Interaction Details

There were no interactions found between Botulinum Toxin Type A and Bacillus Coagulans. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.


Still looking for more information about combining Botulinum Toxin Type A and Bacillus Coagulans? Ask Dr. Brian Staiger about it by contacting him directly.

Bacillus Coagulans Overview

Bacillus Coagulans Bacillus coagulans, also known as Weizmannia coagulans or Lactobacillus sporogenes, is a spore-forming, lactic acid-producing, Gram-positive bacterium used as a probiotic. Bacillus coagulans has shown benefits for constipation and irritable bowel syndrome (IBS). Its spores are stable in stomach acid and reach the small intestine, where they germinate and multiply, with around 85% reaching their destination. The bacterium is excreted via feces, with spores detectable up to 7 days post-administration. Mechanistically, Bacillus coagulans exhibits antibacterial effects through the production of coagulin, lactic acid, and lactosporin, reducing pathogenic bacteria colonization. It also demonstrates antifungal properties and anti-inflammatory effects, potentially reducing the growth of pathogenic bacteria and decreasing the production of lipopolysaccharides. Bacillus coagulans may stimulate immune response, as evidenced by increased CD4+ T cells in adults with HIV-1 infection and modulation of inflammatory cytokines in schoolchildren. These properties categorize Bacillus coagulans as an immunomodulator, immunostimulant, and probiotic, with potential therapeutic applications in promoting digestive health and immune function.
See More Information Regarding Bacillus Coagulans

Botulinum Toxin Type A Overview

  • OnabotulinumtoxinA injection (Botox, Botox Cosmetic) is used to treat a number of conditions.

  • OnabotulinumtoxinA injection (Botox) is used to:

    • relieve the symptoms of cervical dystonia (spasmodic torticollis; uncontrollable tightening of the neck muscles that may cause neck pain and abnormal head positions) in people 16 years of age and older;

    • relieve the symptoms of strabismus (an eye muscle problem that causes the eye to turn inward or outward) and blepharospasm (uncontrollable tightening of the eyelid muscles that may cause blinking, squinting, and abnormal eyelid movements) in adults and adolescents 12 years of age and older;

    • prevent headaches in people older than 18 years of age with chronic migraine (severe, throbbing headaches that are sometimes accompanied by nausea and sensitivity to sound or light) who have 15 or more days each month with headaches lasting 4 hours a day or longer;

    • treat overactive bladder (a condition in which the bladder muscles contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination) in people 18 years of age and older when other medications do not work well enough or cannot be taken;

    • treat neurogenic detrusor overactivity (NDO; a bladder control condition caused by brain, spinal cord or nerve problem) in children 5 years of age and older when other medications did not help or could not be tolerated;

    • treat incontinence (leakage of urine) in people 18 years of age and older with overactive bladder (condition in which the bladder muscles have uncontrollable spasms) caused by nerve problems such as spinal cord injury or multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control), who cannot be treated with oral medication;

    • treat spasticity (muscle stiffness and tightness) of muscles in the arms and legs in adults and children 2 years of age and older;

    • treat severe underarm sweating in people 18 years of age and older who cannot be treated with products applied on the skin;

  • and

  • OnabotulinumtoxinA injection (Botox Cosmetic) is used to

    • temporarily smooth frown lines (wrinkles between the eyebrows) in adults 18 years of age and older,

    • temporarily smooth crow's feet lines (wrinkles near the outer corner of the eye) in adults 18 years of age and older,

    • and to temporarily smooth forehead lines in adults 18 years of age and older.

  • OnabotulinumtoxinA injection is in a class of medications called neurotoxins. When onabotulinumtoxinA is injected into a muscle, it blocks the nerve signals that cause uncontrollable tightening and movements of the muscle. When onabotulinumtoxinA is injected into a sweat gland, it decreases the activity of the gland to reduce sweating. When onabotulinumtoxinA is injected into the bladder, it decreases bladder contractions and blocks signals that tell the nervous system that the bladder is full.

See More Information Regarding OnabotulinumtoxinA Injection

Bacillus Coagulans - More Interactions

Bacillus Coagulans interacts with 179 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

Ask A Pharmacist About Your Herbal Questions!

Dr. Brian Staiger, PharmD

In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!

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