Bacillus Coagulans - Khapzory (Levoleucovorin) Interaction

Bacillus coagulans, also known as Weizmannia coagulans or Lactobacillus sporogenes, is a spore-forming, lactic acid-producing, Gram-positive bacterium used as a probiotic. Bacillus coagulans has shown benefits for constipation and irritable bowel syndrome (IBS). Its spores are stable in stomach acid and reach the small intestine, where they germinate and multiply, with around 85% reaching their destination. The bacterium is excreted via feces, with spores detectable up to 7 days post-administration. Mechanistically, Bacillus coagulans exhibits antibacterial effects through the production of coagulin, lactic acid, and lactosporin, reducing pathogenic bacteria colonization. It also demonstrates antifungal properties and anti-inflammatory effects, potentially reducing the growth of pathogenic bacteria and decreasing the production of lipopolysaccharides. Bacillus coagulans may stimulate immune response, as evidenced by increased CD4+ T cells in adults with HIV-1 infection and modulation of inflammatory cytokines in schoolchildren. These properties categorize Bacillus coagulans as an immunomodulator, immunostimulant, and probiotic, with potential therapeutic applications in promoting digestive health and immune function.