Migranal Generic Name Question

In our latest question and answer, our pharmacist provides some clarity on the nasal spray Migranal.


What is the generic name of Migranal? Thanks!

Asked by Ali On Apr 26, 2024

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Apr 26, 2024
Last updated May 19, 2024


Hello and thank you for reaching out!

Regarding your question about Migranal, it seems you made a typo by spelling it 'Migrinol'. 'I'll assume you meant 'Migranal.' Please let me know if you are referring to a different drug.

Migranal is a brand name for dihydroergotamine mesylate 4mg/mL nasal spray. This medication falls under the category of ergotamine derivatives and is commonly used to treat acute migraines and cluster headaches.

According to research, intranasal dihydroergotamine mesylate has been shown to be highly effective in treating migraines. In fact, one study reported that more than 70% of individuals experiencing a headache found relief within 4 hours of administration.

However, it's important to note that dihydroergotamine mesylate nasal spray has certain limitations to it being more widely used. For instance, it cannot be used in combination with some common migraine medications (such as 'Triptans'), it must be used very cautiously in those with cardiovascular issues and it has serious interactions with various other drugs.

For more detailed information about this medication, you can see more on a different section of our website.

Migranal is available generically. Additionally, a different 'branded' version of nasal dihydroergotamine is available as Trudhesa. This product targets the upper nasal cavity with a delivery system that could enhance the systemic availability of dihydroergotamine, potentially making it more effective.

Final Words

I hope you find this information helpful!


  • Acute treatment of migraine with dihydroergotamine nasal spray. Dihydroergotamine Working Group, PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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