American Pawpaw - Symmetrel (Amantadine) Interaction
Herbal: American Pawpaw
Also Known As: Asimina triloba, Asimina, Asiminier, Banango, Custard Apple, Dog-Banana, Hoosier Banana, Indiana Banana, Kentucky Banana, Ozark Banana, Papaye American, Pawpaw, Paw, Poor Man's Banana
Drug: Amantadine
Brand names:
Symmetrel, Gocovri, Osmolex ER
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 13, 2024
Interaction Details
There were no interactions found between Amantadine and American Pawpaw. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
American Pawpaw Overview
Asimina triloba, also known as pawpaw, is a deciduous tree native to North America. It is recognized for its large, tropical-like leaves and distinctive oblong fruits resembling a mix of mangoes and bananas. Typically found in moist, fertile soils in forest understories or along riverbanks, the pawpaw tree is of medicinal interest due to its potential anticancer properties attributed to its acetogenin content, including annonacin. Annonacin has shown cytotoxic effects against cancer cells, particularly in laboratory studies, by disrupting mitochondrial function, leading to cell death. Other mechanisms are likely involved as well. While promising, more research is needed to fully understand its mechanisms and therapeutic potential. Other constituents of American pawpaw include epigallocatechin, epicatechin, and p-coumaric acid.
Amantadine Overview
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Amantadine is used to treat the symptoms of Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) and other similar conditions. It is also used to control movement problems that are a side effect of certain medications used to treat Parkinson's disease. Amantadine extended-release capsules (Gocovri) are used along with the combination of levodopa and carbidopa (Rytary, Sinemet) to treat ''off'' episodes (times of difficulty moving, walking, and speaking that may happen when other medications wear off) in people with Parkinson's disease. It also is used to prevent symptoms of influenza A virus infection and for treatment of respiratory infections caused by influenza A virus. Amantadine is in a class of medications called adamantanes. It is thought to work to control movement problems by increasing the amount of dopamine in certain parts of the body. It works against influenza A virus by stopping the spread of the virus in the body.
American Pawpaw - More Interactions
American Pawpaw interacts with 25 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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