid compound made in the body and found in some foods · Capsules, tablets, sublingual tablets, powders, and 'micronized' or 'ultramicronized' formulations

An interaction check asks whether these two react with each other — it does not ask whether Palmitoylethanolamide (pea) is a good idea for someone in your situation. Here is what our Palmitoylethanolamide (pea) record says about it on its own.

Palmitoylethanolamide (pea): dosing

There is no official, standardized dose of PEA. Studies have used a range of amounts and different formulations, including micronized and ultramicronized versions, which can affect how the body absorbs it.Because of this, the best approach is to follow the directions on the product label and start with the lowest suggested amount.

From our Palmitoylethanolamide (pea) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Palmitoylethanolamide (pea) monograph & all interactions
Medication

About Dextromethorphan and Bupropion

What Is Dextromethorphan and Bupropion Used For?

Brand name: Auvelity

Auvelity (dextromethorphan/bupropion) is approved to treat major depressive disorder (MDD) in adults. It is also approved to treat agitation associated with dementia due to Alzheimer's disease in adults.

Auvelity is not intended as an as-needed treatment for Alzheimer's-related agitation — it is a scheduled, ongoing medication. It is not approved for use in children or adolescents.

See full Dextromethorphan and Bupropion drug information
Keep checking

Other Drugs & Palmitoylethanolamide (pea)

Browse every other medication we’ve checked against Palmitoylethanolamide (pea) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Palmitoylethanolamide (pea) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Palmitoylethanolamide (pea) list.

See the full Palmitoylethanolamide (pea) interactions page
See every supplement checked against Buproprion, Dextromethorphan, ranked by severity
Evidence & sources

Palmitoylethanolamide (pea) References

The 4 references that drive our Palmitoylethanolamide (pea) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
  2. Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
  3. Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed
  4. Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: A dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639-641. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Palmitoylethanolamide (pea) and Buproprion, Dextromethorphan Together: Common Questions

Is it safe to take Palmitoylethanolamide (pea) with Buproprion, Dextromethorphan?
We do not list a known interaction between Palmitoylethanolamide (pea) and Buproprion, Dextromethorphan. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Palmitoylethanolamide (pea) and Buproprion, Dextromethorphan have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Palmitoylethanolamide (pea) and Buproprion, Dextromethorphan used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Palmitoylethanolamide (pea) in each. That is a conversation for your prescriber, especially if Buproprion, Dextromethorphan is being adjusted to a target.
Does Buproprion, Dextromethorphan interact with any supplements?
Yes. Buproprion, Dextromethorphan has documented interactions with 178 supplements in our database — Palmitoylethanolamide (pea) is not one of them. The Buproprion, Dextromethorphan interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Palmitoylethanolamide (pea) monograph Uses, safety profile, and every drug interaction in one place Dextromethorphan and Bupropion drug information The full plain-English guide to this medication Buproprion, Dextromethorphan supplement interactions Every supplement checked against Buproprion, Dextromethorphan, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Buproprion, Dextromethorphan and Palmitoylethanolamide (pea)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.