Drug & supplement interaction

African Wild Potato + Nepafenac

Nepafenac brand names: Nevanac, Ilevro.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Nepafenac falls into 2 drug categories that African Wild Potato can interact with; the most serious is rated moderate. In vitro evidence shows that African wild potato extract inhibits OAT3.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

African Wild Potato and Nepafenac

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

African Wild Potato interacts with whole categories of medication. Nepafenac falls into 2 of those categories, so it can interact with African Wild Potato in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES

1 of 2

Why this applies to Nepafenac

Nepafenac falls under ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES — the group African Wild Potato interacts with.

In vitro evidence shows that African wild potato extract inhibits OAT3. This drug transport protein is involved in renal tubular uptake of some drugs from the blood and then elimination in the urine. Inhibition of this transporter decreases renal elimination and increases drug levels in the body. The clinical significance of this in humans is not known.
Some substrates of OAT3 include cephalosporins, famotidine (Pepcid), furosemide (Lasix), hydrochlorothiazide (HCTZ), methotrexate, NSAIDs, probenecid, ranitidine (Zantac).
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the good news about this pairing: nepafenac is an eye drop you use after cataract surgery, not a pill. The concern on file is that African Wild Potato may block a kidney transporter called OAT3, which could let certain NSAIDs build up in the body. But with eye drops, very little medicine actually reaches your bloodstream, so a kidney-clearance interaction is unlikely to matter much here.

On top of that, this warning comes only from lab (test tube) studies, not from people, so we honestly don't know how meaningful it is in real life. I wouldn't lose sleep over it, but since safety data on this supplement is thin, it's still worth a quick word with your pharmacist or surgeon before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fasinu PS, Gutmann H, Schiller H, Bouic PJ, Rosenkranz B. The potential of Hypoxis hemerocallidea for herb-drug interaction. Pharm Biol. 2013 Dec;51(12):1499-507.
Moderate

ORGANIC ANION TRANSPORTER 1 (OAT1) SUBSTRATES

2 of 2

Nepafenac also falls under ORGANIC ANION TRANSPORTER 1 (OAT1) SUBSTRATES.

In vitro research shows that African wild potato extract inhibits OAT1. This drug transport protein is involved in renal tubular uptake of some drugs from the blood and then elimination in the urine. Inhibition of this transporter decreases renal elimination and increases drug levels in the body. The clinical significance of this in humans is not known.
Some substrates of OAT1 include acyclovir (Zovirax), adefovir (Hepsera), cephalosporins, cidofovir (Vistide), cimetidine (Tagamet), ciprofloxacin (Cipro), furosemide (Lasix), hydrochlorothiazide (HCTZ), NSAIDs, oseltamivir (Tamiflu), pravastatin (Pravachol), probenecid, simvastatin (Zocor), and zidovudine (Retrovir).
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the good news on this one. The concern with African Wild Potato is that, in lab tests, it can block a kidney transporter called OAT1 that helps clear certain drugs out through your urine. When that transporter is slowed down, blood levels of those drugs can creep up. But Nepafenac is an eye drop, used right on the surface of the eye after cataract surgery to ease pain, redness, and swelling. Very little gets into your bloodstream, so a kidney-clearance interaction really doesn't have much to act on.

On top of that, this whole interaction comes only from test-tube research, with no proof it matters in real people. I wouldn't lose sleep over it. Still, it's always smart to mention any supplement to your pharmacist or surgeon, just so your full picture is on record.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fasinu PS, Gutmann H, Schiller H, Bouic PJ, Rosenkranz B. The potential of Hypoxis hemerocallidea for herb-drug interaction. Pharm Biol. 2013 Dec;51(12):1499-507.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

African Wild Potato Also Interacts With Other Medications

African Wild Potato has 1,004 moderate known drug interactions in our database — the Nepafenac one above is among them. If you take anything else, check it against the full list below.

Moderate 1,004 No known interaction 1,826 (incl. Nepafenac)
Taking anything else?

Check Another of Your Medications Against African Wild Potato

Covers the 2,830 medications we’ve checked against African Wild Potato. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Nepafenac

This page covers African Wild Potato only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Nepafenac page lists 9 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Wine (major), Banderol (moderate), Caffeic Acid (moderate) and Caprylic Acid (moderate).

By severity: 2 major · 6 moderate · 1 minor.

From our pharmacist’s overview on the Nepafenac page

“Nepafenac (Nevanac, Ilevro) is an anti-inflammatory eye drop given after cataract surgery, and enough of it is absorbed to act like an NSAID throughout the body. Its interaction list is short, nine ingredients in all, but it warrants real vigilance because the two rated major both involve alcohol.”

Reviewed by 2 · Jul 18, 2026

Open the Nepafenac interaction page

One more smart check

Taking African Wild Potato as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing African Wild Potato, each one broken down to its full ingredient list — and combination products often carry several ingredients besides African Wild Potato. Your product may carry other ingredients that interact with Nepafenac too, on top of African Wild Potato — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where African Wild Potato and Nepafenac Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement African Wild Potato
Top half

#415 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Nepafenac
Top half

#1,372 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About African Wild Potato

What is African Wild Potato?

  • Immune support
  • Prostate and urinary symptoms
  • Inflammation
  • General tonic/wellness
  • Skin conditions

African Wild Potato (Hypoxis hemerocallidea) is a southern African plant traditionally used as a tonic and for immune, prostate, and inflammatory complaints. Human evidence for these uses is very limited, and safety—especially during pregnancy, breastfeeding, or with serious illness—is not well established. Talk to a pharmacist or doctor before using it.

Read the full African Wild Potato monograph & all interactions
Medication

About Nepafenac Ophthalmic

What Is Nepafenac Ophthalmic Used For?

Brand names: Nevanac, Ilevro

Nepafenac ophthalmic eye drops are used to relieve pain and reduce inflammation in the eye following cataract surgery. Ilevro 0.3% is specifically indicated for this purpose.

See full Nepafenac Ophthalmic drug information
Keep checking

Other Drugs & African Wild Potato

Browse every other medication we’ve checked against African Wild Potato — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1,004Moderate
0Minor
1,825No known interaction
1,004 Moderate 1,825 No interaction
Moderate

1,004 interactions

Showing 60 of 1,004 moderate interactions — see all 1,004 on the African Wild Potato page.

No interaction 1,825 drugs checked — show the list

We also checked African Wild Potato against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,825 medications checked with no known interaction — see the full African Wild Potato list.

See the full African Wild Potato interactions page
See every supplement checked against Nepafenac, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
African Wild Potato monograph › Uses, safety, and every drug interaction in one place Nepafenac supplement interactions › Every supplement checked against Nepafenac, ranked by severity Nepafenac Ophthalmic drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking African Wild Potato and Nepafenac Together: Common Questions

Can you take African Wild Potato with Nepafenac?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for African Wild Potato and Nepafenac?
Nepafenac belongs to more than one drug category, and African Wild Potato interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the African Wild Potato and Nepafenac interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Nepafenac and African Wild Potato?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.