Drug & supplement interaction

Andarine + Letrozole

Letrozole brand name: Femara.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Andarine and Letrozole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Andarine and Letrozole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Letrozole and Andarine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Andarine safety at a glance

Andarine overall Avoid Andarine is an unapproved drug with unknown human safety and is not a legal supplement.
Pregnancy Avoid A hormone-affecting drug like this should never be used during pregnancy.
Breastfeeding Avoid It is unsafe and unstudied during breastfeeding and should be avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Letrozole and Andarine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Letrozole

Interactions in our licensed database are recorded against drug classes, not just single drug names. Letrozole is filed under 4 classifications — including aromatase inhibitors, cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 3a4 (cyp3a4) substrates. Andarine has documented interactions with 1 drug class — the most serious being androgens (moderate) — and none of Letrozole’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Andarine Does Interact With Other Medications

Andarine has 9 moderate known drug interactions in our database — Letrozole isn’t one of them. If you take anything else, check it against the full list below.

Moderate 9 No known interaction 2,821 (incl. Letrozole)
Taking anything else?

Check Another of Your Medications Against Andarine

Covers the 2,830 medications we’ve checked against Andarine. Pick one to open its full report.

What to actually watch for

What Andarine Itself Has Been Linked To

This is not an interaction — nothing below involves Letrozole. It is the side-effect record for Andarine on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Andarine, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • A heart attack Worth acting on Additional detail

    “Orally, selective androgen receptor modulators, such as andarine, could potentially increase the risk of myocardial infarction, stroke, and liver toxicity. However, no thorough safety evaluations of andarine have been conducted.”

    Andarine · Natural Medicines adverse-effect record, reported in myocardial infarction (mi).

    1 source cited
    1. 98840. FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.

    “The FDA has warned that selective androgen receptor modulators, such as andarine, could potentially increase the risk of myocardial infarction and stroke.”

    Andarine · Natural Medicines adverse-effect record, reported in myocardial infarction (mi).

    1 source cited
    1. 98840. FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.
  • Liver problems Worth acting on Additional detail

    Recorded for Andarine in the same Natural Medicines adverse-effect record shown under A heart attack above.

Everything above comes from the Natural Medicines adverse-effect record for Andarine — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Letrozole’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Letrozole column appears here.

From our Q&A

Questions About Andarine or Letrozole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Andarine or Letrozole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Letrozole

This page covers Andarine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Letrozole page lists 142 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), 7-methoxyflavone (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 99 moderate · 40 minor.

From our pharmacist’s overview on the Letrozole page

“Letrozole (Femara) is prescribed to keep hormone-driven breast cancer from returning, so a supplement that shifts its blood level can quietly undercut treatment. Give this list of 142 ingredients genuine respect, and learn the three major entries first.”

Reviewed by 2 · Jul 18, 2026

Open the Letrozole interaction page

One more smart check

Taking Andarine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 13 real supplement products containing Andarine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Andarine. Even though Andarine itself has no known interaction with Letrozole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Andarine and Letrozole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Andarine
Steady interest

#1,088 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Letrozole
Top 5%

#50 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Andarine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Andarine and Letrozole records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Andarine

What is Andarine?

Andarine
  • Muscle building
  • Strength gains
  • Fat loss / body recomposition
  • Athletic performance enhancement
  • Bone density support

Andarine (S-4) is a synthetic selective androgen receptor modulator (SARM) that is not approved by the FDA for human use and is banned in sports. It is not a legal dietary supplement ingredient, its long-term safety in people is unknown, and reported side effects include vision changes and possible liver and hormone problems. Because of these risks and its illegal status, we do not recommend using it.

Not applicable (synthetic chemical compound) · Capsules, tablets, liquid solutions (sold as research chemicals)

An interaction check asks whether these two react with each other — it does not ask whether Andarine is a good idea for someone in your situation. Here is what our Andarine record says about it on its own.

Andarine: dosing

There is no established or approved dose for Andarine because it is not a recognized medicine or legal supplement. We cannot recommend a safe dose, and doses circulated online are not backed by proper human research.Given that it is unapproved, potentially unsafe, and illegal to sell as a supplement, the safest choice is not to use it at all.

From our Andarine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Andarine monograph & all interactions
Medication

About Letrozole

What Is Letrozole Used For?

Brand name: Femara

Letrozole (brand name Femara) is used to treat breast cancer in postmenopausal women whose tumors are driven by estrogen. It is used in three settings: as adjuvant (after-surgery) treatment for hormone receptor positive early breast cancer; as extended adjuvant treatment for women who have already completed about five years of tamoxifen therapy; and as first- or second-line treatment for locally advanced or metastatic (spread) breast cancer.

Femara is specifically indicated for first-line treatment of hormone receptor positive or receptor-unknown locally advanced or metastatic breast cancer, and for advanced breast cancer in women whose disease has progressed after antiestrogen therapy.

See full Letrozole drug information
Keep checking

Other Drugs & Andarine

Browse every other medication we’ve checked against Andarine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
9Moderate
0Minor
2,820No known interaction
9 Moderate 2,820 No interaction
Moderate

9 interactions

No interaction 2,820 drugs checked — show the list

We also checked Andarine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,820 medications checked with no known interaction — see the full Andarine list.

See the full Andarine interactions page
See every supplement checked against Letrozole, ranked by severity
Evidence & sources

Andarine References

The 1 references that drive our Andarine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Andarine and Letrozole Together: Common Questions

Is it safe to take Andarine with Letrozole?
We do not list a known interaction between Andarine and Letrozole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Andarine and Letrozole combination checked?
Interactions in our licensed database are recorded against drug classes. Letrozole is filed under 4 classifications, and Andarine has documented interactions with 1 drug class — none of Letrozole's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Andarine interact with any other medications?
Yes. Andarine has 9 documented drug interactions in our database — Letrozole is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Letrozole interact with any supplements?
Yes. Letrozole has documented interactions with 142 supplements in our database — Andarine is not one of them. The Letrozole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Andarine monograph Uses, safety profile, and every drug interaction in one place Letrozole drug information The full plain-English guide to this medication Letrozole supplement interactions Every supplement checked against Letrozole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Letrozole and Andarine?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.