Drug & supplement interaction

Andarine + Glyburide, Metformin

Glyburide, Metformin brand name: Glucovance.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Andarine and Glyburide, Metformin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Glyburide, Metformin states a food rule worth keeping to.

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Interaction report

Andarine and Glyburide, Metformin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Glyburide, Metformin and Andarine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Andarine safety at a glance

Andarine overall Avoid Andarine is an unapproved drug with unknown human safety and is not a legal supplement.
Pregnancy Avoid A hormone-affecting drug like this should never be used during pregnancy.
Breastfeeding Avoid It is unsafe and unstudied during breastfeeding and should be avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Glyburide, Metformin and Andarine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Glyburide, Metformin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Glyburide, Metformin is filed under 10 classifications — including sulfonylureas, organic cation transporter 2 (oct2) substrates, organic anion-transporting polypeptide substrates (oatp). Andarine has documented interactions with 1 drug class — the most serious being androgens (moderate) — and none of Glyburide, Metformin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Andarine Does Interact With Other Medications

Andarine has 9 moderate known drug interactions in our database — Glyburide, Metformin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 9 No known interaction 2,821 (incl. Glyburide, Metformin)
Taking anything else?

Check Another of Your Medications Against Andarine

Covers the 2,830 medications we’ve checked against Andarine. Pick one to open its full report.

What to actually watch for

What Andarine Itself Has Been Linked To

This is not an interaction — nothing below involves Glyburide, Metformin. It is the side-effect record for Andarine on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Andarine, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • A heart attack Worth acting on Additional detail

    “Orally, selective androgen receptor modulators, such as andarine, could potentially increase the risk of myocardial infarction, stroke, and liver toxicity. However, no thorough safety evaluations of andarine have been conducted.”

    Andarine · Natural Medicines adverse-effect record, reported in myocardial infarction (mi).

    1 source cited
    1. 98840. FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.

    “The FDA has warned that selective androgen receptor modulators, such as andarine, could potentially increase the risk of myocardial infarction and stroke.”

    Andarine · Natural Medicines adverse-effect record, reported in myocardial infarction (mi).

    1 source cited
    1. 98840. FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.
  • Liver problems Worth acting on Additional detail

    Recorded for Andarine in the same Natural Medicines adverse-effect record shown under A heart attack above.

Everything above comes from the Natural Medicines adverse-effect record for Andarine — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Glyburide, Metformin’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Glyburide, Metformin column appears here.

How to take them

Some Glyburide, Metformin Products Have a Food Rule — Andarine Should Not Break It

At least one FDA label for a product containing Glyburide, Metformin says to take it with food. If you take Andarine on an empty stomach out of habit, keep them separate — and take Glyburide, Metformin with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Glyburide, Metformin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

For patients with type 2 diabetes whose hyperglycemia cannot be satisfactorily managed with diet and exercise alone, the recommended starting dose is 1.25 mg glyburide and 250 mg metformin hydrochloride once a day with a meal.

From the Dosage and Administration section of the FDA label we read for Glyburide, Metformin — where that label names a specific product, the instruction is that product's.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Glyburide, Metformin

This page covers Andarine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glyburide, Metformin page lists 332 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Beer (major), Grapefruit (major) and Siberian Cocklebur (major).

By severity: 7 major · 281 moderate · 44 minor.

From our pharmacist’s overview on the Glyburide, Metformin page

“Glucovance combines glyburide and metformin to lower blood sugar, and its list of 332 interacting supplements deserves real care, starting with the seven rated major. Most entries, 239 of them, lower blood sugar on their own, so stacking one on top of a drug built to do exactly that can drop your glucose into dangerous territory.”

Reviewed by 2 · Jul 18, 2026

Open the Glyburide, Metformin interaction page

One more smart check

Taking Andarine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 13 real supplement products containing Andarine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Andarine. Even though Andarine itself has no known interaction with Glyburide, Metformin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Andarine and Glyburide, Metformin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Andarine
Steady interest

#1,081 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Glyburide, Metformin
Steady interest

#1,602 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Andarine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Andarine and Glyburide, Metformin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Andarine

What is Andarine?

Andarine
  • Muscle building
  • Strength gains
  • Fat loss / body recomposition
  • Athletic performance enhancement
  • Bone density support

Andarine (S-4) is a synthetic selective androgen receptor modulator (SARM) that is not approved by the FDA for human use and is banned in sports. It is not a legal dietary supplement ingredient, its long-term safety in people is unknown, and reported side effects include vision changes and possible liver and hormone problems. Because of these risks and its illegal status, we do not recommend using it.

Not applicable (synthetic chemical compound) · Capsules, tablets, liquid solutions (sold as research chemicals)

An interaction check asks whether these two react with each other — it does not ask whether Andarine is a good idea for someone in your situation. Here is what our Andarine record says about it on its own.

Andarine: dosing

There is no established or approved dose for Andarine because it is not a recognized medicine or legal supplement. We cannot recommend a safe dose, and doses circulated online are not backed by proper human research.Given that it is unapproved, potentially unsafe, and illegal to sell as a supplement, the safest choice is not to use it at all.

From our Andarine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Andarine monograph & all interactions
Keep checking

Other Drugs & Andarine

Browse every other medication we’ve checked against Andarine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
9Moderate
0Minor
2,820No known interaction
9 Moderate 2,820 No interaction
Moderate

9 interactions

No interaction 2,820 drugs checked — show the list

We also checked Andarine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,820 medications checked with no known interaction — see the full Andarine list.

See the full Andarine interactions page
See every supplement checked against Glyburide, Metformin, ranked by severity
Evidence & sources

Andarine References

The 1 references that drive our Andarine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Andarine and Glyburide, Metformin Together: Common Questions

Is it safe to take Andarine with Glyburide, Metformin?
We do not list a known interaction between Andarine and Glyburide, Metformin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Andarine and Glyburide, Metformin at the same time of day?
At least one FDA label for a product containing Glyburide, Metformin says to take it with food. If you take Andarine on an empty stomach out of habit, keep them separate and take Glyburide, Metformin with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Glyburide, Metformin products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Andarine and Glyburide, Metformin combination checked?
Interactions in our licensed database are recorded against drug classes. Glyburide, Metformin is filed under 10 classifications, and Andarine has documented interactions with 1 drug class — none of Glyburide, Metformin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Andarine interact with any other medications?
Yes. Andarine has 9 documented drug interactions in our database — Glyburide, Metformin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Glyburide, Metformin interact with any supplements?
Yes. Glyburide, Metformin has documented interactions with 332 supplements in our database — Andarine is not one of them. The Glyburide, Metformin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Andarine monograph Uses, safety profile, and every drug interaction in one place Glyburide, Metformin supplement interactions Every supplement checked against Glyburide, Metformin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Glyburide, Metformin and Andarine?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.