Medication interaction hub

What Supplements Interact with Nepafenac?

Nepafenac brand names: Nevanac, Ilevro. Every interaction below applies to the brands too.

9 Interactions 2 Major 6 Moderate 1 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Nepafenac? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Nepafenac against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Nepafenac (Nevanac, Ilevro) is an anti-inflammatory eye drop given after cataract surgery, and enough of it is absorbed to act like an NSAID throughout the body. Its interaction list is short, nine ingredients in all, but it warrants real vigilance because the two rated major both involve alcohol. Beer and wine each raise the risk of stomach and intestinal bleeding when combined with any NSAID, this one included.

Most of the six moderate entries inhibit kidney transporters, proteins called OAT1 and OAT3 that pull the drug out of the blood for elimination, so blocking them could let its levels creep upward; quercetin is the most familiar of these. The remaining moderates overlap with nepafenac's NSAID effects in other ways, and a lone minor entry completes the nine. Settle the alcohol question first, since that is where the serious risk lives.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 6 Minor 1 No known interaction 1,443

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Nepafenac: Top Interactions at a Glance

The most significant Nepafenac supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 9 highest-ranked of 9 interacting ingredients — plus 1,443 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Nepafenac + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Beer + Nepafenaci

Concomitant use may increase the risk of gastrointestinal (GI) bleeding.

Read the full interaction Major Likelihood Probable Wine + Nepafenaci

Concomitant use may increase the risk of gastrointestinal (GI) bleeding.

Read the full interaction
The complete list

Every Supplement Checked Against Nepafenac

All 1,452 ingredients in our database, ranked by severity — 9 with a Nepafenac interaction on file and 1,443 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Nepafenac?

One-line answers, one card per combination — scroll through today’s 10 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Chromium with Nepafenac?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. NSAIDs might increase chromium levels in the body.

Full Chromium + Nepafenac answer

Can you take Caprylic Acid with Nepafenac?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caprylic acid might increase plasma concentrations of NSAIDs.

Full Caprylic Acid + Nepafenac answer

Can you take Quercetin with Nepafenac?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the effects and adverse effects of OAT3 substrates.

Full Quercetin + Nepafenac answer

Can you take Beer with Nepafenac?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase the risk of gastrointestinal (GI) bleeding.

Full Beer + Nepafenac answer

Can you take Wine with Nepafenac?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase the risk of gastrointestinal (GI) bleeding.

Full Wine + Nepafenac answer

Can you take Lithium with Nepafenac?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking lithium supplements with NSAIDs might increase lithium levels and adverse effects.

Full Lithium + Nepafenac answer

Can you take African Wild Potato with Nepafenac?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence shows that African wild potato extract inhibits OAT3.

Full African Wild Potato + Nepafenac answer

Can you take Banderol with Nepafenac?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Small lab studies have found that Banderol may also inhibit OATP1B3 (Organic Anion Transporting Polypeptide 1B3), in addition to OATP1B1.

Full Banderol + Nepafenac answer

Can you take Caffeic Acid with Nepafenac?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeic acid might increase the levels and clinical effects of OAT3 substrates.

Full Caffeic Acid + Nepafenac answer

Can you take Quercetin with Nepafenac?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the effects and adverse effects of OAT3 substrates.

Full Quercetin + Nepafenac answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Nepafenac is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Nepafenac, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Nepafenac sits in 3 interaction categories. Open any one to see what the group means:

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Nepafenac through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Nepafenac through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Nepafenac through this category.

About Nepafenac

Nepafenac ophthalmic is a nonsteroidal anti-inflammatory (NSAID) eye drop used to treat pain and inflammation associated with cataract surgery.

Generic name: Nepafenac  ·  Brand names: Nevanac, Ilevro.

See the full Nepafenac Ophthalmic drug information

Related: does Nepafenac deplete any nutrients?

Nepafenac has 2 reported nutrient associations in the research literature — see the Nepafenac nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Nepafenac

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Nepafenac.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Prefer typing? The interaction checker looks up products by name too.

Products that contain Nepafenac-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Nepafenac.

ModuProst by Nature's Harmony contains African Wild Potato
Pharmacist Counseling Corner

Nepafenac & Supplements: Common Questions

What supplements interact with Nepafenac?
Our database currently documents 9 ingredients with a known Nepafenac interaction (2 major, 6 moderate, 1 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 9. The highest-ranked right now: Beer, Wine, Lithium.
Which Nepafenac supplement interactions are the most serious?
Focus on the major group: Beer and Wine. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Nepafenac?
Plenty of supplements coexist fine with Nepafenac; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Nevanac have the same supplement interactions as Nepafenac?
Yes — Nevanac, Ilevro all contain Nepafenac, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Nepafenac deplete any vitamins or nutrients?
It might — Nepafenac has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Nepafenac nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Nepafenac and my other medications?
This page covers Nepafenac against supplements and herbal ingredients. Checking Nepafenac against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Nepafenac Ophthalmic drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.