Bear's Garlic - Lipitor (Atorvastatin Calcium) Interaction
Herbal: Bear's Garlic
Also Known As: Allium ursinum, Ail des Bois, Ail à Feuilles Larges, Ail des Ours, Ail Pétiolé, Ajo de Oso, Ajo Silvestre, Baerlauch, Bear Garlic, Broad-leaved Garlic, Hog's Garlic, Ramsons, Wild Garlic, Wood Garlic
Drug: Atorvastatin Calcium
Brand names:
Lipitor
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 13, 2024
Interaction Details
There were no interactions found between Atorvastatin Calcium and Bear's Garlic. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Bear's Garlic Overview
Bear's garlic, also known as wild garlic or Allium ursinum, is a perennial plant native to Europe and parts of Asia. The herb and bulb of bear's garlic are commonly used in culinary applications, prized for their mild garlic flavor. Bear's garlic contains various beneficial compounds, including glucopyranoside, kaempferol, and flavonoids, although levels of alliin, a compound found in garlic, are lower in bear's garlic. It's important to note that many of these compounds are degraded if the plant is dried.
Research suggests that bear's garlic exhibits cardioprotective effects, with in vitro studies showing promising results. It moderately inhibits the angiotensin-converting enzyme (ACE), which could contribute to its purported cardioprotective and blood pressure-lowering effects. Additionally, bear's garlic leaf extract has been found to inhibit platelet aggregation in vitro, mainly through the inhibition of the ADP pathway. Specific non-sulphur constituents, such as 1,2-di-O-alpha-linolenoyl-3-O-beta-D-galactopyranosyl-sn-glycerol and beta-sitosterol-3-O-beta-D-glucoside, appear to be the most active antiplatelet constituents, along with some flavonoids.
Atorvastatin Calcium Overview
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Atorvastatin is used together with diet, weight loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Atorvastatin is also used to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol ('bad cholesterol') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol ('good cholesterol') in the blood. Atorvastatin may also be used to decrease the amount of cholesterol and other fatty substances in the blood in children and teenagers 10 to 17 years of age who have familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol cannot be removed from the body normally). Atorvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.
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Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats with atorvastatin has been shown to prevent heart disease, angina (chest pain), strokes, and heart attacks.
Bear's Garlic - More Interactions
Bear's Garlic interacts with 118 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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