Fenugreek - Amylase, Lipase, Protease Interaction
Herbal: Fenugreek
Also Known As: Trigonella foenum-graecum, Alholva, Bird's Foot, Chandrika, Fenogreco, Fenugrec, Foenugreek, Greek Clover, Greek Hay, Hu Lu Ba, Methi, Methika, Medhika, Senegrain, Senegre, Trigonella, Trigonelle
Drug: Amylase, Lipase, Protease
Brand names:
Pangestyme MT 16, Pangestyme CN 10, Pangestyme CN 20, Pangestyme EC, Pangestyme UL 12, Pangestyme UL 18, Pangestyme UL 20, Pancrelipase, Pancrelipase 10,000, Lipram 10,000, Pancrecarb Ms-4, Ku-Zyme, Kutrase, Digepepsin, Pancrecarb Ms-8, Pancrelipase 16,000, Pancrelipase 20,000, Pancron 20, Festal II, Microspheres, Zymase, Entozyme, Ku-Zyme HP, Protilase, Ilozyme, Plaretase, Ultresa
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 13, 2024
Interaction Details
There were no interactions found between Amylase, Lipase, Protease and Fenugreek. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Pharmacist Analysis
Fenugreek is generally considered relatively safe in regard to potential drug interactions.
Nevertheless, interactions are possible between fenugreek and:
- 'Blood-thinning' drugs
- Drugs that lower blood pressure
- Drugs that low blood sugar
Fenugreek contains some components that can prevent blood from clotting. However, there is not enough research to confirm whether the amount of these components present in common fenugreek products can have a clinically significant effect.
Fenugreek may also have an additive effect with blood sugar-lowering medication and blood pressure-lowering medication.
All of these potential interactions are documented individually on our specific drug-herbal interaction pages.
- Dr. Brian Staiger, PharmDFenugreek Overview
Fenugreek (Trigonella foenum-graecum) is a plant native to the Mediterranean region and western Asia. The seeds have a nutty, slightly bitter taste and are commonly used in different types of cuisine. The leaves, which are known as "methi," are used in cooking as well.
In addition to its use as a spice and herb, fenugreek has a long history of use in traditional medicine. Some studies have suggested that fenugreek may have potential health benefits, including the ability to lower blood sugar levels in people with diabetes, improve cholesterol levels, and reduce inflammation. It may also have potential benefits for women who are breastfeeding, as it is thought to increase milk production and improve the quality of breast milk.
Amylase, Lipase, Protease Overview
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Pancrelipase delayed-release capsules (Creon, Pancreaze, Pertzye, Ultresa, Zenpep) are used to improve digestion of food in children and adults who do not have enough pancreatic enzymes (substances needed to break down food so it can be digested) because they have a condition that affects the pancreas (a gland that produces several important substances including enzymes needed to digest food) such as cystic fibrosis (an inborn disease that causes the body to produce thick, sticky mucus that may clog the pancreas, the lungs, and other parts of the body), chronic pancreatitis (swelling of the pancreas that does not go away), or a blockage in the passages between the pancreas and the intestine. Pancrelipase delayed-release capsules (Creon, Pancreaze, Zenpep) are also used to improve digestion of food in infants who do not have enough pancreatic enzymes (substances needed to break down food so it can be digested) because they have cystic fibrosis or another condition that affects the pancreas. Pancrelipase delayed-release capsules (Creon) are also used to improve digestion in people who have had surgery to remove all or part of the pancreas or stomach. Pancrelipase tablets (Viokace) are used along with another medication (proton pump inhibitor; PPI) to improve digestion of foods in adults who have chronic pancreatitis or who have had surgery to remove the pancreas. Pancrelipase is in a class of medications called enzymes. Pancrelipase acts in place of the enzymes normally made by the pancreas. It works to decrease fatty bowel movements and to improve nutrition by breaking down fats, proteins, and starches from food into smaller substances that can be absorbed from the intestine.
Fenugreek - More Interactions
Fenugreek interacts with 374 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
Ask A Pharmacist About Your Herbal Questions!
Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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