Eastern Red Cedar - Pentobarbital Interaction Details

Interaction Details

Pentobarbital is classified as belonging to the following category: Barbiturates

In mice and rats given hexobarbital or pentobarbital, sleep time is reduced and metabolism of the drug is increased when they inhale essential oil vapor from Eastern red cedar wood chips in their bedding. Cedrol and cedrene in the essential oil are reported to induce liver microsomal enzymes. Theoretically, inhaling Eastern red cedar wood fragrance might reduce the efficacy of hexobarbital or pentobarbital in humans.

Interaction Rating

Minor

Likelihood of Occurrence

Unlikely

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

References

Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Johnson W. Final report on the safety assessment of Juniperus communis Extract, Juniperus oxycedrus Extract, Juniperus oxycedrus Tar, Juniperus phoenicea extract, and Juniperus virginiana Extract. Int J Toxicol 2001;20 Suppl 2:41-56.

Eastern Red Cedar - More Interactions

Eastern Red Cedar interacts with 49 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major	The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate	Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor	Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown	No interactions have been reported or no interaction data is currently available.