Conjugated Linoleic Acid (cla) - Aleve (Naproxen) Interaction

Herbal: Conjugated Linoleic Acid (cla)

Drug: Naproxen
Brand names: Naprosyn, Naprelan, Anaprox, Anaprox DS, Naproxyn, Navalbine, Naproxen, Naprosyn EC, Napro-Na, Aleve, Arthroxen, Synflex, EC-Naprosyn

Medical Content Editor
Last updated Jul 22, 2023

Interaction Details

Naproxen is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs

Theoretically, CLA may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Some clinical evidence suggests that intake of CLA reduces platelet aggregation by approximately 10%. The clinical significance of this effect is unclear.

Interaction Rating

Moderate

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

  • Sofi, F., Buccioni, A., Cesari, F., Gori, A. M., Minieri, S., Mannini, L., Casini, A., Gensini, G. F., Abbate, R., and Antongiovanni, M. Effects of a dairy product (pecorino cheese) naturally rich in cis-9, trans-11 conjugated linoleic acid on lipid, inf

Conjugated Linoleic Acid (cla) Overview

Conjugated Linoleic Acid (cla) Conjugated linoleic acid (CLA) is a type of polyunsaturated fatty acid found in small amounts in the meat and dairy products of certain animals. It is also found in small amounts in some plant-based oils, such as safflower and sunflower oil. The majority of dietary supplements utilize CLA obtained from safflower oil. CLA has been the subject of numerous scientific studies and has been suggested to have a number of potential health benefits, including weight loss, improving body composition, reducing inflammation, and decreasing the risk of certain types of cancer. However, the evidence for these potential benefits is mixed and more research is needed to fully understand the effects of CLA on health.
See More Information Regarding Conjugated Linoleic Acid (cla)

Naproxen Overview

  • Prescription naproxen is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), juvenile arthritis (a form of joint disease in children), and ankylosing spondylitis (arthritis that mainly affects the spine). Prescription naproxen tablets, extended-release tablets, and suspension are also used to relieve shoulder pain caused by bursitis (inflammation of a fluid-filled sac in the shoulder joint), tendinitis (inflammation of the tissue that connects muscle to bone), gouty arthritis (attacks of joint pain caused by a build-up of certain substances in the joints), and pain from other causes, including menstrual pain (pain that happens before or during a menstrual period). Nonprescription naproxen is used to reduce fever and to relieve mild pain from headaches, muscle aches, arthritis, menstrual periods, the common cold, toothaches, and backaches. Naproxen is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

See More Information Regarding Naproxen

Conjugated Linoleic Acid (cla) - More Interactions

Conjugated Linoleic Acid (cla) interacts with 283 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

Visit Our Drug-Herbal Interaction Checker

Drug-Herbal Interaction Checker

Check your medications for potential interactions with herbal supplements

Popular Interaction Pages

Copper - Naltrexone
Oleic Acid - Acetylsalicylic Acid
Hedge Mustard - Epoetin Beta
Humic Acid - Bortezomib
Lactobacillus Jensenii - Metformin, Linagliptin
Niacin - Enfortumab Vedotin-ejfv
Burdock - Hydrocodone, Ibuprofen
Cnidium - Polycarbophil
Poppy Seed - Deferiprone
Jimson Weed - Indacaterol
Ground Ivy - Oxazepam
Shirodhara - Pegfilgrastim-apgf
Alpha-gpc - Denosumab
Field Scabious - Immune Globulin, Gamma Globulin
Devil's Club - Medroxyprogesterone Acetate, Oestrogens, Conjugated
Bayberry - Azithromycin
Melanotan - Darunavir
Toothed Clubmoss - Chlorpheniramine, Phenylpropanolamine
Chervil - Rubella/mumps Virus Live
Trypsin - Teriparatide

Return to the main herbal interaction checker page

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

Dr. Brian Staiger, PharmD

Ask A Pharmacist About Your Herbal Questions!

Dr. Brian Staiger, PharmD

In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!

Ask A Pharmacist