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Dietary supplement

S-4 Andarine Ingredients & Drug Interactions

by Swoll Mafia

S-4 Andarine label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking S-4 Andarine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

S-4 Andarine is a dietary supplement by Swoll Mafia with 1 active ingredient. Its ingredients are commonly taken for muscle building, strength gains, fat loss / body recomposition.Based on those ingredients, 9 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Andarine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against S-4 Andarine by Swoll Mafia

Ask about any prescription or over-the-counter medication and we check it for interactions with S-4 Andarine by Swoll Mafia — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of S-4 Andarine by Swoll Mafia

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Andarine (also called S-4), an experimental selective androgen receptor modulator (SARM) — a compound designed to bind to male hormone receptors in the body. It's not approved by the FDA and isn't a regulated supplement.

The product also contains Creatine as an inactive ingredient.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Andarine product and its label doesn't state a use — see Andarine's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We hold no effectiveness data for Andarine in our database. Because it's an unapproved experimental drug without published human safety or efficacy studies, we can't say what it does or doesn't do in people.

The evidence, ingredient by ingredient Andarine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Andarine is an unapproved drug with unknown safety in humans. The FDA has warned that selective androgen receptor modulators like this one could raise the risk of heart attack and stroke.

Oral use could also potentially increase liver toxicity risk, though no thorough safety evaluations have been completed. This product should never be used during pregnancy — it's a hormone-affecting drug and unsafe for a developing baby.

It's also unsafe and unstudied during breastfeeding and should be avoided.

Side effects, ingredient by ingredient Andarine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Andarine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 9 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any androgens or male hormone medications, check with your pharmacist before using this product — Andarine may intensify androgenic side effects. Because this is an unapproved drug, discuss it with your doctor or pharmacist before combining it with any medication.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Andarine is not a legal supplement — it's an unapproved experimental drug. If you're considering it, talk with your doctor or pharmacist first.

It carries real cardiovascular and liver risks that haven't been fully studied in humans, and it's absolutely off-limits during pregnancy and breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about S-4 Andarine, straight from the product label.

Brand Swoll Mafia
Barcode (UPC) 851290958928
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2019
DSLD ID 200097
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for S-4 Andarine by Swoll Mafia, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
851290958928
IngredientAmount% DV
Andarine50 mg--

Other ingredients: Creatine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Administer 3 capsules once daily. Do not exceed 1 serving within 24 hours.

Precautions

Do not exceed 1 serving within 24 hours. Warning: Do not exceed recommended dosage. Consult with a physician before use.

Keep out of reach from children.

Do not administer if test subject is at risk or has health issues involving heart, kidney, liver, stroke, difficult urinating, depression, anxiety or seizure disorder.

All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following product. All customers must be 18 years old to purchase. Under no circumstance shall seller be liable for consequential damages, whether purchases claim contract, negligence, strict liability or otherwise. In purchasing this product the purchaser agrees to the above

For experimental use only Not for human consumption

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease or illness.

Seals/Symbols

Proudly made in the United States USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

S-4 Andarine by Swoll Mafia label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

S-4 Andarine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in S-4 Andarine by Swoll Mafia

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Andarine

Interacts with
9 drugs
50 mg per serving

Andarine (S-4) is a synthetic selective androgen receptor modulator (SARM) that is not approved by the FDA for human use and is banned in sports. It i...

Andarine monograph & interactions

Other (inactive) ingredients: Creatine. These complete the product’s ingredient list but are not active constituents.

Interaction report

S-4 Andarine by Swoll Mafia Drug Interactions

Want to check YOUR meds against S-4 Andarine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
9Drugs
9 Moderate

Ingredients driving the most interactions

Andarine 9

Individual Drug Interactions

The ingredients in S-4 Andarine interact with 9 drugs. Click any drug to see the details.

1 of the 1 ingredient in S-4 Andarine interact with drugs. Each result below shows which ingredient is responsible. Andarine

Each ingredient & the kinds of drugs it affects

For each ingredient in S-4 Andarine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Andarine1 drug type · 9 drugs

Androgens

Due to its androgenic properties, Andarine (S-4) may theoretically interact with other androgenic drugs, potentially increasing the risk of side effects associated with androgenic activity (source: https://pubmed.ncbi.nlm.nih.gov/12604714/). These side effects can include masculinization, virilization, acne, hair loss, increased libido, aggression, mood changes, and liver toxicity.

Likelihood Possible Evidence C
Andarine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for S-4 Andarine, from the product label.

Swoll Mafia

See all Swoll Mafia products
Name
Swoll Mafia
Pharmacist Counseling Corner

S-4 Andarine by Swoll Mafia: Common Questions

Does S-4 Andarine by Swoll Mafia interact with any medications?
Yes. Based on its ingredients, S-4 Andarine has a known interaction with 9 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
S-4 Andarine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Andarine legal?
No. Andarine is an unapproved experimental drug, not a legal supplement. The FDA has not approved it for any use in humans.
Can I use this while pregnant or breastfeeding?
No. Andarine is unsafe during pregnancy — it's a hormone-affecting drug. It's also unsafe and unstudied during breastfeeding. Do not use this product if you're pregnant, planning to become pregnant, or breastfeeding.
What are the side effects?
Andarine hasn't been thoroughly studied in humans, so a complete safety picture doesn't exist. The FDA warns that it could increase your risk of heart attack and stroke. It may also raise liver toxicity risk. Additionally, it could cause masculinization, acne, hair loss, increased libido, and aggression — especially if combined with other androgens.
Does this product contain anything besides Andarine?
The active ingredient is Andarine. The product also contains Creatine as an inactive ingredient (a filler).

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if S-4 Andarine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

S-4 Andarine label
Go deeper

The Full Monographs Behind S-4 Andarine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Andarine

Interacts with 9 drugs

Andarine (S-4) is a synthetic selective androgen receptor modulator (SARM) that is not approved by the FDA for human use and is banned in sports. It is not a legal dietary supplement ingredi...

Read the full Andarine monograph →
Sources

Sources & How We Checked

S-4 Andarine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Andarine 1 reference
  1. FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.

See these in context on the Andarine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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