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Dietary supplement

LGD4033 Ingredients & Drug Interactions

by Swoll Mafia

LGD4033 label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking LGD4033 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

LGD4033 is a dietary supplement by Swoll Mafia with 1 active ingredient. Its ingredients are commonly taken for muscle building, athletic performance and strength, body recomposition.Based on those ingredients, 370 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ligandrol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against LGD4033 by Swoll Mafia

Ask about any prescription or over-the-counter medication and we check it for interactions with LGD4033 by Swoll Mafia — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of LGD4033 by Swoll Mafia

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Swoll Mafia LGD4033 is a single-ingredient supplement containing ligandrol, a selective androgen receptor modulator (SARM) — a research compound designed to activate androgen receptors in muscle and bone. The capsule also includes creatine as an inactive ingredient.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Ligandrol product and its label doesn't state a use — see Ligandrol's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold on ligandrol does not establish reliable effectiveness for any condition we could rate. Claims about athletic performance, muscle strength, breast cancer, cachexia (severe muscle loss), and muscular dystrophy all lack sufficient reliable evidence in our data to rate.

The evidence, ingredient by ingredient Ligandrol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ligandrol is not an approved medication or a legal dietary supplement — it is an unapproved investigational drug. The FDA has warned that SARM-containing supplements, including those with ligandrol, carry real safety concerns.

Multiple case reports document liver injury linked to ligandrol use, including a case where a 32-year-old man taking 10 mg daily for just two weeks developed elevated liver markers. Ligandrol has also been shown to lower HDL cholesterol (the protective kind) at doses as low as 0.3 to 1.0 mg daily for three weeks.

Side effects, ingredient by ingredient Ligandrol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ligandrol.
  • The most serious interaction on file is rated Moderate.
  • For scale: 371 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist about any medications that stress the liver (hepatotoxic drugs) — ligandrol may add to that liver damage. If you take any prescription medications, use the interaction checker on this page to confirm your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Ligandrol is an unapproved research compound, not a legal supplement, and carries documented risks of liver injury. If you're considering this product, you must talk with your doctor first — not just about drug interactions, but about whether taking an investigational substance is appropriate for you.

This isn't a decision to make on your own.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about LGD4033, straight from the product label.

Brand Swoll Mafia
Barcode (UPC) 451290958920
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2019
DSLD ID 200143
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for LGD4033 by Swoll Mafia, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
451290958920
IngredientAmount% DV
Ligandrol15 mg--

Other ingredients: Creatine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Administer 3 capsules once daily. Do not exceed 1 serving within 24 hours.

Precautions

Do not exceed 1 serving within 24 hours. Warning: Do not exceed recommended dosage. Consult with a physician before use.

Keep out of reach from children.

Do not administer if test subject is at risk or has health issues involving heart, kidney, liver, stroke, difficult urinating, depression, anxiety or seizure disorder.

All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following product. All customers must be 18 years old to purchase. Under no circumstance shall seller be liable for consequential damages, whether purchases claim contract, negligence, strict liability or otherwise. In purchasing this product the purchaser agrees to the above

For experimental use only Not for human consumption

Formula

Ligandrol

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease or illness.

Seals/Symbols

Proudly made in the United States USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

LGD4033 by Swoll Mafia label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

LGD4033 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in LGD4033 by Swoll Mafia

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Ligandrol

Interacts with
370 drugs
15 mg per serving

Ligandrol (LGD-4033) is a synthetic selective androgen receptor modulator (SARM), not a natural herb or approved dietary supplement. It is not approve...

Ligandrol monograph & interactions

Other (inactive) ingredients: Creatine. These complete the product’s ingredient list but are not active constituents.

Interaction report

LGD4033 by Swoll Mafia Drug Interactions

Want to check YOUR meds against LGD4033?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
370Drugs
370 Moderate

Ingredients driving the most interactions

Ligandrol 370

Individual Drug Interactions

The ingredients in LGD4033 interact with 370 drugs. Click any drug to see the details.

1 of the 1 ingredient in LGD4033 interact with drugs. Each result below shows which ingredient is responsible. Ligandrol

Each ingredient & the kinds of drugs it affects

For each ingredient in LGD4033 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Ligandrol1 drug type · 370 drugs

Hepatotoxic Drugs

Theoretically, concomitant use might have additive hepatotoxic effects.
In case reports, patients were diagnosed with liver injury thought to be related to the use of products containing ligandrol.

Likelihood Possible Evidence D
Ligandrol full monograph & interactions
The maker

Brand information

Manufacturer and brand details for LGD4033, from the product label.

Swoll Mafia

See all Swoll Mafia products
Name
Swoll Mafia
Pharmacist Counseling Corner

LGD4033 by Swoll Mafia: Common Questions

Does LGD4033 by Swoll Mafia interact with any medications?
Yes. Based on its ingredients, LGD4033 has a known interaction with 370 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
LGD4033 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is ligandrol a legal supplement?
No. Ligandrol is an unapproved investigational drug, not a legal dietary supplement. The FDA does not permit it in over-the-counter products.
What does the evidence say about whether ligandrol builds muscle?
The reliable evidence we have does not establish that ligandrol works for athletic performance, muscle strength, or any other condition we can rate. That doesn't mean it has no effect — it means the studies available don't meet the standard for us to confirm one.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advises against it completely in pregnancy, and safety is unknown in breastfeeding; the drug may pass into breast milk. Talk with your doctor if you are planning pregnancy or nursing.
What are the side effects?
Case reports link ligandrol to liver injury — sometimes severe enough to show up as elevated liver markers within weeks of starting. It also lowers HDL cholesterol, the kind your heart needs. The FDA has issued warnings about liver toxicity tied to SARM-containing supplements.
Why do I need to check my medications before taking this?
Ligandrol can stress your liver, and if your medications already do that, the combined effect could seriously harm your liver. Your doctor or pharmacist can review your specific drugs against that risk.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if LGD4033 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

LGD4033 label
Go deeper

The Full Monographs Behind LGD4033’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ligandrol

Interacts with 370 drugs

Ligandrol (LGD-4033) is a synthetic selective androgen receptor modulator (SARM), not a natural herb or approved dietary supplement. It is not approved for human use, is banned in sports, an...

Read the full Ligandrol monograph →
Sources

Sources & How We Checked

LGD4033's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ligandrol 9 references
  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
  2. Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
  3. Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
  4. Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
  5. Barbara M, Dhingra S, Mindikoglu AL. Drug-induced liver injury associated with alpha bolic (RAD-140) and alpha elite (RAD-140 and LGD-4033). ACG Case Rep J 2020;7(6):e00409. PubMed
  6. Barbara M, Dhingra S, Mindikoglu AL. Ligandrol (LGD-4033)-Induced Liver Injury. ACG Case Rep J 2020;7(6):e00370. PubMed
  7. Koller T, Vrbova P, Meciarova I, et al. Liver injury associated with the use of selective androgen receptor modulators and post-cycle therapy: Two case reports and literature review. World J Clin Cases 2021;9(16):4062-4071. PubMed
  8. Flores JE, Chitturi S, Walker S. Drug-induced liver injury by selective androgenic receptor modulators. Hepatol Commun. 2020;4(3):450-452. PubMed
  9. Basaria S, Collins L, Dillon EL, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci 2013;68(1):87-95. PubMed

See these in context on the Ligandrol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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