4-androsterone + Conjugated Estrogens, Methyltestosterone
Conjugated Estrogens, Methyltestosterone brand name: Premarin with Methyltestosterone.
4-androsterone has a moderate interaction with Conjugated Estrogens, Methyltestosterone. 4-Androsterone is purportedly converted to testosterone and other androgens upon ingestion.
Read the full interaction report4-androsterone and Conjugated Estrogens, Methyltestosterone
Here is the interaction we found between these two, with the evidence behind it.
TESTOSTERONE
Why this applies to Conjugated Estrogens, Methyltestosterone
Conjugated Estrogens, Methyltestosterone falls under TESTOSTERONE — the group 4-androsterone interacts with.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the simple version. Your medication already contains methyltestosterone, which is a form of testosterone. 4-Androsterone is a prohormone, meaning your body can convert it into testosterone and similar androgens. So stacking the two basically piles more androgen on top of what you're already taking.
When androgen levels run high, you can see more of the usual testosterone-type effects: mood swings or irritability, acne or oily skin, fluid retention, and strain on the liver and cholesterol levels over time. This is a theoretical concern based on how these compounds work, not proven from studies, but the logic is sound. Please loop in your doctor or pharmacist before combining them so they can keep an eye on your liver and heart health.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
4-androsterone Also Interacts With Other Medications
4-androsterone has 7 moderate known drug interactions in our database — the Conjugated Estrogens, Methyltestosterone one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against 4-androsterone
We haven’t checked that one against 4-androsterone yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against 4-androsterone. Pick one to open its full report.
See Every Supplement That Interacts With Conjugated Estrogens, Methyltestosterone
This page covers 4-androsterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Conjugated Estrogens, Methyltestosterone page lists 226 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).
By severity: 6 major · 184 moderate · 36 minor.
From our pharmacist’s overview on the Conjugated Estrogens, Methyltestosterone page
“If you take conjugated estrogens with methyltestosterone (Premarin with Methyltestosterone), a hormone combination used for menopausal symptoms, read the six major-rated entries here before adding any supplement. Most of the 226 ingredients on file change how your body handles the hormones themselves.”
Reviewed by 2 · Jul 18, 2026
Open the Conjugated Estrogens, Methyltestosterone interaction page
Taking 4-androsterone as Part of a Dietary Supplement Product? Check It for Interactions
We hold 23 real supplement products containing 4-androsterone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 4-androsterone. Your product may carry other ingredients that interact with Conjugated Estrogens, Methyltestosterone too, on top of 4-androsterone — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where 4-androsterone and Conjugated Estrogens, Methyltestosterone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#448 of 1,452 supplements looked up here in the last 7 days
#850 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About 4-androsterone
What is 4-androsterone?
- Muscle building
- Strength and athletic performance
- Boosting testosterone
- Bodybuilding cycles
4-Androsterone (sometimes called 4-DHEA) is a lab-made prohormone marketed to bodybuilders as a way to raise testosterone and build muscle, but human studies are very limited and it carries real risks like liver strain, hormone imbalance, and cholesterol changes. Its legal status is uncertain in many places, and it may cause a positive result on drug tests. We do not recommend it without close medical supervision, and it should be avoided in pregnancy and breastfeeding.
Other Drugs & 4-androsterone
Browse every other medication we’ve checked against 4-androsterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
7 interactions
No interaction 2,822 drugs checked — show the list
We also checked 4-androsterone against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Warfarin Sodium ›
- Tirzepatide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Acyclovir ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Fluoxetine ›
- Lamotrigine ›
- Acetaminophen, Codeine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Dextroamphetamine ›
- Azithromycin ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Methylene Blue ›
- Quetiapine ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,822 medications checked with no known interaction — see the full 4-androsterone list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Conjugated Estrogens, Methyltestosterone Is Linked to Lower Levels of 5 Nutrients
Natural Medicines records Conjugated Estrogens, Methyltestosterone as a medicine that can lower these. This is not an interaction with 4-androsterone — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Conjugated Estrogens, Methyltestosterone nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking 4-androsterone and Conjugated Estrogens, Methyltestosterone Together: Common Questions
Can you take 4-androsterone with Conjugated Estrogens, Methyltestosterone?
How serious is the 4-androsterone and Conjugated Estrogens, Methyltestosterone interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Conjugated Estrogens, Methyltestosterone and 4-androsterone?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.