Drug & supplement interaction

African Wild Potato + Naproxen Sodium

Naproxen Sodium brand name: Midol Extended Relief.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Naproxen Sodium falls into 4 drug categories that African Wild Potato can interact with; the most serious is rated moderate. In vitro evidence shows that African wild potato extract inhibits OAT3.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions4
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

African Wild Potato and Naproxen Sodium

These two interact in 4 distinct ways. Each one is explained separately below.

Why Are There 4 Interactions?

African Wild Potato interacts with whole categories of medication. Naproxen Sodium falls into 4 of those categories, so it can interact with African Wild Potato in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES

1 of 4

Why this applies to Naproxen Sodium

Naproxen Sodium falls under ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES — the group African Wild Potato interacts with.

In vitro evidence shows that African wild potato extract inhibits OAT3. This drug transport protein is involved in renal tubular uptake of some drugs from the blood and then elimination in the urine. Inhibition of this transporter decreases renal elimination and increases drug levels in the body. The clinical significance of this in humans is not known.
Some substrates of OAT3 include cephalosporins, famotidine (Pepcid), furosemide (Lasix), hydrochlorothiazide (HCTZ), methotrexate, NSAIDs, probenecid, ranitidine (Zantac).
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Your kidneys help clear naproxen out of your body, partly through a little transporter called OAT3. In test-tube studies, African Wild Potato seems to block that transporter. If the same thing happened in people, your kidneys might flush naproxen out a bit more slowly, letting it build up a little higher than usual.

With more naproxen hanging around, you could see more of its typical side effects: stomach upset or heartburn, a higher chance of stomach irritation or bleeding, fluid retention, and added strain on the kidneys. Here's the honest part though: this is based only on lab work, not real people, so we truly don't know if it matters in everyday use. Still, it's worth a quick chat with your pharmacist or doctor before combining the two, especially if you take naproxen regularly.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fasinu PS, Gutmann H, Schiller H, Bouic PJ, Rosenkranz B. The potential of Hypoxis hemerocallidea for herb-drug interaction. Pharm Biol. 2013 Dec;51(12):1499-507.
Moderate

ORGANIC ANION TRANSPORTER 1 (OAT1) SUBSTRATES

2 of 4

Naproxen Sodium also falls under ORGANIC ANION TRANSPORTER 1 (OAT1) SUBSTRATES.

In vitro research shows that African wild potato extract inhibits OAT1. This drug transport protein is involved in renal tubular uptake of some drugs from the blood and then elimination in the urine. Inhibition of this transporter decreases renal elimination and increases drug levels in the body. The clinical significance of this in humans is not known.
Some substrates of OAT1 include acyclovir (Zovirax), adefovir (Hepsera), cephalosporins, cidofovir (Vistide), cimetidine (Tagamet), ciprofloxacin (Cipro), furosemide (Lasix), hydrochlorothiazide (HCTZ), NSAIDs, oseltamivir (Tamiflu), pravastatin (Pravachol), probenecid, simvastatin (Zocor), and zidovudine (Retrovir).
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: your kidneys help clear naproxen out of your body, partly through a transporter called OAT1. In lab dish studies, African wild potato seems to block that transporter. If that happened in a real person, naproxen might leave the body a bit slower and build up slightly higher than usual.

With more naproxen hanging around, you could see more of its typical downsides, things like stomach upset or irritation, heartburn, fluid retention, higher blood pressure, or added strain on the kidneys. The honest truth, though, is that this is only test-tube evidence, so we don't know if it matters in people at all. I wouldn't lose sleep over it, but since both can be hard on the kidneys and stomach, it's worth a quick chat with your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fasinu PS, Gutmann H, Schiller H, Bouic PJ, Rosenkranz B. The potential of Hypoxis hemerocallidea for herb-drug interaction. Pharm Biol. 2013 Dec;51(12):1499-507.
Moderate

CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES

3 of 4

Naproxen Sodium also falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES.

In vitro research shows that African wild potato extract inhibits cytochrome P450 1A2 (CYP1A2). However, this effect has yet to be reported in humans. Until more is known, use with caution. Theoretically, concomitant use of African wild potato with CYP1A2 substrates might increase the risk for adverse effects from these substrates. Some of these drugs include amitriptyline (Elavil), haloperidol (Haldol), ondansetron (Zofran), propranolol (Inderal), theophylline (Theo-Dur, others), verapamil (Calan, Isoptin, others), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for naproxen sodium. Your liver uses an enzyme called CYP1A2 to help break this pain reliever down. In a test-tube study, African wild potato seemed to slow that enzyme. If the same thing happened in people, naproxen could clear a little more slowly and linger in your system, which might nudge up the usual side effects, things like stomach upset, heartburn, or in some cases stomach irritation or bleeding.

But I want to keep this in perspective. This was only seen in lab dishes, never confirmed in real patients, so it stays theoretical for now. Still, since naproxen already can be hard on the stomach, it's worth a quick chat with your pharmacist or doctor before pairing the two, especially with concentrated supplement doses.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fasinu PS, Gutmann H, Schiller H, Bouic PJ, Rosenkranz B. The potential of Hypoxis hemerocallidea for herb-drug interaction. Pharm Biol. 2013 Dec;51(12):1499-507.
Moderate

CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES

4 of 4

Naproxen Sodium also falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES.

In vitro research shows that African wild potato extract inhibits cytochrome P450 2C9 (CYP2C9). However, this effect has yet to be reported in humans. Until more is known, use with caution. Theoretically, concomitant use of African wild potato with CYP2C9 substrates might increase the risk for adverse effects from these substrates. Some of these drugs include nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), and piroxicam (Feldene); celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with naproxen and African wild potato. Your liver uses an enzyme called CYP2C9 to help clear naproxen out of your system. In test-tube studies, African wild potato seems to slow that same enzyme down. If that also happened in people, naproxen could hang around a bit longer and build up, which might nudge up the usual NSAID side effects: stomach upset or irritation, a higher chance of stomach bleeding, fluid retention, raised blood pressure, or stress on the kidneys.

The honest part is that this is only seen in lab studies so far, not in actual patients, so the real-world risk is uncertain and probably modest for most folks. Still, since both can be hard on the stomach, it's worth a quick chat with your pharmacist or doctor before pairing them, especially if you take naproxen often.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fasinu PS, Gutmann H, Schiller H, Bouic PJ, Rosenkranz B. The potential of Hypoxis hemerocallidea for herb-drug interaction. Pharm Biol. 2013 Dec;51(12):1499-507.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

African Wild Potato Also Interacts With Other Medications

African Wild Potato has 1,004 moderate known drug interactions in our database — the Naproxen Sodium one above is among them. If you take anything else, check it against the full list below.

Moderate 1,004 No known interaction 1,826 (incl. Naproxen Sodium)
Taking anything else?

Check Another of Your Medications Against African Wild Potato

Covers the 2,830 medications we’ve checked against African Wild Potato. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Naproxen Sodium

This page covers African Wild Potato only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Naproxen Sodium page lists 311 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

Open the Naproxen Sodium interaction page

One more smart check

Taking African Wild Potato as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing African Wild Potato, each one broken down to its full ingredient list — and combination products often carry several ingredients besides African Wild Potato. Your product may carry other ingredients that interact with Naproxen Sodium too, on top of African Wild Potato — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where African Wild Potato and Naproxen Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement African Wild Potato
Top half

#566 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Naproxen Sodium
Steady interest

#1,986 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About African Wild Potato

What is African Wild Potato?

  • Immune support
  • Prostate and urinary symptoms
  • Inflammation
  • General tonic/wellness
  • Skin conditions

African Wild Potato (Hypoxis hemerocallidea) is a southern African plant traditionally used as a tonic and for immune, prostate, and inflammatory complaints. Human evidence for these uses is very limited, and safety—especially during pregnancy, breastfeeding, or with serious illness—is not well established. Talk to a pharmacist or doctor before using it.

Read the full African Wild Potato monograph & all interactions
Keep checking

Other Drugs & African Wild Potato

Browse every other medication we’ve checked against African Wild Potato — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1,004Moderate
0Minor
1,825No known interaction
1,004 Moderate 1,825 No interaction
Moderate

1,004 interactions

Showing 60 of 1,004 moderate interactions — see all 1,004 on the African Wild Potato page.

No interaction 1,825 drugs checked — show the list

We also checked African Wild Potato against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,825 medications checked with no known interaction — see the full African Wild Potato list.

See the full African Wild Potato interactions page
See every supplement checked against Naproxen Sodium, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
African Wild Potato monograph › Uses, safety, and every drug interaction in one place Naproxen Sodium supplement interactions › Every supplement checked against Naproxen Sodium, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking African Wild Potato and Naproxen Sodium Together: Common Questions

Can you take African Wild Potato with Naproxen Sodium?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 4 interactions listed for African Wild Potato and Naproxen Sodium?
Naproxen Sodium belongs to more than one drug category, and African Wild Potato interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the African Wild Potato and Naproxen Sodium interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Naproxen Sodium and African Wild Potato?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.