Angelica Archangelica - Ruxolitinib Interaction
Herbal: Angelica Archangelica
Also Known As: American Angelica, Angelicae Fructus, Angelicae Herba, Angelicae Radix, Angel's Wort, Archangel, Bai Zhi, Canda, Dang Gui (Angelica root), Du Huo, European Angelica, Garden Angelica, Root of the Holy Ghost, Wild Angelica, Wild Parsnip
Drug: Ruxolitinib
Brand names:
Jakafi, Opzelura
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 02, 2024
Interaction Details
There were no interactions found between Ruxolitinib and Angelica Archangelica. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Angelica Archangelica Overview
Angelica archangelica, a perennial herb in the Apiaceae/Umbelliferae family, is characterized by its tall stature, typically reaching heights between 50-250 cm, and large, abundant leaves. Originating from the coastal regions of the North and Baltic Seas, this herb, also known as wild parsnip, has a notable history of use in culinary practices, traditional Chinese medicine, and as a flavoring agent in beverages and liqueurs. With its composition rich in essential oils, phytosterols, caffeic acid derivatives, and flavonoids, along with furanocoumarin compounds such as angelicin and imperatorin, Angelica archangelica is associated with various potential health benefits. These include antioxidant, anti-cancer, anti-fungal, anti-hypertensive, anxiolytic, and cognitive effects. Further research is required to fully elucidate its mechanisms of action and efficacy in treating different conditions. Angelica archangelica has Generally Recognized as Safe (GRAS) status in the United States.
Ruxolitinib Overview
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Ruxolitinib is used to treat myelofibrosis (a cancer of the bone marrow in which the bone marrow is replaced by scar tissue and causes decreased blood cell production). It is also used to treat polycythemia vera (PV; a slow growing cancer of the blood in which the bone marrow makes too many red blood cells) in people who were not able to be treated successfully with hydroxyurea. Ruxolitinib is also used to treat acute graft versus host disease (aGVHD; a complication of hematopoietic stem-cell transplant [HSCT; a procedure that replaces diseased bone marrow with healthy bone marrow] that usually develops within the first months after HSCT) in adults and children 12 years of age and older who were treated unsuccessfully with steroid medications. It is also used to treat chronic GVHD (cGVHD; a complication of HSCT that usually develops at least 3 months after HSCT) in adults and children 12 years of age and older who were treated unsuccessfully with 1 or 2 other treatments. Ruxolitinib is in a class of medications called kinase inhibitors. It works to treat myelofibrosis and PV by blocking the signals that cause cancer cells to multiply. This helps to stop the spread of cancer cells. It works to treat GVHD by blocking the signals of the cells that cause GVHD.
Angelica Archangelica - More Interactions
Angelica Archangelica interacts with 333 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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