Ashwagandha - Coreg (Carvedilol) Interaction

Interaction Details

Carvedilol is classified as belonging to the following category: Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Interaction Rating

Likelihood of Occurrence

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

Pharmacist Analysis

It is unlikely that ashwagandha has a significant risk of causing hypotension (low blood pressure) in most individuals. While clinical studies show that it may have a mild blood-pressure-lowering effect, no studies have reported significant side effects in this regard, or cases of hypotension.

Ashwagandha appears to have more appreciable clinical effects in regard to improving cardiorespiratory fitness and fatigue/recovery versus blood-pressure-lowering effects.

As always, however, be sure to let your doctor know of all the medications you are taking, including dietary supplements, so you can be appropriately monitored.

Ashwagandha With Coreg (Carvedilol) - Additional Details

While there is no direct evidence of a clinically significant interaction between Coreg and ashwagandha, Coreg is a medication that can lower blood pressure, so it would be prudent to be cautious combining it with ashwagandha, at least when first starting out, due to the potential of additive antihypertensive effects.

References

• Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.

Carvedilol Overview

• Carvedilol is used to treat heart failure (condition in which the heart cannot pump enough blood to all parts of the body) and high blood pressure. It also is used to treat people who have had a heart attack. Carvedilol is often used in combination with other medications. Carvedilol is in a class of medications called beta-blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure

• High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

Ashwagandha - More Interactions

Ashwagandha interacts with 1326 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.