Drug & supplement interaction

Hydrazine Sulfate + Docetaxel

Docetaxel brand name: Taxotere.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Hydrazine Sulfate and Docetaxel in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Hydrazine Sulfate and Docetaxel

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Docetaxel and Hydrazine Sulfate in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hydrazine Sulfate safety at a glance

Hydrazine Sulfate overall Avoid Rigorous trials showed no benefit and it can cause serious harm.
Pregnancy Possibly Unsafe When used orally. Hydrazine sulfate has been linked to cases of significant adverse effects including hepatotoxicity, encephalopathy, and death. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. Hydrazine sulfate has been linked to cases of significant adverse effects including hepatotoxicity, encephalopathy, and death. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Docetaxel and Hydrazine Sulfate? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Docetaxel

Interactions in our licensed database are recorded against drug classes, not just single drug names. Docetaxel is filed under 2 classifications — including cytochrome p450 3a4 (cyp3a4) substrates. Hydrazine Sulfate has documented interactions with 3 drug classes — the most serious being antidiabetes drugs (moderate), isoniazid (moderate) and monoamine oxidase inhibitors (maois) (moderate) — and none of Docetaxel’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Hydrazine Sulfate Does Interact With Other Medications

Hydrazine Sulfate has 98 moderate known drug interactions in our database — Docetaxel isn’t one of them. If you take anything else, check it against the full list below.

Moderate 98 No known interaction 2,732 (incl. Docetaxel)
Taking anything else?

Check Another of Your Medications Against Hydrazine Sulfate

Covers the 2,830 medications we’ve checked against Hydrazine Sulfate. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Hydrazine Sulfate and Docetaxel May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Numbness or tingling Additional detail

    Hydrazine Sulfate

    “Orally, hydrazine sulfate has been reported to cause paresthesia in the upper and lower extremities, tremors, lethargy/somnolence, confusion, convulsions, depression, headache, palpebral tic, slurred speech, hiccup, and vertigo.”

    Hydrazine Sulfate · Natural Medicines adverse-effect record, reported in cluster headache.

    6 sources cited
    1. 11767. Ochoa M Jr, Wittes RE, Krakoff IH. Trial of hydrazine sulfate (NSC-150014) in patients with cancer. Cancer Chemother Rep 1975;59:1151-4.
    2. 55782. Laszlo, J., Durant, J., and Loeb, V. Clinical pharmacologic study of 1-acetyl-2-picolinoyl hydrazine (NSC- 68626). Cancer Chemother Rep 1969;53(2):131-134.
    3. 55785. Reid, F. J. Hydrazine poisoning. Br Med J 11-20-1965;5472:1246.
    4. 55769. Wiernikowski, A. and Langer, D. [Acute poisoning with orally ingested hydrazine hydrate]. Polski Tygodnik Lekarski 7-21-1975;30(29):1231-1232.
    5. 55796. Filov, V. A., Gershanovich, M. L., Danova, L. A., and Ivin, B. A. Experience of the treatment with Sehydrin (Hydrazine Sulfate, HS) in the advanced cancer patients. Invest New Drugs 1995;13(1):89-97. PubMed
    6. 55764. Gershanovich, M. L., Danova, L. A., Kondratyev, V. B., Malyugina, L. L., Stukov, A. N., Seitz, J. F., and Filov, V. A. Clinical data on the antitumor activity of hydrazine sulfate. Cancer Treat.Rep. 1976;60(7):933-935.

    Docetaxel

    Listed in the ADVERSE REACTIONS section of the FDA label for Docetaxel. Read the label on DailyMed ›

  • Reduced appetite / Constipation / Diarrhea Additional detail

    Hydrazine Sulfate

    “Orally, hydrazine sulfate has been reported to cause nausea and vomiting in numerous clinical studies. It has also been reported to cause anorexia, pyrosis, diarrhea, constipation, distorted taste, and hunger.”

    Hydrazine Sulfate · Natural Medicines adverse-effect record, reported in anorexia.

    6 sources cited
    1. 55796. Filov, V. A., Gershanovich, M. L., Danova, L. A., and Ivin, B. A. Experience of the treatment with Sehydrin (Hydrazine Sulfate, HS) in the advanced cancer patients. Invest New Drugs 1995;13(1):89-97. PubMed
    2. 8004. Chlebowski RT, Bulcavage L, Grosvenor M, et al. Hydrazine sulfate in cancer patients with weight loss. A placebo-controlled clinical experience. Cancer 1987;59:406-10. PubMed
    3. 8005. Kaegi E. Unconventional therapies for cancer: 4. Hydrazine sulfate. Task Force on Alternative Therapies of the Canadian Breast Cancer Research Initiative. CMAJ 1998;158:1327-30.
    4. 55764. Gershanovich, M. L., Danova, L. A., Kondratyev, V. B., Malyugina, L. L., Stukov, A. N., Seitz, J. F., and Filov, V. A. Clinical data on the antitumor activity of hydrazine sulfate. Cancer Treat.Rep. 1976;60(7):933-935.
    5. 10385. Gershanovich ML, Danova LA, Ivin BA, Filov VA. Results of clinical study antitumor action of hydrazine sulfate. Nutr Cancer 1981;3:7-12..
    6. 11767. Ochoa M Jr, Wittes RE, Krakoff IH. Trial of hydrazine sulfate (NSC-150014) in patients with cancer. Cancer Chemother Rep 1975;59:1151-4.

    Docetaxel

    Listed in the ADVERSE REACTIONS section of the FDA label for Docetaxel. Read the label on DailyMed ›

  • Tiredness Additional detail

    Hydrazine Sulfate

    “In one case report, a 55-year-old male with sinus carcinoma developed hepatorenal failure after self-treating with hydrazine sulfate 180 mg daily for approximately four months. Two weeks after discontinuing hydrazine sulfate, the patient presented to the emergency room with rash, pruritus, progressive malaise, and jaundice.”

    Hydrazine Sulfate · Natural Medicines adverse-effect record, reported in hepatic encephalopathy.

    1 source cited
    1. 10384. Hainer MI, Tsai N, Komura ST, Chiu CL. Fatal hepatorenal failure associated with hydrazine sulfate. Ann Intern Med 2000;133:877-80. PubMed

    Docetaxel

    Listed in the ADVERSE REACTIONS section of the FDA label for Docetaxel. Read the label on DailyMed ›

  • Vomiting / Nausea Additional detail

    Hydrazine Sulfate

    “Hydrazine sulfate is generally considered unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity.

    Most Common Adverse Effects:

    Orally: Blurred vision, confusion, dizziness, nausea, vomiting.

    Serious Adverse Effects (Rare):

    Orally: Encephalopathy, hepatorenal failure.”

    Hydrazine Sulfate · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    Docetaxel

    Listed in the ADVERSE REACTIONS section of the FDA label for Docetaxel. Read the label on DailyMed ›

Reported for Hydrazine Sulfate but not commonly for Docetaxel: blurred vision, kidney problems, low blood sugar and seizures.

Effects for Docetaxel come from the ADVERSE REACTIONS section of its FDA label; effects for Hydrazine Sulfate come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Hydrazine Sulfate in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. Hydrazine sulfate has been linked to cases of significant adverse effects including hepatotoxicity, encephalopathy, and death.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Docetaxel Is Prescribed For, and What Hydrazine Sulfate Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Docetaxel is a prescription medicine with approved uses on its FDA label. Hydrazine Sulfate is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Docetaxel is prescribed for: Docetaxel Injection is used to treat a number of serious cancers. Beizray (docetaxel injection) is approved as a single agent for locally advanced or metastatic breast cancer after prior chemotherapy has stopped working, and in combination with doxorubicin and cyclophosphamide as adjuvant (after-surgery) treatment for operable node-positive breast cancer. It is also used as a single agent for locally advanced or metastatic non-small cell lung cancer (NSCLC) after platinum-based chemotherapy has failed, and with cisplatin for chemotherapy-naive advanced NSCLC. Beizray is used with prednisone for metastatic castration-resistant prostate cancer.

Read the rest of what Docetaxel is prescribed for

It is also used with cisplatin and fluorouracil for advanced gastric adenocarcinoma (including gastroesophageal junction cancer) in patients who have not received prior chemotherapy for advanced disease, and for induction treatment of locally advanced squamous cell carcinoma of the head and neck (SCCHN).

Hydrazine Sulfate has been studied for:

  • Lung cancer studied, not established Hydrazine Sulfate has been studied for this. Natural Medicines rates the evidence: Likely Ineffective Read what the research shows

    Hydrazine Sulfate for lung cancer

    Taking hydrazine sulfate as an adjunct to chemotherapy is not beneficial for treating non-small cell lung cancer (NSCLC) in most patients.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Docetaxel on your own; if you are taking Hydrazine Sulfate for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Docetaxel

This page covers Hydrazine Sulfate only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Docetaxel page lists 121 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 87 moderate · 32 minor.

From our pharmacist’s overview on the Docetaxel page

“Grapefruit is the first thing I would take off the menu during docetaxel (Taxotere) chemotherapy. It blocks CYP3A4, the liver enzyme that clears docetaxel, and higher levels of a chemotherapy drug mean harsher side effects, not better results.”

Reviewed by 2 · Jul 18, 2026

Open the Docetaxel interaction page

How much people look this up

Where Hydrazine Sulfate and Docetaxel Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hydrazine Sulfate
Steady interest

#1,172 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Docetaxel
Top half

#849 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hydrazine Sulfate reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Hydrazine Sulfate and Docetaxel records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hydrazine Sulfate

What is Hydrazine Sulfate?

  • Cancer-related weight loss (cachexia)
  • Cancer treatment (unproven)
  • Appetite stimulation
  • Improving quality of life in advanced illness

Hydrazine sulfate is a synthetic industrial chemical that was promoted as an alternative cancer treatment, but well-designed clinical trials found it does not help people with cancer live longer or feel better. It carries real risks, including serious nerve and liver toxicity, and is not approved or recommended for any medical use. Talk with your doctor or pharmacist before considering it.

Not applicable (synthetic industrial chemical) · Capsules, tablets, oral solution, and injectable forms (not legally available as a supplement in the U.S.)

An interaction check asks whether these two react with each other — it does not ask whether Hydrazine Sulfate is a good idea for someone in your situation. Here is what our Hydrazine Sulfate record says about it on its own.

Hydrazine Sulfate: dosing

There is no safe or recommended dose of hydrazine sulfate, and it is not approved for medical use. Because it is not a legitimate supplement, no standardized, evidence-based dosing exists.We do not recommend taking it at all.

From our Hydrazine Sulfate monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hydrazine Sulfate monograph & all interactions
Medication

About Docetaxel Injection

What Is Docetaxel Injection Used For?

Brand name: Taxotere

Docetaxel Injection is used to treat a number of serious cancers. Beizray (docetaxel injection) is approved as a single agent for locally advanced or metastatic breast cancer after prior chemotherapy has stopped working, and in combination with doxorubicin and cyclophosphamide as adjuvant (after-surgery) treatment for operable node-positive breast cancer. It is also used as a single agent for locally advanced or metastatic non-small cell lung cancer (NSCLC) after platinum-based chemotherapy has failed, and with cisplatin for chemotherapy-naive advanced NSCLC.

Beizray is used with prednisone for metastatic castration-resistant prostate cancer. It is also used with cisplatin and fluorouracil for advanced gastric adenocarcinoma (including gastroesophageal junction cancer) in patients who have not received prior chemotherapy for advanced disease, and for induction treatment of locally advanced squamous cell carcinoma of the head and neck (SCCHN).

Most-Reported Side Effects for Docetaxel

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Alopecia 16,970 reports
Madarosis 6,717 reports
Hair texture abnormal 5,993 reports
Hair colour changes 5,874 reports
Hair disorder 5,625 reports
See full Docetaxel Injection drug information
Keep checking

Other Drugs & Hydrazine Sulfate

Browse every other medication we’ve checked against Hydrazine Sulfate — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
98Moderate
0Minor
2,731No known interaction
98 Moderate 2,731 No interaction
Moderate

98 interactions

Showing 60 of 98 moderate interactions — see all 98 on the Hydrazine Sulfate page.

No interaction 2,731 drugs checked — show the list

We also checked Hydrazine Sulfate against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,731 medications checked with no known interaction — see the full Hydrazine Sulfate list.

See the full Hydrazine Sulfate interactions page
See every supplement checked against Docetaxel, ranked by severity
Evidence & sources

Hydrazine Sulfate References

The 18 references that drive our Hydrazine Sulfate monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Chlebowski RT, Bulcavage L, Grosvenor M, et al. Hydrazine sulfate in cancer patients with weight loss. A placebo-controlled clinical experience. Cancer 1987;59:406-10. PubMed
  2. Kaegi E. Unconventional therapies for cancer: 4. Hydrazine sulfate. Task Force on Alternative Therapies of the Canadian Breast Cancer Research Initiative. CMAJ 1998;158:1327-30.
  3. Hainer MI, Tsai N, Komura ST, Chiu CL. Fatal hepatorenal failure associated with hydrazine sulfate. Ann Intern Med 2000;133:877-80. PubMed
  4. Gershanovich ML, Danova LA, Ivin BA, Filov VA. Results of clinical study antitumor action of hydrazine sulfate. Nutr Cancer 1981;3:7-12..
  5. Ochoa M Jr, Wittes RE, Krakoff IH. Trial of hydrazine sulfate (NSC-150014) in patients with cancer. Cancer Chemother Rep 1975;59:1151-4.
  6. Sarich TC, Adams SP, Petricca G, Wright JM. Inhibition of isoniazid-induced hepatotoxicity in rabbits by pretreatment with an amidase inhibitor. J Pharmacol Exp Ther 1999;289:695-702. DOI
  7. Black M, Hussain H. Hydrazine, cancer, the Internet, isoniazid, and the liver. Ann Intern Med 2000;133:911-3. PubMed
  8. Gershanovich, M. L., Danova, L. A., Kondratyev, V. B., Malyugina, L. L., Stukov, A. N., Seitz, J. F., and Filov, V. A. Clinical data on the antitumor activity of hydrazine sulfate. Cancer Treat.Rep. 1976;60(7):933-935.
  9. Nagappan, R. and Riddell, T. Pyridoxine therapy in a patient with severe hydrazine sulfate toxicity. Crit Care Med. 2000;28(6):2116-2118. PubMed
  10. Wiernikowski, A. and Langer, D. [Acute poisoning with orally ingested hydrazine hydrate]. Polski Tygodnik Lekarski 7-21-1975;30(29):1231-1232.
  11. Gold, J. Use of hydrazine sulfate in terminal and preterminal cancer patients: results of investigational new drug (IND) study in 84 evaluable patients. Oncology 1975;32(1):1-10. PubMed
  12. Spremulli, E., Wampler, G. L., and Regelson, W. Clinical study of hydrazine sulfate in advanced cancer patients. Cancer Chemother.Pharmacol. 1979;3(2):121-124. PubMed
  13. Laszlo, J., Durant, J., and Loeb, V. Clinical pharmacologic study of 1-acetyl-2-picolinoyl hydrazine (NSC- 68626). Cancer Chemother Rep 1969;53(2):131-134.
  14. Freese, E., Sklarow, S., and Freese, E. B. DNA damage caused by antidepressant hydrazines and related drugs. Mutat.Res 1968;5(3):343-348. PubMed
  15. Reid, F. J. Hydrazine poisoning. Br Med J 11-20-1965;5472:1246.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hydrazine Sulfate and Docetaxel Together: Common Questions

Is it safe to take Hydrazine Sulfate with Docetaxel?
We do not list a known interaction between Hydrazine Sulfate and Docetaxel. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Hydrazine Sulfate and Docetaxel have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Hydrazine Sulfate and Docetaxel used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Hydrazine Sulfate in each. That is a conversation for your prescriber, especially if Docetaxel is being adjusted to a target.
How was the Hydrazine Sulfate and Docetaxel combination checked?
Interactions in our licensed database are recorded against drug classes. Docetaxel is filed under 2 classifications, and Hydrazine Sulfate has documented interactions with 3 drug classes — none of Docetaxel's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Hydrazine Sulfate interact with any other medications?
Yes. Hydrazine Sulfate has 98 documented drug interactions in our database — Docetaxel is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Docetaxel interact with any supplements?
Yes. Docetaxel has documented interactions with 121 supplements in our database — Hydrazine Sulfate is not one of them. The Docetaxel interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hydrazine Sulfate monograph Uses, safety profile, and every drug interaction in one place Docetaxel Injection drug information The full plain-English guide to this medication Docetaxel supplement interactions Every supplement checked against Docetaxel, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 18 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Docetaxel and Hydrazine Sulfate?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.