Drug & supplement interaction

Hemp Agrimony + Ingenol Mebutate

Ingenol Mebutate brand name: Picato.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Hemp Agrimony and Ingenol Mebutate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Hemp Agrimony and Ingenol Mebutate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ingenol Mebutate and Hemp Agrimony in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hemp Agrimony safety at a glance

Hemp Agrimony overall Avoid It may contain liver-toxic pyrrolizidine alkaloids, so internal use is generally not recommended.
Pregnancy Likely Unsafe When used orally. Hemp agrimony preparations, containing hepatotoxic pyrrolizidine alkaloid (PA) constituents, might be teratogenic and hepatotoxic. There is in... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in hemp agrimony are excreted in milk. There is insufficient reliable information availab... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ingenol Mebutate and Hemp Agrimony? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ingenol Mebutate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ingenol Mebutate is filed under a single classification — topical drugs. Hemp Agrimony has documented interactions with 2 drug classes — the most serious being cytochrome p450 3a4 (cyp3a4) inducers (moderate) and hepatotoxic drugs (moderate) — and none of Ingenol Mebutate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Hemp Agrimony Does Interact With Other Medications

Hemp Agrimony has 438 moderate known drug interactions in our database — Ingenol Mebutate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 438 No known interaction 2,392 (incl. Ingenol Mebutate)
Taking anything else?

Check Another of Your Medications Against Hemp Agrimony

Covers the 2,830 medications we’ve checked against Hemp Agrimony. Pick one to open its full report.

What to actually watch for

What Hemp Agrimony Itself Has Been Linked To

This is not an interaction — nothing below involves Ingenol Mebutate. It is the side-effect record for Hemp Agrimony on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Hemp Agrimony, this list is the first place to look.

  • Diarrhea / Vomiting Additional detail

    “Orally, the major concern with hemp agrimony preparations is the hepatotoxic pyrrolizidine alkaloid (PA) content. Chronic exposure to other plants containing hepatotoxic PA constituents is associated with veno-occlusive disease. Subacute veno-occlusive disease causes vague symptoms with persistent liver enlargement.”

    Hemp Agrimony · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 12841. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
    2. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
    3. 4021. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
    4. 3484. Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Hemp Agrimony — expand a row for the licensed statement it rests on. We haven’t matched Ingenol Mebutate to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Ingenol Mebutate.

Special populations

Hemp Agrimony in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Hemp agrimony preparations, containing hepatotoxic pyrrolizidine alkaloid (PA) constituents, might be teratogenic and hepatotoxic. There is insufficient reliable information available about the safety of using hemp agrimony products that do not contain hepatotoxic PAs during pregnancy.

Lactation Likely Unsafe

When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in hemp agrimony are excreted in milk. There is insufficient reliable information available about the safety of using hemp agrimony products that do not contain hepatotoxic PAs during lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Ingenol Mebutate

This page covers Hemp Agrimony only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ingenol Mebutate page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Ingenol Mebutate page

“Ingenol mebutate (Picato) is a gel applied to the skin for actinic keratosis, the rough precancerous patches caused by sun damage, and it is deliberately harsh, producing redness, flaking, and stinging as part of how it works. The few supplement interactions on record are all skin-level ones.”

Reviewed by 2 · Jul 18, 2026

Open the Ingenol Mebutate interaction page

One more smart check

Taking Hemp Agrimony as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Hemp Agrimony, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hemp Agrimony. Even though Hemp Agrimony itself has no known interaction with Ingenol Mebutate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Hemp Agrimony and Ingenol Mebutate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hemp Agrimony
Top half

#390 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ingenol Mebutate
Steady interest

#2,738 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hemp Agrimony reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Hemp Agrimony and Ingenol Mebutate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hemp Agrimony

What is Hemp Agrimony?

Hemp Agrimony
  • Digestive complaints
  • Cold and flu symptoms
  • Respiratory conditions
  • Mild fever
  • Traditional 'tonic' or detox use

Hemp agrimony is a traditional European herb that has been used for digestion, colds, and as a general tonic, but there is very little reliable human research to support these uses. More importantly, the plant can contain pyrrolizidine alkaloids that may harm the liver, so most experts do not recommend taking it internally. Talk with your pharmacist or doctor before using any product that contains hemp agrimony.

Eupatorium cannabinum · Asteraceae · Aerial parts (leaves, flowers, stems) and roots · Tea, tincture, dried herb, liquid extract

An interaction check asks whether these two react with each other — it does not ask whether Hemp Agrimony is a good idea for someone in your situation. Here is what our Hemp Agrimony record says about it on its own.

Hemp Agrimony: dosing

There is no established safe or standardized dose for hemp agrimony. Because of concerns about liver-toxic compounds, most reliable sources do not recommend taking it internally at all.If a product containing hemp agrimony is available, do not assume any amount is proven safe. When possible, choose better-studied alternatives for whatever condition you are trying to treat.

From our Hemp Agrimony monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hemp Agrimony monograph & all interactions
Medication

About Ingenol Mebutate Topical

What Is Ingenol Mebutate Topical Used For?

Brand name: Picato

  • Ingenol mebutate gel is used to treat actinic keratosis (flat, scaly growths on the skin caused by too much sun exposure). Ingenol mebutate is in a class of medications called cytotoxic agents. It works by killing fast-growing cells such as the abnormal cells associated with actinic keratoses.

See full Ingenol Mebutate Topical drug information
Keep checking

Other Drugs & Hemp Agrimony

Browse every other medication we’ve checked against Hemp Agrimony — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
438Moderate
0Minor
2,391No known interaction
438 Moderate 2,391 No interaction
Moderate

438 interactions

Showing 60 of 438 moderate interactions — see all 438 on the Hemp Agrimony page.

No interaction 2,391 drugs checked — show the list

We also checked Hemp Agrimony against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,391 medications checked with no known interaction — see the full Hemp Agrimony list.

See the full Hemp Agrimony interactions page
See every supplement checked against Ingenol Mebutate, ranked by severity
Evidence & sources

Hemp Agrimony References

The 5 references that drive our Hemp Agrimony monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
  2. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  3. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  4. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  5. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hemp Agrimony and Ingenol Mebutate Together: Common Questions

Is it safe to take Hemp Agrimony with Ingenol Mebutate?
We do not list a known interaction between Hemp Agrimony and Ingenol Mebutate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Hemp Agrimony and Ingenol Mebutate combination checked?
Interactions in our licensed database are recorded against drug classes. Ingenol Mebutate is filed under 1 classification, and Hemp Agrimony has documented interactions with 2 drug classes — none of Ingenol Mebutate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Hemp Agrimony interact with any other medications?
Yes. Hemp Agrimony has 438 documented drug interactions in our database — Ingenol Mebutate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ingenol Mebutate interact with any supplements?
Yes. Ingenol Mebutate has documented interactions with 3 supplements in our database — Hemp Agrimony is not one of them. The Ingenol Mebutate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hemp Agrimony monograph Uses, safety profile, and every drug interaction in one place Ingenol Mebutate Topical drug information The full plain-English guide to this medication Ingenol Mebutate supplement interactions Every supplement checked against Ingenol Mebutate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ingenol Mebutate and Hemp Agrimony?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.