Drug & supplement interaction

Banderol + Bempedoic Acid, Ezetimibe

Bempedoic Acid, Ezetimibe brand name: Nexlizet.

Moderate Interaction
Medically reviewed by · Updated February 2023
The bottom line Moderate

Banderol has a moderate interaction with Bempedoic Acid, Ezetimibe. Small lab studies have found that Banderol may also inhibit OATP1B3 (Organic Anion Transporting Polypeptide 1B3), in addition to OATP1B1.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceA
What do Severity, Likelihood & Evidence mean?
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Interaction report

Banderol and Bempedoic Acid, Ezetimibe

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES

Why this applies to Bempedoic Acid, Ezetimibe

Bempedoic Acid, Ezetimibe falls under ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES — the group Banderol interacts with.

Small lab studies have found that Banderol may also inhibit OATP1B3 (Organic Anion Transporting Polypeptide 1B3), in addition to OATP1B1. If a drug is a substrate for both transporters, the risk of interaction with Banderol increases but the overall clinical significance is not well understood.
Severity Moderate Likelihood Possible Evidence A

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here is the short version for Nexlizet, which combines bempedoic acid and ezetimibe to help lower cholesterol. Banderol has shown, in small test-tube studies only, that it may block certain liver uptake transporters (OATP1B1 and OATP1B3). If a drug relies on those transporters, blocking them could let a little more of the drug linger in your bloodstream.

In practical terms, that might nudge Nexlizet levels up slightly, which could mean a bit more chance of side effects like muscle aches, joint pain, or stomach upset. Honestly though, this is theoretical lab data, and the real-world impact isn't well understood. Neither drug is a prodrug here, so we're not worried about lost benefit. Please loop in your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Banderol Also Interacts With Other Medications

Banderol has 176 moderate known drug interactions in our database — the Bempedoic Acid, Ezetimibe one above is one of them. If you take anything else, check it against the full list below.

Moderate 176 No known interaction 2,654 (incl. Bempedoic Acid, Ezetimibe)
Taking anything else?

Check Another of Your Medications Against Banderol

Covers the 2,830 medications we’ve checked against Banderol. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Bempedoic Acid, Ezetimibe

This page covers Banderol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bempedoic Acid, Ezetimibe page lists 21 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), African Wild Potato (moderate), Caffeic Acid (moderate), Coffee Charcoal (moderate) and European Mandrake (moderate).

By severity: 1 major · 11 moderate · 9 minor.

From our pharmacist’s overview on the Bempedoic Acid, Ezetimibe page

“Nexlizet pairs bempedoic acid with ezetimibe to lower LDL cholesterol, and since the pill only works if it gets absorbed and holds a steady level, the 21 supplements below deserve careful handling. The single major-rated entry, activated charcoal, can bind the drug in the gut and cut how much reaches the blood, so I would rule that one…”

Reviewed by 2 · Jul 18, 2026

Open the Bempedoic Acid, Ezetimibe interaction page

How much people look this up

Where Banderol and Bempedoic Acid, Ezetimibe Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Banderol
Steady interest

#1,049 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bempedoic Acid, Ezetimibe
Top half

#875 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Banderol

What is Banderol?

Banderol
  • Lyme disease support
  • Antimicrobial
  • Antifungal
  • Immune support
  • Inflammation

Banderol is a Nutramedix-branded herbal extract made from the bark of the Amazonian tree Otoba parvifolia, most often promoted as part of alternative Lyme disease protocols. There is very little high-quality human research to support its use, so the evidence behind its benefits is weak and largely preliminary. Talk with your pharmacist or doctor before using it, and never use it to replace proven treatments.

Read the full Banderol monograph & all interactions
Keep checking

Other Drugs & Banderol

Browse every other medication we’ve checked against Banderol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
176Moderate
0Minor
2,653No known interaction
176 Moderate 2,653 No interaction
Moderate

176 interactions

Showing 60 of 176 moderate interactions — see all 176 on the Banderol page.

No interaction 2,653 drugs checked — show the list

We also checked Banderol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,653 medications checked with no known interaction — see the full Banderol list.

See the full Banderol interactions page
See every supplement checked against Bempedoic Acid, Ezetimibe, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Banderol monograph › Uses, safety, and every drug interaction in one place Bempedoic Acid, Ezetimibe supplement interactions › Every supplement checked against Bempedoic Acid, Ezetimibe, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Banderol and Bempedoic Acid, Ezetimibe Together: Common Questions

Can you take Banderol with Bempedoic Acid, Ezetimibe?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Banderol and Bempedoic Acid, Ezetimibe interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.