Boxwood - Imodium (Loperamide) Interaction
Herbal: Boxwood
Also Known As: Buxus sempervirens, Bois d'Artois, Bois Béni, Bois Ordinaire, Boj, Boje, Boxwood Extract, Buis, Buis Commun, Buis Toujours Vert, Bujo, Bush Tree, Buxaceae, Buxus, Dudgeon, European Box, Extrait de Buis, SPV 30
Drug: Loperamide
Brand names:
Imodium, Loperamide
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 02, 2024
Interaction Details
Loperamide is classified as belonging to the following category: Anticholinergic Drugs
Evidence from in vitro research suggests that boxwood extract can inhibit acetylcholinesterase activity. Theoretically, concurrent use of anticholinergic drugs and boxwood might decrease the effectiveness of boxwood or the anticholinergic agent.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Orhan, I., Sener, B., Choudhary, M. I., and Khalid, A. Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants. J Ethnopharmacol 2004;91(1):57-60.
Boxwood Overview
Boxwood is a type of shrub that is commonly used in landscaping and gardening. It belongs to the Buxus genus, which includes about 70 species of evergreen plants. The leaves of boxwood have been used in traditional medicine to treat malaria, and to boost immunity. Boxwood has also been used to treat arthritis and diabetes. Boxwood supplements are generally processed extracts since the whole leaf of the plant is toxic to humans and animals.
Loperamide Overview
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Nonprescription (over-the-counter) loperamide is used to control acute diarrhea (loose stools that come on suddenly and usually lasts less than 2 weeks), including travelers' diarrhea. Prescription loperamide is also used to control acute diarrhea and also ongoing diarrhea associated with inflammatory bowel disease (IBD; condition in which the lining of all or part of the intestine is swollen, irritated, or has sores). Prescription loperamide is also used to reduce the amount of fluid in people with ileostomies (surgery to create an opening for waste to leave the body through the abdomen). Loperamide is in a class of medications called antidiarrheal agents. It works by decreasing the flow of fluids and electrolytes into the bowel and by slowing down the movement of the bowel to decrease the number of bowel movements.
Boxwood - More Interactions
Boxwood interacts with 216 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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