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Dietary supplement

Waterhemp 450 mg Ingredients & Drug Interactions

by TerraVita Premium Collection

Waterhemp 450 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Waterhemp 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Waterhemp 450 mg is a dietary supplement by TerraVita Premium Collection with 1 active ingredient. Its ingredients are commonly taken for digestive complaints, cold and flu symptoms, respiratory conditions.Based on those ingredients, 438 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Waterhemp. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Waterhemp 450 mg by TerraVita Premium Collection

Ask about any prescription or over-the-counter medication and we check it for interactions with Waterhemp 450 mg by TerraVita Premium Collection — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Waterhemp 450 mg by TerraVita Premium Collection

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: waterhemp (also called hemp agrimony) at 450 mg per capsule. The capsules also contain gelatin and water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Hemp Agrimony product and its label doesn't state a use — see Hemp Agrimony's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We hold no effectiveness ratings for waterhemp in our data, so we can't tell you what the evidence shows about how well it works for any condition.

The evidence, ingredient by ingredient Hemp Agrimony

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Here's the important part: hemp agrimony contains liver-toxic compounds called pyrrolizidine alkaloids. The data advises against internal use because of this concern.

Long-term exposure to plants with these alkaloids can cause a serious liver condition called veno-occlusive disease, which causes enlarged liver, abdominal pain, vomiting, diarrhea, and fluid buildup. Symptoms can develop over days to weeks.

Do not use this product during pregnancy—it's rated likely unsafe because of liver toxicity risk and insufficient safety data. Do not use while breastfeeding for the same reasons.

Side effects, ingredient by ingredient Hemp Agrimony

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hemp Agrimony.
  • The most serious interaction on file is rated Moderate.
  • For scale: 439 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check any medications that affect your liver (like acetaminophen, amiodarone, carbamazepine, isoniazid, or methotrexate) or that induce CYP3A4 enzymes (like phenobarbital, phenytoin, rifampin, or rifabutin) with your pharmacist. These are documented Moderate-severity interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Given the liver-toxic alkaloid content, this product carries real safety concerns for oral use. If you're considering it, talk with your pharmacist or doctor first—especially if you take any medications that affect your liver or how your body processes drugs.

Pregnant people and those breastfeeding should not use it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Waterhemp 450 mg, straight from the product label.

Brand TerraVita Premium Collection
Barcode (UPC) 064435126384
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 286624
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Waterhemp 450 mg by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
064435126384
IngredientAmount% DV
Waterhemp450 mg--

Other ingredients: Gelatin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Brand IP Statement(s)

Copyright 2005 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Suggested/Recommended/Usage/Directions

Directions Take 1 capsule, 3 times daily, with meals.

General Statements

TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.

Please recycle!

FDA Disclaimer Statement

Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Waterhemp 450 mg by TerraVita Premium Collection label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Waterhemp 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Waterhemp 450 mg by TerraVita Premium Collection

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Waterhemp

Interacts with
438 drugs
450 mg per serving

Hemp agrimony is a traditional European herb that has been used for digestion, colds, and as a general tonic, but there is very little reliable human...

Waterhemp monograph & interactions

Other (inactive) ingredients: Gelatin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Waterhemp 450 mg by TerraVita Premium Collection Drug Interactions

Want to check YOUR meds against Waterhemp 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
438Drugs
438 Moderate

Ingredients driving the most interactions

Waterhemp 438

Individual Drug Interactions

The ingredients in Waterhemp 450 mg interact with 438 drugs. Click any drug to see the details.

1 of the 1 ingredient in Waterhemp 450 mg interact with drugs. Each result below shows which ingredient is responsible. Waterhemp

Each ingredient & the kinds of drugs it affects

For each ingredient in Waterhemp 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Waterhemp2 drug types · 438 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA) which are substrates of cytochrome P450 3A4 (CYP3A4). Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites. Some drugs that induce CYP3A4 include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA). Theoretically, using hemp agrimony with hepatotoxic drugs might have additive adverse effects on the liver. Some drugs that can adversely affect the liver include acetaminophen (Tylenol and others), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporanox), erythromycin (Erythrocin, Ilosone, others), phenytoin (Dilantin), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), and many others.

Likelihood Possible Evidence D
Waterhemp full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Waterhemp 450 mg, from the product label.

TerraVita Premium Collection

See all TerraVita Premium Collection products
Name
TerraVita Fine Whole Herbs
City
Brampton
State
Ontario
Pharmacist Counseling Corner

Waterhemp 450 mg by TerraVita Premium Collection: Common Questions

Does Waterhemp 450 mg by TerraVita Premium Collection interact with any medications?
Yes. Based on its ingredients, Waterhemp 450 mg has a known interaction with 438 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Waterhemp 450 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
No. The safety data rates it likely unsafe in pregnancy because of liver toxicity risk and lack of safety information. Do not use it if you're pregnant or planning to become pregnant.
Is it safe to breastfeed while taking this?
No. It's rated likely unsafe while breastfeeding because of possible toxic compounds and no safety data. If you're nursing, avoid this product.
What are the side effects I should watch for?
The main concern is liver damage from its pyrrolizidine alkaloid content. Long-term use can cause veno-occlusive disease, which starts with a persistently enlarged liver and can progress to abdominal pain, vomiting, diarrhea, and fluid buildup in the abdomen. If you notice any of these symptoms, stop and contact your doctor right away.
Why does this product come with a warning about the liver?
Hemp agrimony naturally contains compounds that can harm the liver, especially with repeated or long-term use. This is why internal use is generally not recommended.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Waterhemp 450 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Waterhemp 450 mg label
Go deeper

The Full Monographs Behind Waterhemp 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hemp Agrimony

Interacts with 438 drugs

Hemp agrimony is a traditional European herb that has been used for digestion, colds, and as a general tonic, but there is very little reliable human research to support these uses. More imp...

Read the full Hemp Agrimony monograph →
Sources

Sources & How We Checked

Waterhemp 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hemp Agrimony 5 references
  1. Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
  2. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  3. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  4. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  5. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed

See these in context on the Hemp Agrimony monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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