Cassava - Aldactone (Spironolactone) Interaction
Herbal: Cassava
Also Known As: Manihot esculenta, Brazilian Arrowroot, Cassave, Kassava, Kassave, Mandioca, Manioc, Manioc Tapioca, Manioca, Maniok, Maniokki, Tapioca, Tapioca Plant, Yuca
Drug: Spironolactone
Brand names:
Aldactone, Spiroton, Carospir
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 13, 2024
Interaction Details
There were no interactions found between Spironolactone and Cassava. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Cassava Overview
Cassava, also known as yuca, is a starchy root vegetable and a dietary mainstay in numerous tropical and developing nations. Despite its nutritional significance, cassava is not without concern, as it contains potentially harmful cyanogenic glycosides. Ongoing research is directed towards the development of genetically modified variants with reduced toxicity, aiming to mitigate health-related concers associated with its consumption.
In addition to its role as a dietary staple, cassava supplements are sometimes marketed as a fertility aid, specifically highlighting an increased probability of conceiving twins. This claim is grounded in the notion that select cassava supplements can induce hyper-ovulation without the adverse effects commonly associated with prescription fertility medications. It is pertinent to note, however, that this assertion currently lacks any substantiation in studies.
Beyond its purported use for fertility, available evidence suggests a potential reduction in the risk of developing type 2 diabetes with an increased intake of cassava flour in the diet.
Spironolactone Overview
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Spironolactone is used to treat certain patients with hyperaldosteronism (the body produces too much aldosterone, a naturally occurring hormone); low potassium levels; heart failure; and in patients with edema (fluid retention) caused by various conditions, including liver, or kidney disease. It is also used alone or with other medications to treat high blood pressure. Spironolactone is in a class of medications called aldosterone receptor antagonists. It causes the kidneys to eliminate unneeded water and sodium from the body into the urine but reduces the loss of potassium from the body.
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High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.
Cassava - More Interactions
Cassava interacts with 16 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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