Drug & supplement interaction

African Wild Potato + Bempedoic Acid, Ezetimibe

Bempedoic Acid, Ezetimibe brand name: Nexlizet.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

African Wild Potato has a moderate interaction with Bempedoic Acid, Ezetimibe. In vitro evidence shows that African wild potato extract inhibits OAT3.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

African Wild Potato and Bempedoic Acid, Ezetimibe

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES

Why this applies to Bempedoic Acid, Ezetimibe

Bempedoic Acid, Ezetimibe falls under ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES — the group African Wild Potato interacts with.

In vitro evidence shows that African wild potato extract inhibits OAT3. This drug transport protein is involved in renal tubular uptake of some drugs from the blood and then elimination in the urine. Inhibition of this transporter decreases renal elimination and increases drug levels in the body. The clinical significance of this in humans is not known.
Some substrates of OAT3 include cephalosporins, famotidine (Pepcid), furosemide (Lasix), hydrochlorothiazide (HCTZ), methotrexate, NSAIDs, probenecid, ranitidine (Zantac).
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for Nexlizet, which combines bempedoic acid and ezetimibe to help lower cholesterol. Your kidneys use a little doorway protein called OAT3 to help clear certain medicines out through your urine. In test-tube studies, African Wild Potato appears to block that doorway. In theory, if that same thing happens in people, bempedoic acid could leave your body a bit slower and build up somewhat higher than usual.

What I want you to know is that this is very early evidence, from lab work only, not from actual patients. So I'm not ringing alarm bells. If levels did creep up, the things to watch for with bempedoic acid are muscle aches or, less commonly, gout flares or joint pain. Before you pair these two, just run it by your pharmacist or doctor so they can keep an eye on things.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fasinu PS, Gutmann H, Schiller H, Bouic PJ, Rosenkranz B. The potential of Hypoxis hemerocallidea for herb-drug interaction. Pharm Biol. 2013 Dec;51(12):1499-507.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

African Wild Potato Also Interacts With Other Medications

African Wild Potato has 1,006 moderate known drug interactions in our database — the Bempedoic Acid, Ezetimibe one above is one of them. If you take anything else, check it against the full list below.

Moderate 1,006 No known interaction 1,824 (incl. Bempedoic Acid, Ezetimibe)
Taking anything else?

Check Another of Your Medications Against African Wild Potato

Covers the 2,830 medications we’ve checked against African Wild Potato. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Bempedoic Acid, Ezetimibe

This page covers African Wild Potato only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bempedoic Acid, Ezetimibe page lists 21 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Banderol (moderate), Caffeic Acid (moderate), Coffee Charcoal (moderate) and European Mandrake (moderate).

By severity: 1 major · 11 moderate · 9 minor.

From our pharmacist’s overview on the Bempedoic Acid, Ezetimibe page

“Nexlizet pairs bempedoic acid with ezetimibe to lower LDL cholesterol, and since the pill only works if it gets absorbed and holds a steady level, the 21 supplements below deserve careful handling. The single major-rated entry, activated charcoal, can bind the drug in the gut and cut how much reaches the blood, so I would rule that one…”

Reviewed by 2 · Jul 18, 2026

Open the Bempedoic Acid, Ezetimibe interaction page

One more smart check

Taking African Wild Potato as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing African Wild Potato, each one broken down to its full ingredient list — and combination products often carry several ingredients besides African Wild Potato. Your product may carry other ingredients that interact with Bempedoic Acid, Ezetimibe too, on top of African Wild Potato — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where African Wild Potato and Bempedoic Acid, Ezetimibe Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement African Wild Potato
Top half

#651 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bempedoic Acid, Ezetimibe
Steady interest

#1,935 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About African Wild Potato

What is African Wild Potato?

  • Immune support
  • Prostate and urinary symptoms
  • Inflammation
  • General tonic/wellness
  • Skin conditions

African Wild Potato (Hypoxis hemerocallidea) is a southern African plant traditionally used as a tonic and for immune, prostate, and inflammatory complaints. Human evidence for these uses is very limited, and safety—especially during pregnancy, breastfeeding, or with serious illness—is not well established. Talk to a pharmacist or doctor before using it.

Read the full African Wild Potato monograph & all interactions
Keep checking

Other Drugs & African Wild Potato

Browse every other medication we’ve checked against African Wild Potato — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1,006Moderate
0Minor
1,823No known interaction
1,006 Moderate 1,823 No interaction
Moderate

1,006 interactions

Showing 60 of 1,006 moderate interactions — see all 1,006 on the African Wild Potato page.

No interaction 1,823 drugs checked — show the list

We also checked African Wild Potato against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,823 medications checked with no known interaction — see the full African Wild Potato list.

See the full African Wild Potato interactions page
See every supplement checked against Bempedoic Acid, Ezetimibe, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
African Wild Potato monograph › Uses, safety, and every drug interaction in one place Bempedoic Acid, Ezetimibe supplement interactions › Every supplement checked against Bempedoic Acid, Ezetimibe, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking African Wild Potato and Bempedoic Acid, Ezetimibe Together: Common Questions

Can you take African Wild Potato with Bempedoic Acid, Ezetimibe?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the African Wild Potato and Bempedoic Acid, Ezetimibe interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Bempedoic Acid, Ezetimibe and African Wild Potato?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.