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Dietary supplement

Legend Ingredients & Drug Interactions

by Olympus UK

Legend label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Legend against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Legend is a dietary supplement by Olympus UK with 1 active ingredient. Its ingredients are commonly taken for muscle building, athletic performance and strength, body recomposition.Based on those ingredients, 370 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are LGD-4033. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Legend by Olympus UK

Ask about any prescription or over-the-counter medication and we check it for interactions with Legend by Olympus UK — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Legend by Olympus UK

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Legend contains one active ingredient: ligandrol (LGD-4033), a selective androgen receptor modulator (SARM)—a type of investigational compound designed to affect muscle and bone in targeted ways. The product also contains inactive ingredients: rice flour, magnesium stearate, and gelatin (the capsule material).

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: muscle building and athletic performance.
  • We looked for evidence on: Athletic performance, Muscle strength, Muscular dystrophy, Sarcopenia, Cachexia, body composition — and 2 related terms.
  • The closest evidence on file: Ligandrol is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Ligandrol is rated "Insufficient Reliable Evidence To Rate" for Cachexia, Muscle strength, Muscular dystrophy, Sarcopenia.

The evidence for ligandrol's effectiveness is not established in the data we hold. Ratings for athletic performance, muscle strength, cachexia (severe muscle wasting), muscular dystrophy, and breast cancer all fall into insufficient reliable evidence—meaning there isn't enough rigorous research to say whether it works for any of these purposes.

The evidence, ingredient by ingredient Ligandrol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ligandrol carries serious safety concerns. The FDA has warned that supplements containing SARMs like this one have been linked to liver toxicity, and there are documented cases of liver injury in people who used ligandrol alone—including a case of significant liver damage after just 2 weeks at 10 mg daily.

Additionally, ligandrol has been shown to lower HDL cholesterol (the 'good' kind) even at small doses. Ligandrol is also an unapproved investigational drug, not a legal dietary supplement, and the safety data advises against use in pregnancy and lactation; there is concern it could harm a developing baby or pass into breast milk.

Side effects, ingredient by ingredient Ligandrol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ligandrol.
  • The most serious interaction on file is rated Moderate.
  • For scale: 371 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your doctor or pharmacist about any medications or supplements you're on that are processed by or can affect the liver. The most serious documented interaction is Moderate severity: ligandrol plus hepatotoxic drugs (liver-toxic medications) might compound liver damage.

Given the FDA warning and case reports of liver injury tied to ligandrol alone, any medication that stresses the liver deserves a careful review of the combination.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Ligandrol is an unapproved investigational compound with documented risks of liver injury and a warning from the FDA. The evidence for its effectiveness is insufficient, and its safety profile—especially combined with medications that stress the liver—is a genuine concern.

Talk with your doctor or pharmacist before considering this product; they can help you understand the known risks and whether it's appropriate for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Legend, straight from the product label.

Brand Olympus UK
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Dec 22, 2019
DSLD ID 209961
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Legend by Olympus UK, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
IngredientAmount% DV
LGD-40334 mg--

Other ingredients: Rice Flour, Magnesium Stearate, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Building SARM

Formula

Turning men into demigods

FDA Statement of Identity

Dietary Supplement

General Statements

45 Day supply

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Legend by Olympus UK label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Legend label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Legend by Olympus UK

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

LGD-4033

Interacts with
370 drugs
4 mg per serving

Ligandrol (LGD-4033) is a synthetic selective androgen receptor modulator (SARM), not a natural herb or approved dietary supplement. It is not approve...

LGD-4033 monograph & interactions

Other (inactive) ingredients: Rice Flour, Magnesium Stearate, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Legend by Olympus UK Drug Interactions

Want to check YOUR meds against Legend?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
370Drugs
370 Moderate

Ingredients driving the most interactions

LGD-4033 370

Individual Drug Interactions

The ingredients in Legend interact with 370 drugs. Click any drug to see the details.

1 of the 1 ingredient in Legend interact with drugs. Each result below shows which ingredient is responsible. LGD-4033

Each ingredient & the kinds of drugs it affects

For each ingredient in Legend with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

LGD-40331 drug type · 370 drugs

Hepatotoxic Drugs

Theoretically, concomitant use might have additive hepatotoxic effects.
In case reports, patients were diagnosed with liver injury thought to be related to the use of products containing ligandrol.

Likelihood Possible Evidence D
LGD-4033 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Legend, from the product label.

Olympus UK

See all Olympus UK products
Name
Olympus Labs UK
Pharmacist Counseling Corner

Legend by Olympus UK: Common Questions

Does Legend by Olympus UK interact with any medications?
Yes. Based on its ingredients, Legend has a known interaction with 370 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Legend contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is ligandrol a legal supplement?
No. Ligandrol (LGD-4033) is an unapproved investigational drug, not a legal dietary supplement. The FDA has warned about SARM-containing products like this one.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advises against ligandrol completely in pregnancy—there is concern it could harm a developing baby. Safety is also unknown in lactation, and the drug may pass into breast milk. Talk with your doctor or pharmacist about safe alternatives.
Has ligandrol caused liver injury in real people?
Yes. There are documented cases of liver injury linked to ligandrol use alone, and the FDA has specifically warned that SARM-containing supplements carry liver toxicity risk. One case involved significant liver damage after just 2 weeks of use.
Does ligandrol lower cholesterol?
It can. Even at small doses (0.3–1.0 mg daily), ligandrol has been shown to decrease HDL cholesterol—the kind that protects your heart.
Is there proof that ligandrol builds muscle or improves athletic performance?
The evidence isn't established in the data we hold. Ratings for muscle strength, athletic performance, and related conditions all fall into insufficient reliable evidence, so we can't say whether it works for these purposes.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Legend is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Legend label
Go deeper

The Full Monographs Behind Legend’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ligandrol

Interacts with 370 drugs

Ligandrol (LGD-4033) is a synthetic selective androgen receptor modulator (SARM), not a natural herb or approved dietary supplement. It is not approved for human use, is banned in sports, an...

Read the full Ligandrol monograph →
Sources

Sources & How We Checked

Legend's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ligandrol 9 references
  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
  2. Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
  3. Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
  4. Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
  5. Barbara M, Dhingra S, Mindikoglu AL. Drug-induced liver injury associated with alpha bolic (RAD-140) and alpha elite (RAD-140 and LGD-4033). ACG Case Rep J 2020;7(6):e00409. PubMed
  6. Barbara M, Dhingra S, Mindikoglu AL. Ligandrol (LGD-4033)-Induced Liver Injury. ACG Case Rep J 2020;7(6):e00370. PubMed
  7. Koller T, Vrbova P, Meciarova I, et al. Liver injury associated with the use of selective androgen receptor modulators and post-cycle therapy: Two case reports and literature review. World J Clin Cases 2021;9(16):4062-4071. PubMed
  8. Flores JE, Chitturi S, Walker S. Drug-induced liver injury by selective androgenic receptor modulators. Hepatol Commun. 2020;4(3):450-452. PubMed
  9. Basaria S, Collins L, Dillon EL, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci 2013;68(1):87-95. PubMed

See these in context on the Ligandrol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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