Docosahexaenoic Acid (dha) - Propranolol Hydrochloride Interaction
Herbal: Docosahexaenoic Acid (dha)
Also Known As: ADH, DHA, Fish Oil Fatty Acid, N-3 Fatty Acid, Neuromins, Omega 3, Omega 3 Fatty Acids, Omega-3, Omega-3 Fatty Acids, W-3 Fatty Acid
Drug: Propranolol Hydrochloride
Brand names:
Hemangeol
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Propranolol Hydrochloride is classified as belonging to the following category: Antihypertensive Drugs
Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.
Fish oils containing DHA can lower blood pressure and might have additive effects in patients treated with antihypertensives; use with caution.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- Prisco D, Paniccia R, Bandinelli B, et al. Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. Thromb Res 1998;1:105-12.
- Toft I, Bonaa KH, Ingebretsen OC, et al. Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension. A randomized, controlled trial. Ann Intern Med 1995;123:911-8.
- Sacks FM, Hebert P, Appel LJ, et al. Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the trials of hypertension prevention. J Hypertens 1994;12:209-13.
- Vandongen R, Mori TA, Burke V, et al. Effects on blood pressure of omega 3 fats in subjects at increased risk of cardiovascular disease. Hypertension 1993;22:371-9.
- Mori, T. A., Bao, D. Q., Burke, V., Puddey, I. B., and Beilin, L. J. Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. Hypertension 1999;34(2):253-260.
- Nestel, P., Shige, H., Pomeroy, S., Cehun, M., Abbey, M., and Raederstorff, D. The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. Am.J.Clin.Nutr. 2002;76(2):326-330.
- Woodman, R. J., Mori, T. A., Burke, V., Puddey, I. B., Barden, A., Watts, G. F., and Beilin, L. J. Effects of purified eicosapentaenoic acid and docosahexaenoic acid on platelet, fibrinolytic and vascular function in hypertensive type 2 diabetic patients
- Theobald, H. E., Goodall, A. H., Sattar, N., Talbot, D. C., Chowienczyk, P. J., and Sanders, T. A. Low-dose docosahexaenoic acid lowers diastolic blood pressure in middle-aged men and women. J Nutr 2007;137(4):973-978.
Docosahexaenoic Acid (dha) Overview
DHA (docosahexaenoic acid) is an omega-3 fatty acid that is important for the proper functioning of the nervous system and eyes.
DHA can be found in a variety of foods and in abundance in many different types of fatty fish, such as salmon and mackerel. It is a popular dietary supplement, consistently among the most utilized.
There is some evidence to suggest that DHA may have a number of potential health benefits, including improving cognitive function and reducing the risk of age-related cognitive decline. It has also been shown to be important for fetal and infant brain development and is a common component in prenatal vitamins.
DHA is often combined with EPA (eicosapentaenoic acid) in dietary supplements and both are found together in most fish-sourced ones. One main difference between DHA and EPA is their structure. DHA is a long-chain fatty acid, while EPA is a medium-chain fatty acid. This difference in structure may affect how they are utilized in the body and their potential health benefits. For example, DHA is more highly concentrated in the brain and is believed to be important for brain and eye health, while EPA is more highly concentrated in the heart and may be helpful in reducing inflammation and improving cardiovascular health.
Propranolol Hydrochloride Overview
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Propranolol oral solution is used to treat proliferating infantile hemangioma (benign [noncancerous] growths or tumors appearing on or under the skin shortly after birth) in infants 5 weeks to 5 months of age. Propranolol is in a class of medications called beta blockers. It works by narrowing the blood vessels already formed and by preventing new ones from growing.
Docosahexaenoic Acid (dha) - More Interactions
Docosahexaenoic Acid (dha) interacts with 367 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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