Corn Silk - Hydroflumethiazide Interaction
Herbal: Corn Silk
Also Known As: Zea mays, Barbe de Maïs, Blé d'Inde, Cheveux de Maïs, Corn Silk Tea, Indian Corn, Maidis Stigma, Maïs Violet, Maize Silk, Maydis Stigma, Purple Corn, Seda de Maíz, Soie de Maïs, Stigma Maydis, Yu Mi Xiu, Zea
Drug: Hydroflumethiazide
Brand names:
Saluron
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Hydroflumethiazide is classified as belonging to the following category: Antihypertensive Drugs
In clinical research, corn silk extract reduced systolic and diastolic blood pressure in both hypertensive and non-hypertensive individuals. Taking corn silk extract with antihypertensive drugs might increase the risk for hypotension.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- George GO, Idu FK. Corn silk aqueous extracts and intraocular pressure of systemic and non-systemic hypertensive subjects. Clin Exp Optom. 2015 Mar;98(2):138-49.
Interaction Details
Hydroflumethiazide is classified as belonging to the following category: Diuretic Drugs
Overuse of corn silk might compound diuretic-induced potassium loss. In human research, corn silk extract increases the volume of urine and increases the excretion of sodium and potassium. There is some concern that people taking corn silk along with potassium depleting diuretics might have an increased risk for hypokalemia. Initiation of potassium supplementation or an increase in potassium supplement dose may be necessary for some patients. Some diuretics that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydrodiuril, Microzide), and others.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- George GO, Idu FK. Corn silk aqueous extracts and intraocular pressure of systemic and non-systemic hypertensive subjects. Clin Exp Optom. 2015 Mar;98(2):138-49.
Corn Silk Overview
Corn silk is the thin, hair-like strands that grow from the ear of a corn plant. It is found inside the husk of the ear, along with the corn kernels. Corn silk is used in traditional medicine for its purported diuretic, anti-inflammatory, and soothing properties as it contains a number of compounds, including flavonoids, proteins, carbohydrates, vitamins, minerals, fiber, volatile oils, sitosterol, stigmasterol, alkaloids, tannins, and saponins. It is used for a variety of conditions, including treat bladder and kidney problems, urinary tract infections, and prostate issues.
Corn Silk - More Interactions
Corn Silk interacts with 284 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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