Drug & supplement interaction

African Wild Potato + Letrozole, Ribociclib Succinate

Letrozole, Ribociclib Succinate brand name: Kisqali Femara Co-Pack.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

African Wild Potato has a moderate interaction with Letrozole, Ribociclib Succinate. In vitro evidence shows that African wild potato extract can inhibit cytochrome P450 3A4 (CYP3A4) enzyme activity by up to 86%.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

African Wild Potato and Letrozole, Ribociclib Succinate

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

Why this applies to Letrozole, Ribociclib Succinate

Letrozole, Ribociclib Succinate falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES — the group African Wild Potato interacts with.

In vitro evidence shows that African wild potato extract can inhibit cytochrome P450 3A4 (CYP3A4) enzyme activity by up to 86%. Theoretically, African wild potato might increase levels of drugs metabolized by CYP3A4. However, in human research, African wild potato does not seem to affect the pharmacokinetics of Efavirenz, a CYP3A4 substrate. Until more is known, use African wild potato cautiously or avoid in patients taking drugs metabolized by CYP3A4. Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and numerous others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Your Kisqali plus Femara combo includes ribociclib, which the body clears mainly through a liver enzyme called CYP3A4. In test-tube studies, African Wild Potato blocked that same enzyme quite strongly. The worry is that, if this carried over into people, ribociclib could build up in your system and lead to more side effects, such as nausea, fatigue, low blood counts, or changes in your heart's rhythm (a prolonged QT interval). Neither of these drugs is a prodrug, so this would mean stronger effects, not weaker ones.

Here's the honest part: this is only laboratory evidence, and in one real human study the plant didn't change levels of a similar drug. So it's a possible concern, not a proven one. Since ribociclib already needs careful monitoring, please check with your oncology team or pharmacist before adding this supplement.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

African Wild Potato Also Interacts With Other Medications

African Wild Potato has 1,006 moderate known drug interactions in our database — the Letrozole, Ribociclib Succinate one above is one of them. If you take anything else, check it against the full list below.

Moderate 1,006 No known interaction 1,824 (incl. Letrozole, Ribociclib Succinate)
Taking anything else?

Check Another of Your Medications Against African Wild Potato

Covers the 2,830 medications we’ve checked against African Wild Potato. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Letrozole, Ribociclib Succinate

This page covers African Wild Potato only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Letrozole, Ribociclib Succinate page lists 155 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 109 moderate · 38 minor.

From our pharmacist’s overview on the Letrozole, Ribociclib Succinate page

“Grapefruit tops my worry list for anyone taking the Kisqali Femara Co-Pack (letrozole and ribociclib), because it blocks the enzyme, CYP3A4, that clears ribociclib and can push levels of this breast cancer drug higher than intended. That enzyme thread runs through 121 of the 155 ingredients on this page, and with eight rated major, rea…”

Reviewed by 2 · Jul 18, 2026

Open the Letrozole, Ribociclib Succinate interaction page

One more smart check

Taking African Wild Potato as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing African Wild Potato, each one broken down to its full ingredient list — and combination products often carry several ingredients besides African Wild Potato. Your product may carry other ingredients that interact with Letrozole, Ribociclib Succinate too, on top of African Wild Potato — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where African Wild Potato and Letrozole, Ribociclib Succinate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement African Wild Potato
Top half

#652 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Letrozole, Ribociclib Succinate
Top half

#842 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About African Wild Potato

What is African Wild Potato?

  • Immune support
  • Prostate and urinary symptoms
  • Inflammation
  • General tonic/wellness
  • Skin conditions

African Wild Potato (Hypoxis hemerocallidea) is a southern African plant traditionally used as a tonic and for immune, prostate, and inflammatory complaints. Human evidence for these uses is very limited, and safety—especially during pregnancy, breastfeeding, or with serious illness—is not well established. Talk to a pharmacist or doctor before using it.

Read the full African Wild Potato monograph & all interactions
Keep checking

Other Drugs & African Wild Potato

Browse every other medication we’ve checked against African Wild Potato — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1,006Moderate
0Minor
1,823No known interaction
1,006 Moderate 1,823 No interaction
Moderate

1,006 interactions

Showing 60 of 1,006 moderate interactions — see all 1,006 on the African Wild Potato page.

No interaction 1,823 drugs checked — show the list

We also checked African Wild Potato against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,823 medications checked with no known interaction — see the full African Wild Potato list.

See the full African Wild Potato interactions page
See every supplement checked against Letrozole, Ribociclib Succinate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
African Wild Potato monograph › Uses, safety, and every drug interaction in one place Letrozole, Ribociclib Succinate supplement interactions › Every supplement checked against Letrozole, Ribociclib Succinate, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking African Wild Potato and Letrozole, Ribociclib Succinate Together: Common Questions

Can you take African Wild Potato with Letrozole, Ribociclib Succinate?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the African Wild Potato and Letrozole, Ribociclib Succinate interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Letrozole, Ribociclib Succinate and African Wild Potato?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.