Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Neanderthal Pro-Tren Stack Ingredients & Drug Interactions

by DNA Anabolics

Neanderthal Pro-Tren Stack label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Neanderthal Pro-Tren Stack against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Neanderthal Pro-Tren Stack is a dietary supplement by DNA Anabolics with 4 active ingredients. Its ingredients are commonly taken for muscle building (bodybuilding), strength gains, body recomposition.Based on those ingredients, 372 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 2a,3a-epithio-17a-methyl-5a-androstan-17b-ol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Neanderthal Pro-Tren Stack by DNA Anabolics

Ask about any prescription or over-the-counter medication and we check it for interactions with Neanderthal Pro-Tren Stack by DNA Anabolics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Neanderthal Pro-Tren Stack by DNA Anabolics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This 4-ingredient capsule contains two synthetic anabolic steroids — Hexadrone and Epistane — along with 6,7-dihydroxybergamottin and Estra-4,9,11-triene-3,17-dione. The product has no listed inactive ingredients beyond the capsule itself.

Both steroids are 17-alpha-alkylated androgens, a class designed to survive digestion and enter the bloodstream, but this structure is associated with liver damage. Neither ingredient is approved by the FDA, and Epistane is specifically banned for sale as a dietary supplement due to safety concerns.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: physique enhancement and muscle building.
  • We looked for evidence on: Athletic performance, Muscle strength, body composition, lean mass, strength gains.
  • The closest evidence on file: Epistane is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Epistane is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

We hold no reliable evidence that any of these ingredients work for athletic performance, muscle strength, sexual function, or weight loss. The facts show insufficient evidence to rate all of them — meaning studies either haven't been done, aren't strong enough, or don't exist in our data.

The evidence, ingredient by ingredient Hexadrone Epistane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both Hexadrone and Epistane are flagged as unapproved synthetic anabolic steroids with serious potential health risks and little safety data. Epistane is specifically noted as liver-toxic and structurally similar to a compound that caused severe liver injury (cholestasis, jaundice, and itching) in case reports — patients did not respond to standard treatment.

Both steroids must be avoided in pregnancy and while breastfeeding; they can harm a developing baby and pass to infants through breast milk.

Side effects, ingredient by ingredient Hexadrone Epistane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Epistane.
  • The most serious interaction on file is rated Moderate.
  • For scale: 373 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist about any medications that stress the liver (hepatotoxic drugs), as Epistane may have additive liver-damaging effects — a Moderate interaction. The product itself contains unapproved steroids with safety warnings, so any prescription medication warrants a conversation with your healthcare provider.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product contains unapproved, banned synthetic anabolic steroids with documented liver damage potential and no proven effectiveness in our data. If you're considering it, talk with your doctor or pharmacist first — they need to know about all your medications, especially any that affect your liver.

These steroids carry serious health risks that go well beyond the medication interactions we track.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Neanderthal Pro-Tren Stack, straight from the product label.

Brand DNA Anabolics
Barcode (UPC) 497966246953
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2015
DSLD ID 41560
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Neanderthal Pro-Tren Stack by DNA Anabolics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
497966246953
IngredientAmount% DV
6,7-Dihydroxybergamottin100 mg--
6-chloro-androst-4-ene-3-one-17b-ol100 mg--
Estra-4,9,11-triene-3,17-dione20 mg--
2a,3a-epithio-17a-methyl-5a-androstan-17b-ol20 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a physique-enhancing agent, take 1 capsule 2-3 times per day. Do not exceed 3 capsules in a 24 hour period. Always follow EPI with proper post cycle.

Precautions

Do not exceed 8 weeks of continuous use.

WARNING: Consult with a licensed physician before using this product. Do not take this product if you have prostate hypertophy, liver disease, kidney or heart disease. This product should not be taken by women.

This product should not be taken by women. In particular, those women who are pregnant, lactating or trying to become pregnant.

Do not take this product if you have been diagnosed with high cholesterol, prostate cancer, testicular cancer, breast cancer, or are under the age of 21.

Keep this product and all other supplements out of reach of children.

Must be 21 years of age to purchase this product.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT

General Statements

Made in the USA

PHYSIQUE ENHANCING AGENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Neanderthal Pro-Tren Stack by DNA Anabolics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Neanderthal Pro-Tren Stack label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Neanderthal Pro-Tren Stack by DNA Anabolics

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

6,7-Dihydroxybergamottin

100 mg per serving

6-chloro-androst-4-ene-3-one-17b-ol

No known
interactions
100 mg per serving

Hexadrone is a synthetic oral anabolic steroid (a 'prosteroid' or designer steroid) marketed in bodybuilding supplements, not a natural herb or vitami...

6-chloro-androst-4-ene-3-one-17b-ol monograph & interactions

Estra-4,9,11-triene-3,17-dione

20 mg per serving

2a,3a-epithio-17a-methyl-5a-androstan-17b-ol

Interacts with
372 drugs
20 mg per serving

Epistane is a synthetic anabolic steroid (a methylated 'designer steroid'), not a true dietary supplement or herb, even though it has been sold as a '...

2a,3a-epithio-17a-methyl-5a-androstan-17b-ol monograph & interactions
Interaction report

Neanderthal Pro-Tren Stack by DNA Anabolics Drug Interactions

Want to check YOUR meds against Neanderthal Pro-Tren Stack?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
372Drugs
372 Moderate

Ingredients driving the most interactions

2a,3a-epithio-17a-methyl-5a-androstan-17b-ol 372

Individual Drug Interactions

The ingredients in Neanderthal Pro-Tren Stack interact with 372 drugs. Click any drug to see the details.

1 of the 4 ingredients in Neanderthal Pro-Tren Stack interact with drugs. Each result below shows which ingredient is responsible. 2a,3a-epithio-17a-methyl-5a-androstan-17b-ol

Each ingredient & the kinds of drugs it affects

For each ingredient in Neanderthal Pro-Tren Stack with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

2a,3a-epithio-17a-methyl-5a-androstan-17b-ol1 drug type · 372 drugs

Hepatotoxic Drugs

Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Epistane is an anabolic androgenic steroid, and more specifically a 17-alpha-alkylated androgen. Therefore, there is concern that epistane has hepatotoxic effects. Also, epistane is structurally similar to epitiostanol, which has been associated with hepatotixicity in a case series of four patients.

Likelihood Possible Evidence D
2a,3a-epithio-17a-methyl-5a-androstan-17b-ol full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Neanderthal Pro-Tren Stack, from the product label.

DNA Anabolics

See all DNA Anabolics products
Name
DNA Anabolics
Web Address
www.thednaanabolics.com
Pharmacist Counseling Corner

Neanderthal Pro-Tren Stack by DNA Anabolics: Common Questions

Does Neanderthal Pro-Tren Stack by DNA Anabolics interact with any medications?
Yes. Based on its ingredients, Neanderthal Pro-Tren Stack has a known interaction with 372 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Neanderthal Pro-Tren Stack contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to use while pregnant or breastfeeding?
No. Both steroids in this product are rated possibly unsafe in pregnancy and lactation — they can harm a developing baby and pass to infants through breast milk. Do not use during pregnancy or while breastfeeding.
What does Epistane actually do?
We hold insufficient evidence to say it works for athletic performance, muscle strength, sexual function, or weight loss. Despite marketing claims, reliable studies proving its effectiveness are not in our data.
Why is Epistane banned?
Epistane is banned for sale as a dietary supplement because it's a liver-toxic anabolic steroid, not a safe supplement. It's structurally similar to a compound that caused severe, treatment-resistant liver injury in case reports.
What are the side effects?
Epistane specifically carries risk of liver damage — jaundice, itching, and bile backup in the liver — and patients in reported cases did not respond to standard treatment. Both steroids in this product carry serious health warnings.
Can I take this with blood pressure or cholesterol medication?
You need to talk with your doctor or pharmacist before combining this product with any prescription medication, especially ones affecting your liver. The steroids here carry documented liver risks and are unapproved.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Neanderthal Pro-Tren Stack is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Neanderthal Pro-Tren Stack label
Go deeper

The Full Monographs Behind Neanderthal Pro-Tren Stack’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hexadrone

Hexadrone is a synthetic oral anabolic steroid (a 'prosteroid' or designer steroid) marketed in bodybuilding supplements, not a natural herb or vitamin. It is not an approved drug, its safet...

Read the full Hexadrone monograph → Herb & supplement monograph

Epistane

Interacts with 372 drugs

Epistane is a synthetic anabolic steroid (a methylated 'designer steroid'), not a true dietary supplement or herb, even though it has been sold as a 'prohormone.' It is liver-toxic, can disr...

Read the full Epistane monograph →
Sources

Sources & How We Checked

Neanderthal Pro-Tren Stack's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hexadrone 1 reference
  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

See these in context on the Hexadrone monograph →

Epistane 3 references
  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
  2. Rahnema CD, Crosnoe LE, Kim ED. Designer steroids - over-the-counter supplements and their androgenic component: review of an increasing problem. Andrology. 2015;3(2):150-5. PubMed
  3. Díaz FC, Sáez-González E, Benlloch S, et al. Albumin dialysis with MARS for the treatment of anabolic steroid-induced cholestasis. Ann Hepatol. 2016;15(6):939-943.

See these in context on the Epistane monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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