Green Coffee - Letairis (Ambrisentan) Interaction
Herbal: Green Coffee
Also Known As: Coffea arabica, Coffea canephora, Coffea bukobensis, Arabica Green Coffee Beans, Raw Coffee
Drug: Ambrisentan
Brand names:
Letairis, Volibris
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Ambrisentan is classified as belonging to the following category: Antihypertensive Drugs
Theoretically, taking green coffee with antihypertensive drugs might increase the risk of hypotension.
Clinical studies have shown that green coffee extract decreases blood pressure. When used with antihypertensive drugs, green coffee might have additive blood pressure-lowering effects. However, this has not been shown in clinical research.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Kozuma K, Tsuchiya S, Kohori J, et al. Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects. Hypertens Res. 2005 Sep;28(9):711-8.
- Watanabe T, Arai Y, Mitsui Y, et al. The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clin Exp Hypertens 2006;28:439-49.
Green Coffee Overview
Green coffee refers to coffee beans that have not been roasted (unlike regular coffee, which is roasted). They are typically a pale green color and have a mild, slightly bitter flavor.
One of the main differences between green coffee and regular coffee is the amount of chlorogenic acid they contain. Chlorogenic acid is a plant compound that is found in high levels in green coffee beans, but it is largely destroyed during the roasting process. As a result, green coffee has a higher concentration of chlorogenic acid than regular coffee.
Green coffee is often consumed as a supplement in the form of capsules, tablets, or powders, and is purported to have a number of potential health benefits. Some research suggests that green coffee may help with weight loss, lower blood pressure, and improve blood sugar control, but more data is needed for more definitive conclusions.
Ambrisentan Overview
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Ambrisentan is used alone or in combination with tadalafil (Adcirca, Cialis) to treat pulmonary arterial hypertension (PAH, high blood pressure in the vessels that carry blood to the lungs). Ambrisentan may improve the ability to exercise and slow the worsening of symptoms in people with PAH. Ambrisentan is in a class of medications called endothelin receptor antagonists. It works by stopping the action of endothelin, a natural substance that causes blood vessels to narrow and prevents normal blood flow in people who have PAH.
Green Coffee - More Interactions
Green Coffee interacts with 662 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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