Bear's Garlic - Lenvima (Lenvatinib) Interaction
Herbal: Bear's Garlic
Also Known As: Allium ursinum, Ail des Bois, Ail à Feuilles Larges, Ail des Ours, Ail Pétiolé, Ajo de Oso, Ajo Silvestre, Baerlauch, Bear Garlic, Broad-leaved Garlic, Hog's Garlic, Ramsons, Wild Garlic, Wood Garlic
Drug: Lenvatinib
Brand names:
Lenvima
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 02, 2024
Interaction Details
There were no interactions found between Lenvatinib and Bear's Garlic. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Bear's Garlic Overview
Bear's garlic, also known as wild garlic or Allium ursinum, is a perennial plant native to Europe and parts of Asia. The herb and bulb of bear's garlic are commonly used in culinary applications, prized for their mild garlic flavor. Bear's garlic contains various beneficial compounds, including glucopyranoside, kaempferol, and flavonoids, although levels of alliin, a compound found in garlic, are lower in bear's garlic. It's important to note that many of these compounds are degraded if the plant is dried.
Research suggests that bear's garlic exhibits cardioprotective effects, with in vitro studies showing promising results. It moderately inhibits the angiotensin-converting enzyme (ACE), which could contribute to its purported cardioprotective and blood pressure-lowering effects. Additionally, bear's garlic leaf extract has been found to inhibit platelet aggregation in vitro, mainly through the inhibition of the ADP pathway. Specific non-sulphur constituents, such as 1,2-di-O-alpha-linolenoyl-3-O-beta-D-galactopyranosyl-sn-glycerol and beta-sitosterol-3-O-beta-D-glucoside, appear to be the most active antiplatelet constituents, along with some flavonoids.
Lenvatinib Overview
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Lenvatinib is used to treat a certain type of thyroid cancer that has returned or that has spread to other parts of the body and cannot be treated with radioactive iodine. Lenvatinib is also used along with everolimus (Afinitor, Zortress) to treat renal cell carcinoma (RCC, a type of cancer that begins in the kidney) in people who have previously received treatment with another chemotherapy medication. Lenvatinib is also used along with pembrolizumab (Keytruda) as an initial treatment for advanced renal cell carcinoma. Lenvatinib is also used to treat hepatocellular carcinoma (HCC; a type of liver cancer) that cannot be treated with surgery. Lenvatinib is also used along with pembrolizumab (Keytruda) to treat a certain type of cancer of the endometrium (lining of the uterus) that has spread to other parts of the body or worsened during or after treatment with chemotherapy medications or that cannot be treated with surgery or radiation therapy. Lenvatinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.
Bear's Garlic - More Interactions
Bear's Garlic interacts with 120 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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