Delta-9-tetrahydrocannabinol (thc) - Pifeltro (Doravirine) Interaction
Herbal: Delta-9-tetrahydrocannabinol (thc)
Also Known As: BHO, Black Glass, Budder, Butane Hash Oil, Butane Honey Oil, Butter, Dabs, Delta-9 Tetrahydrocannabinol, Delta-9 THC, Delta-9-THC, Dronabinol, Honeycomb
Drug: Doravirine
Brand names:
Pifeltro
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Doravirine is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, THC may increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that cannabis containing THC can inhibit the activity of CYP3A4 enzymes, which might decrease the metabolism of CYP3A4 substrates. It is unclear if this effect is due to THC, other constituents, or the combination.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Pellinen, P., Honkakoski, P., Stenback, F., Niemitz, M., Alhava, E., Pelkonen, O., Lang, M. A., and Pasanen, M. Cocaine N-demethylation and the metabolism-related hepatotoxicity can be prevented by cytochrome P450 3A inhibitors. Eur.J Pharmacol 1-3-1994;2
Delta-9-tetrahydrocannabinol (thc) Overview
Delta-9-tetrahydrocannabinol (THC), also known as tetrahydrocannabinol, is a cannabinoid. It is one of the over 80 constituents, known as cannabinoids, that have been identified from Cannabis sativa. THC is the major psychoactive compound of cannabis and is most often associated with the plant's recreational use. THC is known to produce a range of effects on the body and mind, including relaxation, altered senses, and changes in mood and cognition. THC has also been used to treat pain and anxiety symptoms.
Doravirine Overview
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Doravirine is used along with other medications to treat human immunodeficiency virus (HIV) infection in adults who have not been treated with other HIV medications. It is also used to replace current medication therapy in certain people already taking HIV medications. Doravirine is in a class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). It works by decreasing the amount of HIV in the blood. Although doravirine does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other lifestyle changes may decrease the risk of transmitting (spreading) the HIV virus to other people.
Delta-9-tetrahydrocannabinol (thc) - More Interactions
Delta-9-tetrahydrocannabinol (thc) interacts with 1054 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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