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Dietary supplement

SARM GW-501516 Ingredients & Drug Interactions

by DNA Anabolics

SARM GW-501516 label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SARM GW-501516 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

SARM GW-501516 is a dietary supplement by DNA Anabolics with 1 active ingredient. Its ingredients are commonly taken for muscle building, athletic performance and strength, body recomposition.Based on those ingredients, 370 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are LGD-4033. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against SARM GW-501516 by DNA Anabolics

Ask about any prescription or over-the-counter medication and we check it for interactions with SARM GW-501516 by DNA Anabolics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of SARM GW-501516 by DNA Anabolics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: ligandrol (LGD-4033), a selective androgen receptor modulator (SARM) — a synthetic compound designed to bind to androgen receptors in muscle and bone tissue. It is not an approved medication and is not a legal dietary supplement.

The inactive ingredients are rice flour, magnesium stearate, and gelatin (the capsule material).

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Ligandrol product and its label doesn't state a use — see Ligandrol's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence supporting ligandrol for athletic performance, muscle strength, cancer treatment, cachexia (severe muscle wasting), or muscular dystrophy is insufficient to rate. The product facts we hold do not show reliable data establishing whether it works for any of these purposes.

The evidence, ingredient by ingredient Ligandrol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ligandrol carries significant safety red flags. It is an unapproved investigational drug, not a legal dietary supplement, and case reports document liver injury linked to its use — some occurring after just 2 weeks at typical doses.

The FDA has issued warnings about SARM-containing supplements and hepatotoxicity. Additionally, at even low doses (0.3 to 1.0 mg daily), it has lowered HDL cholesterol (the protective kind) in trial participants.

The safety data advises against use during pregnancy because of the risk of harm to a developing baby. For breastfeeding, safety is unknown and the drug may pass into breast milk — avoid use completely.

If you are pregnant, planning to become pregnant, or breastfeeding, do not take this product.

Side effects, ingredient by ingredient Ligandrol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ligandrol.
  • The most serious interaction on file is rated Moderate.
  • For scale: 371 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any hepatotoxic drugs — medications or substances that can stress or injure the liver, such as certain steroids, long-term NSAIDs, or high-dose acetaminophen. The risk of additive liver damage is documented.

If you have any history of liver problems or elevated liver enzymes, do not use this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product contains an unapproved investigational drug with documented liver toxicity risks and no established evidence of benefit for any labeled use. It is not a legal dietary supplement.

If you are considering it for muscle or athletic goals, talk with your doctor first — there are safer, legal alternatives. Do not use if you are pregnant, breastfeeding, or have liver disease.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SARM GW-501516, straight from the product label.

Brand DNA Anabolics
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Sep 21, 2018
DSLD ID 181150
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SARM GW-501516 by DNA Anabolics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
IngredientAmount% DV
LGD-40333 mg--

Other ingredients: Rice Flour, Magnesium Stearate, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Disclaimer & Waiver of Liability The materials for sale are intended for laboratory and research use only. They are not for use as food additives, drugs, cosmetics, household chemicals or other inappropriate applications. You must be a minimum of 21 years of age or older to purchase this product. Not for human consumption

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

GMP Good Manufacturing Practice

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SARM GW-501516 by DNA Anabolics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SARM GW-501516 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SARM GW-501516 by DNA Anabolics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

LGD-4033

Interacts with
370 drugs
3 mg per serving

Ligandrol (LGD-4033) is a synthetic selective androgen receptor modulator (SARM), not a natural herb or approved dietary supplement. It is not approve...

LGD-4033 monograph & interactions

Other (inactive) ingredients: Rice Flour, Magnesium Stearate, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

SARM GW-501516 by DNA Anabolics Drug Interactions

Want to check YOUR meds against SARM GW-501516?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
370Drugs
370 Moderate

Ingredients driving the most interactions

LGD-4033 370

Individual Drug Interactions

The ingredients in SARM GW-501516 interact with 370 drugs. Click any drug to see the details.

1 of the 1 ingredient in SARM GW-501516 interact with drugs. Each result below shows which ingredient is responsible. LGD-4033

Each ingredient & the kinds of drugs it affects

For each ingredient in SARM GW-501516 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

LGD-40331 drug type · 370 drugs

Hepatotoxic Drugs

Theoretically, concomitant use might have additive hepatotoxic effects.
In case reports, patients were diagnosed with liver injury thought to be related to the use of products containing ligandrol.

Likelihood Possible Evidence D
LGD-4033 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SARM GW-501516, from the product label.

DNA Anabolics

See all DNA Anabolics products
Name
DNA Anabolics
Pharmacist Counseling Corner

SARM GW-501516 by DNA Anabolics: Common Questions

Does SARM GW-501516 by DNA Anabolics interact with any medications?
Yes. Based on its ingredients, SARM GW-501516 has a known interaction with 370 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SARM GW-501516 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is ligandrol FDA-approved?
No. Ligandrol is an unapproved investigational drug, not a legal dietary supplement. The FDA has issued warnings specifically about SARM-containing supplements and liver toxicity.
Can I take this if I'm pregnant or breastfeeding?
No. Ligandrol is possibly unsafe during pregnancy and poses a risk of harm to a developing baby. During breastfeeding, safety is unknown and the drug may pass into breast milk. Do not use this product if you are pregnant, planning to become pregnant, or breastfeeding.
Does ligandrol have any proven benefits?
The evidence we hold does not establish reliable proof that it works for athletic performance, muscle strength, cancer, muscle wasting, or muscular dystrophy.
What are the main safety concerns with this product?
Liver injury is the primary concern — case reports document liver damage in users, and the FDA has warned about hepatotoxicity linked to SARMs. It has also been shown to lower protective HDL cholesterol levels. Combined with other liver-stressing medications, the risk increases.
What are the inactive ingredients?
Rice flour, magnesium stearate, and gelatin (the capsule material).

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if SARM GW-501516 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SARM GW-501516 label
Go deeper

The Full Monographs Behind SARM GW-501516’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ligandrol

Interacts with 370 drugs

Ligandrol (LGD-4033) is a synthetic selective androgen receptor modulator (SARM), not a natural herb or approved dietary supplement. It is not approved for human use, is banned in sports, an...

Read the full Ligandrol monograph →
Sources

Sources & How We Checked

SARM GW-501516's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ligandrol 9 references
  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
  2. Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
  3. Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
  4. Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
  5. Barbara M, Dhingra S, Mindikoglu AL. Drug-induced liver injury associated with alpha bolic (RAD-140) and alpha elite (RAD-140 and LGD-4033). ACG Case Rep J 2020;7(6):e00409. PubMed
  6. Barbara M, Dhingra S, Mindikoglu AL. Ligandrol (LGD-4033)-Induced Liver Injury. ACG Case Rep J 2020;7(6):e00370. PubMed
  7. Koller T, Vrbova P, Meciarova I, et al. Liver injury associated with the use of selective androgen receptor modulators and post-cycle therapy: Two case reports and literature review. World J Clin Cases 2021;9(16):4062-4071. PubMed
  8. Flores JE, Chitturi S, Walker S. Drug-induced liver injury by selective androgenic receptor modulators. Hepatol Commun. 2020;4(3):450-452. PubMed
  9. Basaria S, Collins L, Dillon EL, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci 2013;68(1):87-95. PubMed

See these in context on the Ligandrol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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