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Dietary supplement

Andarine S4 Ingredients & Drug Interactions

by Cratus Labs

Andarine S4 label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Andarine S4 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Andarine S4 is a dietary supplement by Cratus Labs with 1 active ingredient. Its ingredients are commonly taken for muscle building, strength gains, fat loss / body recomposition.Based on those ingredients, 9 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are S4. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Andarine S4 by Cratus Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Andarine S4 by Cratus Labs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Andarine S4 by Cratus Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Andarine S4 contains one active ingredient: andarine (also called S-4), a selective androgen receptor modulator (a compound that binds to androgen receptors in the body). The capsule also holds inactive ingredients—rice flour, magnesium stearate, and gelatin—which serve as fillers and binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Andarine product and its label doesn't state a use — see Andarine's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We hold no effectiveness ratings for andarine in our data, so we cannot tell you whether this product works for any particular purpose based on established evidence.

The evidence, ingredient by ingredient Andarine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Andarine is an unapproved drug with unknown human safety and is not a legal supplement. The FDA has warned that selective androgen receptor modulators like this one could potentially increase the risk of heart attack and stroke.

No thorough safety evaluations of andarine in humans have been conducted, and liver toxicity is a potential concern. This product should be avoided during pregnancy—hormone-affecting drugs pose a risk to a developing fetus.

It is also unsafe and unstudied during breastfeeding and should be avoided if you are nursing.

Side effects, ingredient by ingredient Andarine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Andarine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 9 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any androgens or testosterone-replacement therapy, do not use this product without talking to your prescriber first. The combination may amplify androgenic side effects.

Run your exact medications through the checker below before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Andarine S4 is an unapproved, unregulated compound with unknown human safety. The FDA has flagged serious cardiovascular and liver risks.

If you're considering this product, talk to your pharmacist or doctor first—especially if you take any hormone medications, and definitely if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Andarine S4, straight from the product label.

Brand Cratus Labs
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Dec 22, 2019
DSLD ID 209864
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses No Claim
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Andarine S4 by Cratus Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
IngredientAmount% DV
S425 mg--

Other ingredients: Rice Flour, Magnesium Stearate, Gelatin

Tap any ingredient to jump to its full detail below.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Andarine S4 by Cratus Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Andarine S4 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Andarine S4 by Cratus Labs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

S4

Interacts with
9 drugs
25 mg per serving

Andarine (S-4) is a synthetic selective androgen receptor modulator (SARM) that is not approved by the FDA for human use and is banned in sports. It i...

S4 monograph & interactions

Other (inactive) ingredients: Rice Flour, Magnesium Stearate, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Andarine S4 by Cratus Labs Drug Interactions

Want to check YOUR meds against Andarine S4?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
9Drugs
9 Moderate

Ingredients driving the most interactions

S4 9

Individual Drug Interactions

The ingredients in Andarine S4 interact with 9 drugs. Click any drug to see the details.

1 of the 1 ingredient in Andarine S4 interact with drugs. Each result below shows which ingredient is responsible. S4

Each ingredient & the kinds of drugs it affects

For each ingredient in Andarine S4 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

S41 drug type · 9 drugs

Androgens

Due to its androgenic properties, Andarine (S-4) may theoretically interact with other androgenic drugs, potentially increasing the risk of side effects associated with androgenic activity (source: https://pubmed.ncbi.nlm.nih.gov/12604714/). These side effects can include masculinization, virilization, acne, hair loss, increased libido, aggression, mood changes, and liver toxicity.

Likelihood Possible Evidence C
S4 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Andarine S4, from the product label.

Cratus Labs

See all Cratus Labs products
Name
Cratus Labs
Pharmacist Counseling Corner

Andarine S4 by Cratus Labs: Common Questions

Does Andarine S4 by Cratus Labs interact with any medications?
Yes. Based on its ingredients, Andarine S4 has a known interaction with 9 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Andarine S4 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is andarine approved by the FDA?
No. Andarine is an unapproved drug and is not a legal supplement. The FDA has issued warnings about selective androgen receptor modulators like this one due to potential cardiovascular and liver risks.
Can I take this while pregnant or breastfeeding?
No. Andarine is unsafe during pregnancy because it affects hormones and may harm a developing fetus. It is also unstudied and unsafe during breastfeeding, so you should avoid it if you're nursing.
What are the main risks I should know about?
The FDA has warned that andarine could potentially increase the risk of heart attack and stroke. Liver toxicity is also a concern. No thorough safety testing in humans has been done, so the full range of risks is unknown.
Will this interact with testosterone replacement therapy?
Yes. Because andarine has androgenic properties, combining it with testosterone or other androgens may increase unwanted hormonal side effects like acne, hair loss, and aggression. Do not use this product if you take androgen therapy without talking to your doctor first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Andarine S4 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Andarine S4 label
Go deeper

The Full Monographs Behind Andarine S4’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Andarine

Interacts with 9 drugs

Andarine (S-4) is a synthetic selective androgen receptor modulator (SARM) that is not approved by the FDA for human use and is banned in sports. It is not a legal dietary supplement ingredi...

Read the full Andarine monograph →
Sources

Sources & How We Checked

Andarine S4's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Andarine 1 reference
  1. FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.

See these in context on the Andarine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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