Canadian Fleabane - Imbruvica (Ibrutinib) Interaction

Interaction Details

Ibrutinib is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs

Theoretically, Canadian fleabane might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs. Canadian fleabane has been shown to inhibit platelet aggregation in vitro.
Some anticoagulant/antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Interaction Rating

Likelihood of Occurrence

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

• Saluk-Juszczak J, Olas B, Pawlaczyk I, Gancarz R, Wachowicz B. Effects of the extract from Conyza canadensis on human blood platelet aggregation. Gen Physiol Biophys 2007;26(2):150-2.
• Olas B, Saluk-Juszczak J, Pawlaczyk I, et al. Antioxidant and antiaggregatory effects of an extract from Conyza canadensis on blood platelets in vitro. Platelets 2006;17(6):354-60.

Ibrutinib Overview

• Ibrutinib is used:

  • to treat people with mantle cell lymphoma (MCL; a fast-growing cancer that begins in the cells of the immune system) who have already been treated with at least one other chemotherapy medication,

  • to treat people with chronic lymphocytic leukemia (CLL; a type of cancer that begins in the white blood cells) and small lymphocytic lymphoma (SLL; a type of cancer that begins mostly in the lymph nodes),

  • to treat people with Waldenstrom's macroglobulinemia (WM; a slow-growing cancer that begins in certain white blood cells in your bone marrow),

  • to treat people with marginal zone lymphoma (MZL; a slow growing cancer that begins in a type of white blood cells that normally fights infection) who have already been treated with a certain type of chemotherapy medication,

  • and to treat people with chronic graft vs host disease (cGVHD; a complication of hematopoietic stem-cell transplant [HSCT; a procedure that replaces diseased bone marrow with healthy bone marrow] that may start a while after the transplant and last for a long time) after being treated unsuccessfully with 1 or more medications.

• Ibrutinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.

Canadian Fleabane - More Interactions

Canadian Fleabane interacts with 118 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.