Interaction Details

Trimethadione is classified as belonging to the following category: Cns Depressants

Theoretically, taking Galphimia glauca with CNS depressants may increase the risk of sedation.
Galphimia glauca extract seems to have sedative effects.

Interaction Rating


Likelihood of Occurrence


Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists


  • Herrera-Arellano, A., Jimenez-Ferrer, E., Zamilpa, A., et al. Efficacy and tolerability of a standardized herbal product from Galphimia glauca on generalized anxiety disorder. A randomized, double-blind clinical trial controlled with lorazepam. Planta Med
  • Herrera-Arellano A, Jiménez-Ferrer JE, Zamilpa A, García-Alonso G, Herrera-Alvarez S, Tortoriello J. Therapeutic effectiveness of Galphimia glauca vs. lorazepam in generalized anxiety disorder. A controlled 15-week clinical trial. Planta Med. 2012;78(14):

Galphimia Glauca Overview

Galphimia Glauca Galphimia glauca is an evergreen shrub belonging to the Malpighiaceae family and is most commonly known as thryallis. It is native to the subtropical regions of the Americas, including Mexico. Galphimia glauca leaves have been used in traditional medicine for the treatment of insomnia, anxiety and respiratory problems. It has also been used as an anticonvulsant.
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Trimethadione Overview

  • Trimethadione is used to control absence seizures (petit mal; a type of seizure in which there is a very short loss of awareness during which the person may stare straight ahead or blink his eyes and does not respond to others) when other medications will not work. Trimethadione is in a class of medications called anticonvulsants. It works by reducing abnormal electrical activity in the brain.

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Galphimia Glauca - More Interactions

Galphimia Glauca interacts with 247 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!

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