Andarine + Tepotinib
Tepotinib brand name: Tepmetko.
We found no known interaction between Andarine and Tepotinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tepotinib states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Andarine and Tepotinib
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Tepotinib and Andarine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Andarine safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Tepotinib
Interactions in our licensed database are recorded against drug classes, not just single drug names. Tepotinib is filed under 3 classifications — p-glycoprotein substrates, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Andarine has documented interactions with 1 drug class — the most serious being androgens (moderate) — and none of Tepotinib’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Andarine Does Interact With Other Medications
Andarine has 9 moderate known drug interactions in our database — Tepotinib isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Andarine
We haven’t checked that one against Andarine yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Andarine. Pick one to open its full report.
Some Tepotinib Products Have a Food Rule — Andarine Should Not Break It
At least one FDA label for a product containing Tepotinib says to take it with food. If you take Andarine on an empty stomach out of habit, keep them separate — and take Tepotinib with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tepotinib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
( 2.1 , 14 ) Recommended dosage : 450 mg orally once daily with food until disease progression or unacceptable toxicity.
From the Dosage and Administration section of the FDA label we read for Tepotinib — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Tepotinib
This page covers Andarine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tepotinib page lists 144 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 103 moderate · 38 minor.
From our pharmacist’s overview on the Tepotinib page
“The supplement list for tepotinib (Tepmetko), a targeted lung cancer drug, is one I would treat carefully rather than skim. Nearly everything on it touches the same liver enzyme, CYP3A4, that clears tepotinib from the body, so some products can raise its level and its side effects while others quietly lower it and weaken the treatment…”
Reviewed by 2 · Jul 18, 2026
Taking Andarine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 13 real supplement products containing Andarine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Andarine. Even though Andarine itself has no known interaction with Tepotinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Andarine and Tepotinib Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,059 of 1,452 supplements looked up here in the last 7 days
#1,193 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Andarine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Andarine and Tepotinib records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Andarine
What is Andarine?
- Muscle building
- Strength gains
- Fat loss / body recomposition
- Athletic performance enhancement
- Bone density support
Andarine (S-4) is a synthetic selective androgen receptor modulator (SARM) that is not approved by the FDA for human use and is banned in sports. It is not a legal dietary supplement ingredient, its long-term safety in people is unknown, and reported side effects include vision changes and possible liver and hormone problems. Because of these risks and its illegal status, we do not recommend using it.
Not applicable (synthetic chemical compound) · Capsules, tablets, liquid solutions (sold as research chemicals)
An interaction check asks whether these two react with each other — it does not ask whether Andarine is a good idea for someone in your situation. Here is what our Andarine record says about it on its own.
Andarine: dosing
There is no established or approved dose for Andarine because it is not a recognized medicine or legal supplement. We cannot recommend a safe dose, and doses circulated online are not backed by proper human research.Given that it is unapproved, potentially unsafe, and illegal to sell as a supplement, the safest choice is not to use it at all.
From our Andarine monograph — the full record covers uses, side effects and every documented interaction.
About Tepotinib
What Is Tepotinib Used For?
Brand name: Tepmetko
Tepmetko (tepotinib) is used to treat adults with metastatic non-small cell lung cancer (NSCLC) — lung cancer that has spread — whose tumors carry a specific genetic alteration called a MET exon 14 skipping mutation. A test on tumor tissue or blood is required to confirm this mutation before treatment begins.
This is a targeted therapy, meaning it works against a specific molecular driver of cancer growth rather than attacking all rapidly dividing cells.
Other Drugs & Andarine
Browse every other medication we’ve checked against Andarine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
9 interactions
No interaction 2,820 drugs checked — show the list
We also checked Andarine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Metoprolol ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,820 medications checked with no known interaction — see the full Andarine list.
Andarine References
The 1 references that drive our Andarine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Andarine and Tepotinib Together: Common Questions
Is it safe to take Andarine with Tepotinib?
Do Andarine and Tepotinib have any of the same side effects?
Should I take Andarine and Tepotinib at the same time of day?
How was the Andarine and Tepotinib combination checked?
Does Andarine interact with any other medications?
Does Tepotinib interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Tepotinib and Andarine?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.