Drug & supplement interaction

African Wild Potato + Goserelin

Goserelin brand name: Zoladex.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between African Wild Potato and Goserelin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

African Wild Potato and Goserelin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Goserelin and African Wild Potato in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

African Wild Potato safety at a glance

African Wild Potat... overall Use caution Limited human safety data and unclear effective doses mean it should be used cautiously.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Goserelin and African Wild Potato? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Goserelin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Goserelin is filed under a single classification — oral drugs. African Wild Potato has documented interactions with 9 drug classes — the most serious being antidiabetes drugs (moderate), cytochrome p450 1a2 (cyp1a2) substrates (moderate) and cytochrome p450 2b6 (cyp2b6) substrates (moderate) — and none of Goserelin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

African Wild Potato Does Interact With Other Medications

African Wild Potato has 1,005 moderate known drug interactions in our database — Goserelin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1,005 No known interaction 1,825 (incl. Goserelin)
Taking anything else?

Check Another of Your Medications Against African Wild Potato

Covers the 2,830 medications we’ve checked against African Wild Potato. Pick one to open its full report.

What to actually watch for

What African Wild Potato Itself Has Been Linked To

This is not an interaction — nothing below involves Goserelin. It is the side-effect record for African Wild Potato on its own, from the licensed Natural Medicines monograph. If something new turns up after you add African Wild Potato, this list is the first place to look.

  • A change in sex drive / Erection problems Additional detail

    “There is limited information available about the adverse effects of African wild potato. Some studies have evaluated constituents isolated from African wild potato, including beta-sitosterol and hypoxoside. Side effects reported with beta-sitosterol include nausea, indigestion, gas, diarrhea, constipation, erectile dysfunction, and loss of libido.”

    African Wild Potato · Natural Medicines adverse-effect record, reported in anxiety.

    4 sources cited
    1. 5327. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet 1995;345:1529-32.
    2. 5328. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. Br J Urol 1997;80:427-32.
    3. 5942. Berges RR, Windeler J, Trampisch HJ, et al. Randomized, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Lancet 1995;345:1529-32.
    4. 13584. Smit BJ, Albrecht CF, Liebenberg RW, et al A phase I trial of hypoxoside as an oral prodrug for cancer therapy--absence of toxicity. S Afr Med J 1995;85:865-70.

    “Orally, the beta-sitosterol constituent of African wild potato has been reported to cause erectile dysfunction and loss of libido.”

    African Wild Potato · Natural Medicines adverse-effect record, reported in erectile dysfunction (ed).

    1 source cited
    1. 5942. Berges RR, Windeler J, Trampisch HJ, et al. Randomized, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Lancet 1995;345:1529-32.
  • Anxiety or restlessness Additional detail

    “Orally, hypoxoside, an African wild potato constituent, has been reported to cause anxiety in one small, uncontrolled study.”

    African Wild Potato · Natural Medicines adverse-effect record, reported in anxiety.

    1 source cited
    1. 13584. Smit BJ, Albrecht CF, Liebenberg RW, et al A phase I trial of hypoxoside as an oral prodrug for cancer therapy--absence of toxicity. S Afr Med J 1995;85:865-70.
  • Stomach upset / Constipation / Diarrhea / Vomiting / Nausea Additional detail

    “Orally, specific beta-sitosterol extracts from African wild potato (Azuprostat, Harzol) can cause nausea, indigestion, gas, diarrhea, or constipation. Hypoxoside, an African wild potato constituent, has been reported to cause nausea, vomiting, and diarrhea in one small, uncontrolled study.”

    African Wild Potato · Natural Medicines adverse-effect record, reported in constipation.

    3 sources cited
    1. 5327. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet 1995;345:1529-32.
    2. 5328. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. Br J Urol 1997;80:427-32.
    3. 13584. Smit BJ, Albrecht CF, Liebenberg RW, et al A phase I trial of hypoxoside as an oral prodrug for cancer therapy--absence of toxicity. S Afr Med J 1995;85:865-70.

Everything above comes from the Natural Medicines adverse-effect record for African Wild Potato — expand a row for the licensed statement it rests on. We haven’t matched Goserelin to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Goserelin.

Everything else you take

See Every Supplement That Interacts With Goserelin

This page covers African Wild Potato only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Goserelin page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Goserelin page

“Goserelin (Zoladex) is given as a small implant under the skin, usually for prostate cancer, certain breast cancers, or endometriosis, and I would want anyone on it to read this list with real attention. All 17 flagged ingredients raise the same basic concern, changing how drugs are absorbed or retained, and the single major-rated one…”

Reviewed by 2 · Jul 18, 2026

Open the Goserelin interaction page

One more smart check

Taking African Wild Potato as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing African Wild Potato, each one broken down to its full ingredient list — and combination products often carry several ingredients besides African Wild Potato. Even though African Wild Potato itself has no known interaction with Goserelin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where African Wild Potato and Goserelin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement African Wild Potato
Top half

#412 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Goserelin
Steady interest

#1,786 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every African Wild Potato reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The African Wild Potato and Goserelin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About African Wild Potato

What is African Wild Potato?

  • Immune support
  • Prostate and urinary symptoms
  • Inflammation
  • General tonic/wellness
  • Skin conditions

African Wild Potato (Hypoxis hemerocallidea) is a southern African plant traditionally used as a tonic and for immune, prostate, and inflammatory complaints. Human evidence for these uses is very limited, and safety—especially during pregnancy, breastfeeding, or with serious illness—is not well established. Talk to a pharmacist or doctor before using it.

Hypoxis hemerocallidea · Hypoxidaceae · Corm (underground tuber/rootstock) · Capsules, tablets, tinctures, dried corm extracts, traditional decoctions

An interaction check asks whether these two react with each other — it does not ask whether African Wild Potato is a good idea for someone in your situation. Here is what our African Wild Potato record says about it on its own.

African Wild Potato: dosing

There is no well-established, standardized dose for African Wild Potato. Products vary widely in strength and in how they are prepared, so it is hard to compare one to another.If you choose to use it, follow the directions on the product label and do not exceed them. A pharmacist can help you review a specific product, check for quality concerns, and make sure it is appropriate for you. Choose products from reputable manufacturers, since supplement quality is not tightly regulated.

From our African Wild Potato monograph — the full record covers uses, side effects and every documented interaction.

Read the full African Wild Potato monograph & all interactions
Medication

About Goserelin Implant

What Is Goserelin Implant Used For?

Brand name: Zoladex

  • Goserelin implant is used in combination with radiation therapy and other medications to treat localized prostate cancer and is used alone to treat the symptoms associated with advanced prostate cancer. It is also used to treat advanced breast cancer in certain women. It is also used to manage endometriosis (a condition in which the type of tissue that lines the uterus [womb] grows in other areas of the body and causes pain, heavy or irregular menstruation [periods], and other symptoms) and to help with the treatment of abnormal bleeding of the uterus. Goserelin implant is in a class of medications called gonadotropin-releasing hormone (GnRH) agonists. It works by decreasing the amount of certain hormones in the body.

Most-Reported Side Effects for Goserelin

From FAERS, the FDA’s public side-effect reporting system (13,351 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Malignant neoplasm progression 1,340 reports
Fatigue 886 reports
Metastases to bone 698 reports
Neutropenia 656 reports
Nausea 600 reports
See full Goserelin Implant drug information
Keep checking

Other Drugs & African Wild Potato

Browse every other medication we’ve checked against African Wild Potato — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1,005Moderate
0Minor
1,824No known interaction
1,005 Moderate 1,824 No interaction
Moderate

1,005 interactions

Showing 60 of 1,005 moderate interactions — see all 1,005 on the African Wild Potato page.

No interaction 1,824 drugs checked — show the list

We also checked African Wild Potato against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,824 medications checked with no known interaction — see the full African Wild Potato list.

See the full African Wild Potato interactions page
See every supplement checked against Goserelin, ranked by severity
Evidence & sources

African Wild Potato References

The 10 references that drive our African Wild Potato monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet 1995;345:1529-32.
  2. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. Br J Urol 1997;80:427-32.
  3. Berges RR, Windeler J, Trampisch HJ, et al. Randomized, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Lancet 1995;345:1529-32.
  4. Berges RR, Kassen A, Senge T. Treatment of symptomatic benign prostatic hyperplasia with beta-sitosterol: an 18-month follow-up. BJU Int 2000;85:842-6.
  5. Mahomed IM, Ojewole JA. Hypoglycemic effect of Hypoxis hemerocallidea corm (African potato) aqueous extract in rats. Methods Find Exp Clin Pharmacol 2003;25:617-23. PubMed
  6. Smit BJ, Albrecht CF, Liebenberg RW, et al A phase I trial of hypoxoside as an oral prodrug for cancer therapy--absence of toxicity. S Afr Med J 1995;85:865-70.
  7. Wilt TJ, Ishani A, Rutks I, et al. Phytotherapy for benign prostatic hyperplasia. Public Health Nutr 2000;3(4A):459-472. PubMed
  8. Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15. PubMed
  9. Fasinu PS, Gutmann H, Schiller H, Bouic PJ, Rosenkranz B. The potential of Hypoxis hemerocallidea for herb-drug interaction. Pharm Biol. 2013 Dec;51(12):1499-507.
  10. Havenga K, Abay E, Wiesner L, Viljoen A, Steyn D, Hamman J. The in vitro and in vivo effects of Hypoxis hemerocallidea on indinavir pharmacokinetics: modulation of efflux. Planta Med. 2018;84(12-13):895-901. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking African Wild Potato and Goserelin Together: Common Questions

Is it safe to take African Wild Potato with Goserelin?
We do not list a known interaction between African Wild Potato and Goserelin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the African Wild Potato and Goserelin combination checked?
Interactions in our licensed database are recorded against drug classes. Goserelin is filed under 1 classification, and African Wild Potato has documented interactions with 9 drug classes — none of Goserelin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does African Wild Potato interact with any other medications?
Yes. African Wild Potato has 1,005 documented drug interactions in our database — Goserelin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Goserelin interact with any supplements?
Yes. Goserelin has documented interactions with 17 supplements in our database — African Wild Potato is not one of them. The Goserelin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

African Wild Potato monograph Uses, safety profile, and every drug interaction in one place Goserelin Implant drug information The full plain-English guide to this medication Goserelin supplement interactions Every supplement checked against Goserelin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Goserelin and African Wild Potato?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.