Griffonia Simplicifolia - Amphetamine Interaction

Interaction Details

Amphetamine is classified as belonging to the following category: Monoamine Oxidase Inhibitors (Maois)

Combining serotonergic drugs such as a nonselective monoamine oxidase inhibitor (MAOI) with 5-HTP, a constituent of Griffonia simplicifolia seed extract, might increase the risk of serotonergic side effects including serotonin syndrome and cerebral vasoconstrictive disorders such as Call-Fleming syndrome. A case report describes a 60 year old man who was stable on phenelzine 75 mg daily, pramipexole, zolpidem, quetiapine, and intermittent prednisone. He started taking 5-HTP 300 mg daily with immediate improvement in depressive symptoms. However, within 2 weeks he developed manic symptoms and hyperreflexia. Although he stopped treatment with 5-HTP, symptoms did not improve until he was hospitalized 12 days later and treated with increasing doses of quetiapine. It is not clear if taking Griffonia simplicifolia in combination with MAOIs might have the same effects. MAOIs include isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate).

Interaction Rating

Likelihood of Occurrence

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

• Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3.
• Pardo JV. Mania following addition of hydroxytryptophan to monoamine oxidase inhibitor. Gen Hosp Psychiatry 2012;34(1):102.e13-4.

Amphetamine Overview

• Amphetamine (Adzenys ER, Adzenys XR, Dyanavel XR, Evekeo, Evekeo ODT, others) is used as part of a treatment program to control symptoms of attention deficit hyperactivity disorder (ADHD; more difficulty focusing, controlling actions, and remaining still or quiet than other people who are the same age) in adults and children. Amphetamine (Evekeo, others) is also used to treat narcolepsy (a sleep disorder that causes excessive daytime sleepiness and sudden attacks of sleep). Amphetamine (Evekeo, others) is also used for a limited period of time (a few weeks) along with a reduced calorie diet and an exercise plan for weight loss in obese people unable to lose weight. Amphetamine is in a class of medications called central nervous system stimulants. It works by changing the amounts of certain natural substances in the brain.

Griffonia Simplicifolia - More Interactions

Griffonia Simplicifolia interacts with 315 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.