Echinacea - Tylenol (Acetaminophen) Interaction
Herbal: Echinacea
Also Known As: American Cone Flower, Black Sampson, Black Susans, Comb Flower, Coneflower, Echinaceawurzel, Hedgehog, Igelkopfwurzel, Indian Head, Kansas Snakeroot
Drug: Acetaminophen
Brand names:
Tylenol Ex Strength, Children's Tylenol, Tylenol, Children's Tylenol Meltaways
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Acetaminophen is classified as belonging to the following category: Cytochrome P450 1A2 (Cyp1A2) Substrates
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Echinacea appears to inhibit CYP1A2 enzymes in humans. Additionally, echinacea seems to increase plasma concentrations of caffeine, a CYP1A2 substrate, by around 30%. Theoretically, echinacea might increase levels of other drugs metabolized by CYP1A2.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Pharmacist Analysis
While echinacea may inhibit Cytochrome P450 1A2 to some degree, it has not been reported as being responsible for causing adverse effects when combined with Tylenol when used at recommended dosages, likely due to the fact that Tylenol has multiple metabolic pathways (e.g., glucuronidation and sulfate conjugation in addition to CYP1A2).
For most individuals, Tylenol should be safe to combine with echinacea on an intermittent basis.
- Dr. Brian Staiger, PharmDReferences
- Gorski JC, Huang S, Zaheer NA, et al. The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo.Clin Pharmacol Ther 2003;73 (Abstract PDII-A-8):P94.
Echinacea Overview
Echinacea is a type of flowering plant that belongs to the daisy family and is native to cental and eastern North America. It is known for its purple, cone-shaped flowers. In traditional medicine, echinacea has been used to treat a variety of conditions, including colds, flu, and other respiratory infections. It is believed to work by stimulating the immune system and helping the body to fight off infection. Some studies have suggested that echinacea may be effective at reducing the severity and duration of colds and other respiratory infections, but more research is needed to confirm its effectiveness.
Acetaminophen Overview
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Acetaminophen is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. Acetaminophen may also be used to relieve the pain of osteoarthritis (arthritis caused by the breakdown of the lining of the joints). Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body.
Echinacea - More Interactions
Echinacea interacts with 768 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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