Caraway - Isoniazid, Pyrazinamide, Rifampin Interaction
Herbal: Caraway
Also Known As: Carum carvi, Alcaravea, Anis Canadien, Anis des Prés, Anis des Vosges, Apium Carvi, Carraway, Carvi, Carvi Commun, Carvi Fructus, Cumin des Montagnes, Cumin des Prés, Faux Anis, Haravi, Jeera, Jira, Kala Jira, Karwiya, Krishan Jeeraka, Krishnajiraka, Kummel, Kummich, Roman Cum
Drug: Isoniazid, Pyrazinamide, Rifampin
Brand names:
Rifater
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Isoniazid, Pyrazinamide, Rifampin is classified as belonging to the following category: Isoniazid
Theoretically, caraway might increase the effects and adverse effects of isoniazid.
Animal research suggests that a specific fraction of caraway seed extract (CC-1a) can increase plasma levels of isoniazid when administered concomitantly. This interaction has not been reported in humans.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Sachin BS, Monica P, Sharma SC, et al. Pharmacokinetic interaction of some antitubercular drugs with caraway: implications in the enhancement of drug bioavailability. Hum Exp Toxicol. 2009;28(4):175-84.
Interaction Details
Isoniazid, Pyrazinamide, Rifampin is classified as belonging to the following category: Rifampin (Rifadin)
Theoretically, caraway might increase the effects and adverse effects of rifampin.
Animal research suggests that a specific fraction of caraway seed extract (CC-1a) can increase plasma levels of rifampin when administered concomitantly. This interaction has not been reported in humans.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Sachin BS, Monica P, Sharma SC, et al. Pharmacokinetic interaction of some antitubercular drugs with caraway: implications in the enhancement of drug bioavailability. Hum Exp Toxicol. 2009;28(4):175-84.
Interaction Details
Isoniazid, Pyrazinamide, Rifampin is classified as belonging to the following category: Pyrazinamide
Theoretically, caraway might increase the effects and adverse effects of pyrazinamide.
Animal research suggests that a specific fraction of caraway seed extract (CC-1a) can increase plasma levels of pyrazinamide when administered concomitantly. This interaction has not been reported in humans.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Sachin BS, Monica P, Sharma SC, et al. Pharmacokinetic interaction of some antitubercular drugs with caraway: implications in the enhancement of drug bioavailability. Hum Exp Toxicol. 2009;28(4):175-84.
Caraway Overview
Caraway is an herb native to Asia, Africa, and Europe. The seeds, fruit, and oil are used in cooking and for medicinal purposes. Its seeds have a pungent, anise-like flavor and aroma. In regard to its medical use, it has been historically used to increase breast milk production, and to treat a variety of conditions such as gastrointestinal issues, asthma, amenorrhea, and obesity, to name a few.
Caraway - More Interactions
Caraway interacts with 410 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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