American Mistletoe - Testosterone Undecanoate Interaction
Herbal: American Mistletoe
Also Known As: Phoradendron leucarpum, Eastern Mistletoe
Drug: Testosterone Undecanoate
Brand names:
Andriol, Aveed, Jatenzo, Kyzatrex
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 13, 2024
Interaction Details
There were no interactions found between Testosterone Undecanoate and American Mistletoe. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
American Mistletoe Overview
American mistletoe, scientifically known as Phoradendron leucarpum, is a parasitic plant found in the eastern United States and Mexico. It grows on hardwood trees like oaks and hickories. Although it has been used in traditional Native American medicine, there isn't strong scientific evidence for its effectiveness.
American mistletoe contains phoratoxin, a compound that can be toxic. This toxin induces smooth muscle contraction, leading to increased uterine and intestinal motility, which can result in gastrointestinal symptoms. Additionally, it can cause vasoconstriction, leading to changes in blood pressure and heart rate, similar to the effects of cardiotoxins found in cobra venom.
Most case reports documenting ingestion suggest that eating up to 20 berries or 5 leaves is unlikely to cause serious harm, but there are reports of fatalities from cardiovascular collapse after drinking tea made from an unspecified amount of berries.
It's important to note that American mistletoe is different from European mistletoe, which is more commonly used in dietary supplements.
Testosterone Undecanoate Overview
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Testosterone cypionate (Depo-Testosterone), testosterone enanthate (Xyosted, available generically), testosterone undecanoate (Aveed), and testosterone pellet (Testopel) are forms of testosterone injection used to treat symptoms of low testosterone in men who have hypogonadism (a condition in which the body does not produce enough natural testosterone). Testosterone is used only for men with low testosterone levels caused by certain medical conditions, including disorders of the testicles, pituitary gland (a small gland in the brain), or hypothalamus (a part of the brain) that cause hypogonadism. Your doctor will order certain lab tests to check your testosterone levels to see if they are low before you begin to use testosterone injection. Testosterone enanthate (available generically) and testosterone pellet (Testopel) are also used to stimulate puberty in males with delayed puberty. Testosterone enanthate (available generically) injection may be used in certain women with a type of breast cancer called mammary cancer that has spread to other parts of the body. Testosterone should not be used to treat the symptoms of low testosterone in men who have low testosterone due to aging ('age related hypogonadism'). Testosterone is in a class of medications called androgenic hormones. Testosterone is a hormone produced by the body that contributes to the growth, development, and functioning of the male sexual organs and typical male characteristics. Testosterone injection works by supplying synthetic testosterone to replace the testosterone that is normally produced naturally in the body. When used to treat breast cancer, testosterone works by stopping the release of estrogen.
American Mistletoe - More Interactions
American Mistletoe interacts with 187 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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