Androstenedione - Ethinyl Estradiol, Norethindrone Interaction
Herbal: Androstenedione
Drug: Ethinyl Estradiol, Norethindrone
Brand names:
Femhrt, Loestrin 21, Ovcon 35 21, Ovcon 50 28, Necon 0.5 35 21, Tri Norinyl 21 Day, Brevicon 21 Day, Ortho-Novum 7/7/7 28, Jenest-28, Necon 1 35 21, Norinyl 1 35 21 Day, Ortho Novum 1 Plus 35, Modicon, Nelova 10/11, Norethin 1/35E, Norethin 1/35, Nelova 1/35, Norlestrin, Brevicon, Nelova 0.5/35 E, Synphasic 21 day, Synphasic 28 day, Brevicon .5/35 21 day, Brevicon .5/35 28 day, Select 1/35 21 day, Brevicon 1/35 28 day, Select 1/35 28 day, Brevicon 1/35 21 day, Demulen, Ortho-Novum, Junel 1/20, Junel Fe 1/20, Junel 1.5/30, Loestrin 21 1/20, Microgestin 1/20, Microgestin 1.5/30, Ovcon-35, Ovcon-35 Chewable, Necon 0.5/35, Necon 1/35, Necon 10/11, Necon 7/7/7, Nortrel 0.5/35, Norinyl 1+35, Nortrel 1/35, Nortrel 7/7/7, Ortho-Novum 1/35, Ortho-Novum 10/11, Ortho-Novum 7/7/7, Ovcon-50, Gencept 10/11, Aranelle, Leena, Tri-Norinyl, Loestrin 20, Loestrin 21 1.5/30
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Ethinyl Estradiol, Norethindrone is classified as belonging to the following category: Estrogens
Androstenedione is a precursor to estrogen and seems to increase estrogen levels. There is some concern that taking androstenedione with estrogens might increase estrogenic effects and potential side effects. However, androstenedione is converted to estrogen only in low estrogen environments. Patients taking estrogen do not have low estrogen levels because of the estrogen treatment. Therefore, androstenedione is unlikely to be converted to estrogen in these patients. However, until more is known, use with caution or avoid using.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Broeder CE, Quindry J, Brittingham K, et al. The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000;160:30
- Leder BZ, Longcope C, Catlin DH, et al. Oral androstenedione administration and serum testosterone concentrations in young men. JAMA 2000;283:779-82.
- King DS, Sharp RL, Vukovich MD, et al. Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men. A randomized controlled trial. JAMA 1999;281:2020-8.
- Brown GA, Vukovich MD, Martini ER, et al. Endocrine responses to chronic androstenedione intake in 30- to 56-year-old men. J Clin Endocrinol Metab 2000;85:4074-80.
- Brown GA, Vukovich MD, Martini ER, et al. Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men. Int J Vitam Nutr Res 2001;71:293-301.
- Leder, B. Z., Leblanc, K. M., Longcope, C., Lee, H., Catlin, D. H., and Finkelstein, J. S. Effects of oral androstenedione administration on serum testosterone and estradiol levels in postmenopausal women. J Clin Endocrinol Metab 2002;87(12):5449-5454.
- Judge LW, Bellar DM, Hoover DL, Biggs D, Leitzelar BN, Craig BW. Effects of acute androstenedione supplementation on testosterone levels in older men. Aging Male. 2016;19(3):161-167.
Androstenedione Overview
Androstenedione is a naturally occurring prohormone produced in the body, primarily in the adrenal glands and gonads. It serves as a precursor to testosterone and estrogen. In the past, it was marketed as a dietary supplement with claims of enhancing athletic performance and increasing muscle mass. However, its effectiveness for these purposes is not well-supported by scientific evidence. Androstenedione gained attention in the late 1990s when it was linked to use by some athletes as a performance-enhancing substance, leading to its classification as a Schedule III controlled substance in the United States. It is also banned by organizations like the National Collegiate Athletic Association (NCAA) and the World Anti-Doping Agency (WADA) for use in sports competitions.
Androstenedione - More Interactions
Androstenedione interacts with 41 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
Return to the main herbal interaction checker page
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
Ask A Pharmacist About Your Herbal Questions!
Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
Ask A Pharmacist